Usnea aurantiaco-atra (Jacq) Bory: Metabolites and Biological Activities
Background: Lichens are complex symbiotic associations between a fungus and an alga or cyanobacterium. Due to their great adaptability to the environment, they have managed to colonize many terrestrial habitats, presenting a worldwide distribution from the poles to the tropical regions and from the...
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2023
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Online Access: | https://doi.org/10.3390/molecules28217317 https://doaj.org/article/999fa452497a4ff5835807967af1facd |
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ftdoajarticles:oai:doaj.org/article:999fa452497a4ff5835807967af1facd 2023-12-10T09:42:12+01:00 Usnea aurantiaco-atra (Jacq) Bory: Metabolites and Biological Activities María Jesús Vega-Bello Mari Luz Moreno Rossana Estellés-Leal José Miguel Hernández-Andreu Jesús A. Prieto-Ruiz 2023-10-01T00:00:00Z https://doi.org/10.3390/molecules28217317 https://doaj.org/article/999fa452497a4ff5835807967af1facd EN eng MDPI AG https://www.mdpi.com/1420-3049/28/21/7317 https://doaj.org/toc/1420-3049 doi:10.3390/molecules28217317 1420-3049 https://doaj.org/article/999fa452497a4ff5835807967af1facd Molecules, Vol 28, Iss 21, p 7317 (2023) antioxidant activity cytotoxicity phenolic metabolites Usnea aurantiaco-atra usnic acid Organic chemistry QD241-441 article 2023 ftdoajarticles https://doi.org/10.3390/molecules28217317 2023-11-12T01:36:05Z Background: Lichens are complex symbiotic associations between a fungus and an alga or cyanobacterium. Due to their great adaptability to the environment, they have managed to colonize many terrestrial habitats, presenting a worldwide distribution from the poles to the tropical regions and from the plains to the highest mountains. In the flora of the Antarctic region, lichens stand out due to their variety and development and are a potential source of new bioactive compounds. Methods: A phytochemical study of the Antarctic lichen Usnea aurantiaco-atra (Jacq) Bory was conducted with the intention of determining the most important metabolites. In addition, the cytotoxic and antioxidant activities of its extracts were determined. Results: Cytotoxicity studies revealed that the hexane extract contains usnic acid as a majority metabolite, in addition to linoleic acid, ergosterols and terpenes, and demonstrates cytotoxic activity against an A375 melanoma cell line. On the other hand, the presence of total phenols in the extracts did not influence their antioxidant activity. Conclusions: U. aurantiaco-atra contains mainly usnic acid, although there are terpenes and ergosta compounds that could be responsible for its cytotoxic activity. The presence of phenols did not confer antioxidant properties. Article in Journal/Newspaper Antarc* Antarctic Directory of Open Access Journals: DOAJ Articles Antarctic Bory ENVELOPE(40.372,40.372,64.489,64.489) The Antarctic Molecules 28 21 7317 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
antioxidant activity cytotoxicity phenolic metabolites Usnea aurantiaco-atra usnic acid Organic chemistry QD241-441 |
spellingShingle |
antioxidant activity cytotoxicity phenolic metabolites Usnea aurantiaco-atra usnic acid Organic chemistry QD241-441 María Jesús Vega-Bello Mari Luz Moreno Rossana Estellés-Leal José Miguel Hernández-Andreu Jesús A. Prieto-Ruiz Usnea aurantiaco-atra (Jacq) Bory: Metabolites and Biological Activities |
topic_facet |
antioxidant activity cytotoxicity phenolic metabolites Usnea aurantiaco-atra usnic acid Organic chemistry QD241-441 |
description |
Background: Lichens are complex symbiotic associations between a fungus and an alga or cyanobacterium. Due to their great adaptability to the environment, they have managed to colonize many terrestrial habitats, presenting a worldwide distribution from the poles to the tropical regions and from the plains to the highest mountains. In the flora of the Antarctic region, lichens stand out due to their variety and development and are a potential source of new bioactive compounds. Methods: A phytochemical study of the Antarctic lichen Usnea aurantiaco-atra (Jacq) Bory was conducted with the intention of determining the most important metabolites. In addition, the cytotoxic and antioxidant activities of its extracts were determined. Results: Cytotoxicity studies revealed that the hexane extract contains usnic acid as a majority metabolite, in addition to linoleic acid, ergosterols and terpenes, and demonstrates cytotoxic activity against an A375 melanoma cell line. On the other hand, the presence of total phenols in the extracts did not influence their antioxidant activity. Conclusions: U. aurantiaco-atra contains mainly usnic acid, although there are terpenes and ergosta compounds that could be responsible for its cytotoxic activity. The presence of phenols did not confer antioxidant properties. |
format |
Article in Journal/Newspaper |
author |
María Jesús Vega-Bello Mari Luz Moreno Rossana Estellés-Leal José Miguel Hernández-Andreu Jesús A. Prieto-Ruiz |
author_facet |
María Jesús Vega-Bello Mari Luz Moreno Rossana Estellés-Leal José Miguel Hernández-Andreu Jesús A. Prieto-Ruiz |
author_sort |
María Jesús Vega-Bello |
title |
Usnea aurantiaco-atra (Jacq) Bory: Metabolites and Biological Activities |
title_short |
Usnea aurantiaco-atra (Jacq) Bory: Metabolites and Biological Activities |
title_full |
Usnea aurantiaco-atra (Jacq) Bory: Metabolites and Biological Activities |
title_fullStr |
Usnea aurantiaco-atra (Jacq) Bory: Metabolites and Biological Activities |
title_full_unstemmed |
Usnea aurantiaco-atra (Jacq) Bory: Metabolites and Biological Activities |
title_sort |
usnea aurantiaco-atra (jacq) bory: metabolites and biological activities |
publisher |
MDPI AG |
publishDate |
2023 |
url |
https://doi.org/10.3390/molecules28217317 https://doaj.org/article/999fa452497a4ff5835807967af1facd |
long_lat |
ENVELOPE(40.372,40.372,64.489,64.489) |
geographic |
Antarctic Bory The Antarctic |
geographic_facet |
Antarctic Bory The Antarctic |
genre |
Antarc* Antarctic |
genre_facet |
Antarc* Antarctic |
op_source |
Molecules, Vol 28, Iss 21, p 7317 (2023) |
op_relation |
https://www.mdpi.com/1420-3049/28/21/7317 https://doaj.org/toc/1420-3049 doi:10.3390/molecules28217317 1420-3049 https://doaj.org/article/999fa452497a4ff5835807967af1facd |
op_doi |
https://doi.org/10.3390/molecules28217317 |
container_title |
Molecules |
container_volume |
28 |
container_issue |
21 |
container_start_page |
7317 |
_version_ |
1784884967216513024 |