The Baikal subtype of tick-borne encephalitis virus is evident of recombination between Siberian and Far-Eastern subtypes.
Tick-borne encephalitis virus (TBEV) is a flavivirus which causes an acute or sometimes chronic infection that frequently has severe neurological consequences, and is a major public health threat in Eurasia. TBEV is genetically classified into three distinct subtypes; however, at least one group of...
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ftdoajarticles:oai:doaj.org/article:999a1a2fbe844d45b16f685ee1bb842c 2023-06-06T11:51:13+02:00 The Baikal subtype of tick-borne encephalitis virus is evident of recombination between Siberian and Far-Eastern subtypes. Grigorii A Sukhorukov Alexey I Paramonov Oksana V Lisak Irina V Kozlova Georgii A Bazykin Alexey D Neverov Lyudmila S Karan 2023-03-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0011141 https://doaj.org/article/999a1a2fbe844d45b16f685ee1bb842c EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0011141 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0011141 https://doaj.org/article/999a1a2fbe844d45b16f685ee1bb842c PLoS Neglected Tropical Diseases, Vol 17, Iss 3, p e0011141 (2023) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2023 ftdoajarticles https://doi.org/10.1371/journal.pntd.0011141 2023-04-16T00:34:13Z Tick-borne encephalitis virus (TBEV) is a flavivirus which causes an acute or sometimes chronic infection that frequently has severe neurological consequences, and is a major public health threat in Eurasia. TBEV is genetically classified into three distinct subtypes; however, at least one group of isolates, the Baikal subtype, also referred to as "886-84-like", challenges this classification. Baikal TBEV is a persistent group which has been repeatedly isolated from ticks and small mammals in the Buryat Republic, Irkutsk and Trans-Baikal regions of Russia for several decades. One case of meningoencephalitis with a lethal outcome caused by this subtype has been described in Mongolia in 2010. While recombination is frequent in Flaviviridae, its role in the evolution of TBEV has not been established. Here, we isolate and sequence four novel Baikal TBEV samples obtained in Eastern Siberia. Using a set of methods for inference of recombination events, including a newly developed phylogenetic method allowing for formal statistical testing for such events in the past, we find robust support for a difference in phylogenetic histories between genomic regions, indicating recombination at origin of the Baikal TBEV. This finding extends our understanding of the role of recombination in the evolution of this human pathogen. Article in Journal/Newspaper Arctic Siberia Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 17 3 e0011141 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Grigorii A Sukhorukov Alexey I Paramonov Oksana V Lisak Irina V Kozlova Georgii A Bazykin Alexey D Neverov Lyudmila S Karan The Baikal subtype of tick-borne encephalitis virus is evident of recombination between Siberian and Far-Eastern subtypes. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Tick-borne encephalitis virus (TBEV) is a flavivirus which causes an acute or sometimes chronic infection that frequently has severe neurological consequences, and is a major public health threat in Eurasia. TBEV is genetically classified into three distinct subtypes; however, at least one group of isolates, the Baikal subtype, also referred to as "886-84-like", challenges this classification. Baikal TBEV is a persistent group which has been repeatedly isolated from ticks and small mammals in the Buryat Republic, Irkutsk and Trans-Baikal regions of Russia for several decades. One case of meningoencephalitis with a lethal outcome caused by this subtype has been described in Mongolia in 2010. While recombination is frequent in Flaviviridae, its role in the evolution of TBEV has not been established. Here, we isolate and sequence four novel Baikal TBEV samples obtained in Eastern Siberia. Using a set of methods for inference of recombination events, including a newly developed phylogenetic method allowing for formal statistical testing for such events in the past, we find robust support for a difference in phylogenetic histories between genomic regions, indicating recombination at origin of the Baikal TBEV. This finding extends our understanding of the role of recombination in the evolution of this human pathogen. |
format |
Article in Journal/Newspaper |
author |
Grigorii A Sukhorukov Alexey I Paramonov Oksana V Lisak Irina V Kozlova Georgii A Bazykin Alexey D Neverov Lyudmila S Karan |
author_facet |
Grigorii A Sukhorukov Alexey I Paramonov Oksana V Lisak Irina V Kozlova Georgii A Bazykin Alexey D Neverov Lyudmila S Karan |
author_sort |
Grigorii A Sukhorukov |
title |
The Baikal subtype of tick-borne encephalitis virus is evident of recombination between Siberian and Far-Eastern subtypes. |
title_short |
The Baikal subtype of tick-borne encephalitis virus is evident of recombination between Siberian and Far-Eastern subtypes. |
title_full |
The Baikal subtype of tick-borne encephalitis virus is evident of recombination between Siberian and Far-Eastern subtypes. |
title_fullStr |
The Baikal subtype of tick-borne encephalitis virus is evident of recombination between Siberian and Far-Eastern subtypes. |
title_full_unstemmed |
The Baikal subtype of tick-borne encephalitis virus is evident of recombination between Siberian and Far-Eastern subtypes. |
title_sort |
baikal subtype of tick-borne encephalitis virus is evident of recombination between siberian and far-eastern subtypes. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2023 |
url |
https://doi.org/10.1371/journal.pntd.0011141 https://doaj.org/article/999a1a2fbe844d45b16f685ee1bb842c |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic Siberia |
genre_facet |
Arctic Siberia |
op_source |
PLoS Neglected Tropical Diseases, Vol 17, Iss 3, p e0011141 (2023) |
op_relation |
https://doi.org/10.1371/journal.pntd.0011141 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0011141 https://doaj.org/article/999a1a2fbe844d45b16f685ee1bb842c |
op_doi |
https://doi.org/10.1371/journal.pntd.0011141 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
17 |
container_issue |
3 |
container_start_page |
e0011141 |
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1767956933559451648 |