Antibody response in cattle after vaccination with inactivated and attenuated rabies vaccines

• Main Authors: Andréa de Cássia RODRIGUES da SILVA, Graciane Maria Medeiros CAPORALE, Celso Alberto GONÇALVES, Mosar Couteiro TARGUETA, Fabiano COMIN, Carlos Roberto ZANETTI, Ivanete KOTAIT
• Format: Article in Journal/Newspaper
• Language: English
• Published: Universidade de São Paulo (USP) 2000
• Subjects: Rabies; Cattle vaccination; Neutralizing antibodies; Antirabies IgG; Arctic medicine. Tropical medicine; RC955-962; Infectious and parasitic diseases; RC109-216; Arctic
• Online Access: https://doaj.org/article/996bf28119974fa5b0d3d55f1ce045ef

Despite the absence of current official reports showing the number of cattle infected by rabies, it is estimated that nearly 30,000 bovines are lost each year in Brazil. In order to minimize the important economic losses, control of the disease is achieved by eliminating bat colonies and by herd vaccination. In this study, we compare the antibody response in cattle elicited by vaccination with an attenuated ERA vaccine (AEvac) and an inactivated-adjuvanted PV (IPVvac) vaccine. The antibody titers were appraised by cell-culture neutralization test and ELISA, and the percentage of seropositivity was ascertained for a period of 180 days. IPVvac elicited complete seropositivity rates from day 30 to day 150, and even on day 180, 87% of the sera showed virus-neutralizing antibody titers (VNA) higher than 0.5IU/ml. There were no significant differences between the VNA titers and seropositivity rates obtained with IPVvac in the two methods tested. AEvac, however, elicited significantly lower titers than those observed in the group receiving inactivated vaccine. In addition, the profiles of antirabies IgG antibodies, evaluated by ELISA, and VNA, appraised by cell-culture neutralization test, were slightly different, when both vaccines were compared.