Effect of dietary intervention on the prevalence of asymptomatic malaria among 6–18-month-old children in rural Malawi
Abstract Background The complex interaction between malaria and undernutrition leads to increased mortality and morbidity rate among young children in malaria-endemic regions. Results from previous interventions suggest that improving nutritional status of young children may reduce the burden of mal...
Published in: | Malaria Journal |
---|---|
Main Authors: | , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
BMC
2023
|
Subjects: | |
Online Access: | https://doi.org/10.1186/s12936-023-04701-4 https://doaj.org/article/9a434148c4b540219eeba8a2e82422d9 |
id |
ftdoajarticles:oai:doaj.org/article:9a434148c4b540219eeba8a2e82422d9 |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:9a434148c4b540219eeba8a2e82422d9 2023-10-09T21:49:34+02:00 Effect of dietary intervention on the prevalence of asymptomatic malaria among 6–18-month-old children in rural Malawi Hany Sady David Chaima Lotta Hallamaa Emma Kortekangas Ulla Ashorn Jomo Banda Charles Mangani Kenneth Maleta Per Ashorn Yue-Mei Fan 2023-09-01T00:00:00Z https://doi.org/10.1186/s12936-023-04701-4 https://doaj.org/article/9a434148c4b540219eeba8a2e82422d9 EN eng BMC https://doi.org/10.1186/s12936-023-04701-4 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-023-04701-4 1475-2875 https://doaj.org/article/9a434148c4b540219eeba8a2e82422d9 Malaria Journal, Vol 22, Iss 1, Pp 1-9 (2023) Asymptomatic malaria Children Dietary Intervention Malawi Prevalence rate Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2023 ftdoajarticles https://doi.org/10.1186/s12936-023-04701-4 2023-09-24T00:42:55Z Abstract Background The complex interaction between malaria and undernutrition leads to increased mortality and morbidity rate among young children in malaria-endemic regions. Results from previous interventions suggest that improving nutritional status of young children may reduce the burden of malaria. This study tested a hypothesis that provision of lipid-based nutrient supplements (LNS) or corn-soy blend (CSB) supplementation to 6–18-month-old children in Malawi would reduce the prevalence of asymptomatic malaria among them. Methods A total of 840 6-month-old children were enrolled in a randomized trial. The participants received 12-month supplementation with three different daily dietary supplementations: CSB, soy-LNS, or milk-LNS, and one control group without supplementation. The prevalence rate of asymptomatic Plasmodium falciparum was determined by real-time PCR from the participant’s dried blood spots (DBS) collected at the baseline and every 3 months. The global null hypothesis was tested using modified Poisson regression to estimate the prevalence ratio (PR) between the control group and three intervention groups at all ages combined. All the models were adjusted for malaria at baseline, season of DBS sample collection, site of enrolment, and household asset Z-score. Results All children combined, the prevalence of P. falciparum was 14.1% at enrollment, 8.7% at 9 months, 11.2% at 12 months, 13.0% at 15 months and 22.4% at 18 months of age. Among all samples that were taken after enrolment, the prevalence was 12.1% in control group, 12.2% in milk-LNS, 14.0% in soy-LNS, and 17.2% in CSB group. Compared to children in the control group the prevalence ratio of positive malaria tests was 1.19 (95% CI 0.81–1.74; P = 0.372) in the milk-LNS group, 1.32 (95% CI 0.88–1.96; P = 0.177) in the soy-LNS group and 1.72 (95% CI 1.19–2.49; P = 0.004) in the CSB group. Conclusion The study findings do not support a hypothesis that LNS or CSB supplementation would reduce the prevalence of asymptomatic malaria among ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 22 1 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Asymptomatic malaria Children Dietary Intervention Malawi Prevalence rate Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Asymptomatic malaria Children Dietary Intervention Malawi Prevalence rate Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Hany Sady David Chaima Lotta Hallamaa Emma Kortekangas Ulla Ashorn Jomo Banda Charles Mangani Kenneth Maleta Per Ashorn Yue-Mei Fan Effect of dietary intervention on the prevalence of asymptomatic malaria among 6–18-month-old children in rural Malawi |
topic_facet |
Asymptomatic malaria Children Dietary Intervention Malawi Prevalence rate Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background The complex interaction between malaria and undernutrition leads to increased mortality and morbidity rate among young children in malaria-endemic regions. Results from previous interventions suggest that improving nutritional status of young children may reduce the burden of malaria. This study tested a hypothesis that provision of lipid-based nutrient supplements (LNS) or corn-soy blend (CSB) supplementation to 6–18-month-old children in Malawi would reduce the prevalence of asymptomatic malaria among them. Methods A total of 840 6-month-old children were enrolled in a randomized trial. The participants received 12-month supplementation with three different daily dietary supplementations: CSB, soy-LNS, or milk-LNS, and one control group without supplementation. The prevalence rate of asymptomatic Plasmodium falciparum was determined by real-time PCR from the participant’s dried blood spots (DBS) collected at the baseline and every 3 months. The global null hypothesis was tested using modified Poisson regression to estimate the prevalence ratio (PR) between the control group and three intervention groups at all ages combined. All the models were adjusted for malaria at baseline, season of DBS sample collection, site of enrolment, and household asset Z-score. Results All children combined, the prevalence of P. falciparum was 14.1% at enrollment, 8.7% at 9 months, 11.2% at 12 months, 13.0% at 15 months and 22.4% at 18 months of age. Among all samples that were taken after enrolment, the prevalence was 12.1% in control group, 12.2% in milk-LNS, 14.0% in soy-LNS, and 17.2% in CSB group. Compared to children in the control group the prevalence ratio of positive malaria tests was 1.19 (95% CI 0.81–1.74; P = 0.372) in the milk-LNS group, 1.32 (95% CI 0.88–1.96; P = 0.177) in the soy-LNS group and 1.72 (95% CI 1.19–2.49; P = 0.004) in the CSB group. Conclusion The study findings do not support a hypothesis that LNS or CSB supplementation would reduce the prevalence of asymptomatic malaria among ... |
format |
Article in Journal/Newspaper |
author |
Hany Sady David Chaima Lotta Hallamaa Emma Kortekangas Ulla Ashorn Jomo Banda Charles Mangani Kenneth Maleta Per Ashorn Yue-Mei Fan |
author_facet |
Hany Sady David Chaima Lotta Hallamaa Emma Kortekangas Ulla Ashorn Jomo Banda Charles Mangani Kenneth Maleta Per Ashorn Yue-Mei Fan |
author_sort |
Hany Sady |
title |
Effect of dietary intervention on the prevalence of asymptomatic malaria among 6–18-month-old children in rural Malawi |
title_short |
Effect of dietary intervention on the prevalence of asymptomatic malaria among 6–18-month-old children in rural Malawi |
title_full |
Effect of dietary intervention on the prevalence of asymptomatic malaria among 6–18-month-old children in rural Malawi |
title_fullStr |
Effect of dietary intervention on the prevalence of asymptomatic malaria among 6–18-month-old children in rural Malawi |
title_full_unstemmed |
Effect of dietary intervention on the prevalence of asymptomatic malaria among 6–18-month-old children in rural Malawi |
title_sort |
effect of dietary intervention on the prevalence of asymptomatic malaria among 6–18-month-old children in rural malawi |
publisher |
BMC |
publishDate |
2023 |
url |
https://doi.org/10.1186/s12936-023-04701-4 https://doaj.org/article/9a434148c4b540219eeba8a2e82422d9 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 22, Iss 1, Pp 1-9 (2023) |
op_relation |
https://doi.org/10.1186/s12936-023-04701-4 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-023-04701-4 1475-2875 https://doaj.org/article/9a434148c4b540219eeba8a2e82422d9 |
op_doi |
https://doi.org/10.1186/s12936-023-04701-4 |
container_title |
Malaria Journal |
container_volume |
22 |
container_issue |
1 |
_version_ |
1779312593914036224 |