Heterogeneous distribution of Plasmodium falciparum drug resistance haplotypes in subsets of the host population
Abstract Background The emergence of drug resistance is a major problem in malaria control. For mathematical modelling of the transmission and spread of drug resistance the determinant parameters need to be identified and measured. The underlying hypothesis is that mutations associated with drug res...
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ftdoajarticles:oai:doaj.org/article:9a8d0cb5020e4c95978f4d1bc825933e 2023-05-15T15:07:39+02:00 Heterogeneous distribution of Plasmodium falciparum drug resistance haplotypes in subsets of the host population Mueller Ivo Baisor Moses Goroti Mary Marfurt Jutta Schoepflin Sonja Felger Ingrid 2008-05-01T00:00:00Z https://doi.org/10.1186/1475-2875-7-78 https://doaj.org/article/9a8d0cb5020e4c95978f4d1bc825933e EN eng BMC http://www.malariajournal.com/content/7/1/78 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-7-78 1475-2875 https://doaj.org/article/9a8d0cb5020e4c95978f4d1bc825933e Malaria Journal, Vol 7, Iss 1, p 78 (2008) Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2008 ftdoajarticles https://doi.org/10.1186/1475-2875-7-78 2022-12-31T09:13:29Z Abstract Background The emergence of drug resistance is a major problem in malaria control. For mathematical modelling of the transmission and spread of drug resistance the determinant parameters need to be identified and measured. The underlying hypothesis is that mutations associated with drug resistance incur fitness costs to the parasite in absence of drug pressure. The distribution of drug resistance haplotypes in different subsets of the host population was investigated. In particular newly acquired haplotypes after radical cure were characterized and compared to haplotypes from persistent infections. Methods Mutations associated with antimalarial drug resistance were analysed in parasites from children, adults, and new infections occurring after treatment. Twenty-five known single nucleotide polymorphisms from four Plasmodium falciparum genes associated with drug resistance were genotyped by DNA chip technology. Results Haplotypes were found to differ between subsets of the host population. A seven-fold mutated haplotype was significantly reduced in adults compared to children and new infections, whereas parasites harbouring fewer mutations were more frequent in adults. Conclusion The reduced frequency of highly mutated parasites in chronic infections in adults is likely a result of fitness costs of drug resistance that increases with number of mutations and is responsible for reduced survival of mutant parasites. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 7 1 78 |
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Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Mueller Ivo Baisor Moses Goroti Mary Marfurt Jutta Schoepflin Sonja Felger Ingrid Heterogeneous distribution of Plasmodium falciparum drug resistance haplotypes in subsets of the host population |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background The emergence of drug resistance is a major problem in malaria control. For mathematical modelling of the transmission and spread of drug resistance the determinant parameters need to be identified and measured. The underlying hypothesis is that mutations associated with drug resistance incur fitness costs to the parasite in absence of drug pressure. The distribution of drug resistance haplotypes in different subsets of the host population was investigated. In particular newly acquired haplotypes after radical cure were characterized and compared to haplotypes from persistent infections. Methods Mutations associated with antimalarial drug resistance were analysed in parasites from children, adults, and new infections occurring after treatment. Twenty-five known single nucleotide polymorphisms from four Plasmodium falciparum genes associated with drug resistance were genotyped by DNA chip technology. Results Haplotypes were found to differ between subsets of the host population. A seven-fold mutated haplotype was significantly reduced in adults compared to children and new infections, whereas parasites harbouring fewer mutations were more frequent in adults. Conclusion The reduced frequency of highly mutated parasites in chronic infections in adults is likely a result of fitness costs of drug resistance that increases with number of mutations and is responsible for reduced survival of mutant parasites. |
format |
Article in Journal/Newspaper |
author |
Mueller Ivo Baisor Moses Goroti Mary Marfurt Jutta Schoepflin Sonja Felger Ingrid |
author_facet |
Mueller Ivo Baisor Moses Goroti Mary Marfurt Jutta Schoepflin Sonja Felger Ingrid |
author_sort |
Mueller Ivo |
title |
Heterogeneous distribution of Plasmodium falciparum drug resistance haplotypes in subsets of the host population |
title_short |
Heterogeneous distribution of Plasmodium falciparum drug resistance haplotypes in subsets of the host population |
title_full |
Heterogeneous distribution of Plasmodium falciparum drug resistance haplotypes in subsets of the host population |
title_fullStr |
Heterogeneous distribution of Plasmodium falciparum drug resistance haplotypes in subsets of the host population |
title_full_unstemmed |
Heterogeneous distribution of Plasmodium falciparum drug resistance haplotypes in subsets of the host population |
title_sort |
heterogeneous distribution of plasmodium falciparum drug resistance haplotypes in subsets of the host population |
publisher |
BMC |
publishDate |
2008 |
url |
https://doi.org/10.1186/1475-2875-7-78 https://doaj.org/article/9a8d0cb5020e4c95978f4d1bc825933e |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 7, Iss 1, p 78 (2008) |
op_relation |
http://www.malariajournal.com/content/7/1/78 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-7-78 1475-2875 https://doaj.org/article/9a8d0cb5020e4c95978f4d1bc825933e |
op_doi |
https://doi.org/10.1186/1475-2875-7-78 |
container_title |
Malaria Journal |
container_volume |
7 |
container_issue |
1 |
container_start_page |
78 |
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1766339113625059328 |