Study of 30 cases of histoplasmosis observed in the Mato Grosso do Sul State, Brazil Estudo de 30 casos de histoplasmose no Estado de Mato Grosso do Sul, Brasil

• Published in: Revista do Instituto de Medicina Tropical de São Paulo
• Main Authors: Marilene Rodrigues Chang, Cleison Ledesma Taira, Anamaria Melo Miranda Paniago, Deborah Ledesma Taira, Rivaldo Venâncio Cunha, Bodo Wanke
• Format: Article in Journal/Newspaper
• Language: English
• Published: Universidade de São Paulo (USP) 2007
• Subjects: Histoplasmosis; Histoplasma capsulatum; AIDS; Mato Grosso do Sul; Arctic medicine. Tropical medicine; RC955-962; Infectious and parasitic diseases; RC109-216; Arctic
• Online Access: https://doi.org/10.1590/S0036-46652007000100007; https://doaj.org/article/991f583e86b642e09decdb8be49b57a9

Thirty cases of histoplasmosis observed at the University Hospital of the Federal University of Mato Grosso do Sul (HU-UFMS) from January 1998 to December 2005 are reported. Most (83.3%) of the patients were men, average 33.4 years old, 63.3% of them were born and living in Mato Grosso do Sul and 83.3% presented AIDS as an underlying disease. In almost all cases (96.7%) the disease occurred in its disseminated form and the most frequent clinical manifestations were: fever (83.3%), weight loss (70.0%), cough (63.3%), hepatomegaly and splenomegaly (40.0%), and lymph node enlargement (36.7%). The laboratory diagnosis was obtained in 29 patients by isolation of Histoplasma capsulatum from various clinical specimens cultivated in Sabouraud dextrose and brain heart infusion agar and in 16 patients the fungus was observed by direct microscopy of Giemsa-stained smears. The observed mortality was 40%. This is the first report in the literature of the occurrence of histoplasmosis in Mato Grosso do Sul State. Foram estudados 30 casos de histoplasmose observados no estado de Mato Grosso do Sul - HU-UFMS, no período de janeiro de 1998 a dezembro de 2005. Os pacientes eram, na maioria, homens (83,3%) jovens (média de 33,4 anos de idade), naturais e procedentes de Mato Grosso do Sul (63,3%) e tinham AIDS como principal doença subjacente (83,3%). Houve predomínio da forma disseminada (96,7%) e as manifestações clínicas mais freqüentes foram: febre (83,3%), emagrecimento (70,0%) tosse (63,3%), hepatoesplenomegalia (40,0%) e linfonodomegalia (36,7%). O diagnóstico laboratorial foi obtido por exame microscópio direto de esfregaços corados pela técnica de Giemsa, em 16 pacientes, e isolamento de H. capsulatum em cultivo nos meios de agar Sabouraud dextrose e agar infusão de cérebro e coração, de materiais diversos, em 29 pacientes. A letalidade observada foi de 40%. O trabalho apresenta, pela primeira vez na literatura, a ocorrência de histoplasmose-doença no Estado de Mato Grosso do Sul.