Could vaccinating adults against malaria materially reduce adult mortality in high-transmission areas?
Abstract After a period of unprecedented progress against malaria in the 2000s, halving the global disease burden by 2015, gains overall in sub-Saharan Africa have slowed and even reversed in some places, beginning well before the COVID-19 pandemic. The highly effective drugs, treated nets, and diag...
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ftdoajarticles:oai:doaj.org/article:9a7db689be4744949791564db0c27cc5 2023-10-29T02:34:30+01:00 Could vaccinating adults against malaria materially reduce adult mortality in high-transmission areas? Hellen Gelband Ronald Carshon-Marsh Rashid Ansumana Ibrahim Bob Swaray Arjun Pandey Ashley Aimone Isaac Bogoch John Eikelboom Prabhat Jha 2023-09-01T00:00:00Z https://doi.org/10.1186/s12936-023-04714-z https://doaj.org/article/9a7db689be4744949791564db0c27cc5 EN eng BMC https://doi.org/10.1186/s12936-023-04714-z https://doaj.org/toc/1475-2875 doi:10.1186/s12936-023-04714-z 1475-2875 https://doaj.org/article/9a7db689be4744949791564db0c27cc5 Malaria Journal, Vol 22, Iss 1, Pp 1-5 (2023) Malaria Adult mortality Vaccines Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2023 ftdoajarticles https://doi.org/10.1186/s12936-023-04714-z 2023-10-01T00:42:13Z Abstract After a period of unprecedented progress against malaria in the 2000s, halving the global disease burden by 2015, gains overall in sub-Saharan Africa have slowed and even reversed in some places, beginning well before the COVID-19 pandemic. The highly effective drugs, treated nets, and diagnostics that fueled the initial progress all face some threats to their effectiveness, and global funding to maintain and increase their use over the long term is not guaranteed. Malaria vaccines are among the most promising new interventions that could accelerate the elimination of malaria. Vaccines are still in early stages of rollout in children, the age group (along with pregnant women) that has been the focus of malaria strategies for a century. At the same time, over the past decade, a case has been made, based largely on evidence from verbal autopsies in at least a few high-transmission areas, that the malaria death rate among adults has been greatly underestimated. Could vaccinating adults help to bring down the adult malaria mortality rate, contribute to reduced transmission, or both? A randomized trial of a malaria vaccine is proposed in Sierra Leone, a highly endemic setting, to shed light on this proposition. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Malaria Journal 22 1 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
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Malaria Adult mortality Vaccines Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Malaria Adult mortality Vaccines Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Hellen Gelband Ronald Carshon-Marsh Rashid Ansumana Ibrahim Bob Swaray Arjun Pandey Ashley Aimone Isaac Bogoch John Eikelboom Prabhat Jha Could vaccinating adults against malaria materially reduce adult mortality in high-transmission areas? |
topic_facet |
Malaria Adult mortality Vaccines Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract After a period of unprecedented progress against malaria in the 2000s, halving the global disease burden by 2015, gains overall in sub-Saharan Africa have slowed and even reversed in some places, beginning well before the COVID-19 pandemic. The highly effective drugs, treated nets, and diagnostics that fueled the initial progress all face some threats to their effectiveness, and global funding to maintain and increase their use over the long term is not guaranteed. Malaria vaccines are among the most promising new interventions that could accelerate the elimination of malaria. Vaccines are still in early stages of rollout in children, the age group (along with pregnant women) that has been the focus of malaria strategies for a century. At the same time, over the past decade, a case has been made, based largely on evidence from verbal autopsies in at least a few high-transmission areas, that the malaria death rate among adults has been greatly underestimated. Could vaccinating adults help to bring down the adult malaria mortality rate, contribute to reduced transmission, or both? A randomized trial of a malaria vaccine is proposed in Sierra Leone, a highly endemic setting, to shed light on this proposition. |
format |
Article in Journal/Newspaper |
author |
Hellen Gelband Ronald Carshon-Marsh Rashid Ansumana Ibrahim Bob Swaray Arjun Pandey Ashley Aimone Isaac Bogoch John Eikelboom Prabhat Jha |
author_facet |
Hellen Gelband Ronald Carshon-Marsh Rashid Ansumana Ibrahim Bob Swaray Arjun Pandey Ashley Aimone Isaac Bogoch John Eikelboom Prabhat Jha |
author_sort |
Hellen Gelband |
title |
Could vaccinating adults against malaria materially reduce adult mortality in high-transmission areas? |
title_short |
Could vaccinating adults against malaria materially reduce adult mortality in high-transmission areas? |
title_full |
Could vaccinating adults against malaria materially reduce adult mortality in high-transmission areas? |
title_fullStr |
Could vaccinating adults against malaria materially reduce adult mortality in high-transmission areas? |
title_full_unstemmed |
Could vaccinating adults against malaria materially reduce adult mortality in high-transmission areas? |
title_sort |
could vaccinating adults against malaria materially reduce adult mortality in high-transmission areas? |
publisher |
BMC |
publishDate |
2023 |
url |
https://doi.org/10.1186/s12936-023-04714-z https://doaj.org/article/9a7db689be4744949791564db0c27cc5 |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 22, Iss 1, Pp 1-5 (2023) |
op_relation |
https://doi.org/10.1186/s12936-023-04714-z https://doaj.org/toc/1475-2875 doi:10.1186/s12936-023-04714-z 1475-2875 https://doaj.org/article/9a7db689be4744949791564db0c27cc5 |
op_doi |
https://doi.org/10.1186/s12936-023-04714-z |
container_title |
Malaria Journal |
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22 |
container_issue |
1 |
_version_ |
1781057130488397824 |