Estudo imunológico da esquistossomose mansoni intestinal antes e após tratamento com aminonitrotiazol

• Main Authors: Lucyr Jones Antunes, Dirceu Wagner Carvalho de Souza, Maria Suzana de Lemos Souza, Regina Maria de Marco Turchetti, João Paulo Mendes de Oliveira, Roberto Pedercini Marinho, Ana Zélia Almendra Correia Lima
• Format: Article in Journal/Newspaper
• Language: English
• Published: Sociedade Brasileira de Medicina Tropical (SBMT) 1974
• Subjects: Arctic medicine. Tropical medicine; RC955-962; Arctic; Elevado
• Online Access: https://doaj.org/article/9a11ecc3fe10442f8b20e18a088ff9d7

Foram dosadas as imunoglobulinas e realizados testes cutâneos para se avaliar o sistema imunológico de pacientes portadores da forma intestinal da esquistossomose mansoni. Estes testes foram realizados antes do tratamento com aminonitrotiazol e após trinta, sessenta e noventa dias do tratamento. Antes do tratamento o nível de IgG (1893 ± 472 mg%) apresentava-se elevado, mas os níveis de IgA (186 ± 74 mg%) e de IgM (91 ± 26 mg%) achavam-se normais. Decorridos trinta, sessenta e noventa dias do tratamento, o nível de IgG diminuiu, observando-se ligeira elevação de IgA bem como de IgM. Os pacientes, antes do tratamento, quando testados com schistosomina e anti IgE apresentaram áreas de 1,22 ± 0,36 cm² e 1,04 ± 0,25 cm², respectivamente. Noventa dias após o tratamento, as reações à schistosomina e ao soro anti IgE produziram reações com áreas ainda maiores. Os testes de hipersensibilidade retardada mostraram que 35% dos pacientes reagiram à schistosomina e 71% ao 2-4 dinitrofluorobenzeno. The amount of immunoglobulins serum and the cutaneous sensitivity to specific antigen in 19 patients with intestinal schistosomiasis were determined, as an attempt to study the incidence of delayed and imediate type of hypersensitivity. The tests were performed before and thirty, sixty and ninety days after treatment with aminonitrotiazol. The immunoglobulin levels before treatment were found to be 1,893 ± 472, 186 ± 74 and 91 ± 26 mg%, respectively for IgG, IgA and IgM; ninety days after treatment the level for IgG became normal (1,266 ± 389 mg%) and a slight increase of IgA (270 ± 89 mg%) and IgM (111 ± 31 mg%) was observed. The patients were intradermally tested with schistosomin and with anti IgE serum. The tests before treatment gave the following resulta: 1.22 ± 0.36 cm² for schistosomin and 1.04 ± 0.25 cm² for anti IgE. Ninety days afterwards a slight increase of the reactions was observed and the results respectively were 1.42 ± 0.65 cm² and 1.15 ± 0.32 cm². The studies for delayed hypersenstivity indicated that 35% of ...