A case control study of the relationship between persistent serum creatine kinase elevation and polyneuropathy
Abstract Creatine kinase (CK) has been associated with neuropathy, but the mechanisms are uncertain. We hypothesized that peripheral nerve function is impaired in subjects with persistent CK elevation (hyperCKemia) compared to age- and sex matched controls in a general population. The participants w...
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ftdoajarticles:oai:doaj.org/article:9917a7e6317a432fb6ef6fc4293bbeef 2024-09-15T18:39:26+00:00 A case control study of the relationship between persistent serum creatine kinase elevation and polyneuropathy Svein I. Bekkelund Karin Abeler Hallvard Lilleng Sissel Løseth 2024-06-01T00:00:00Z https://doi.org/10.1038/s41598-024-64555-x https://doaj.org/article/9917a7e6317a432fb6ef6fc4293bbeef EN eng Nature Portfolio https://doi.org/10.1038/s41598-024-64555-x https://doaj.org/toc/2045-2322 doi:10.1038/s41598-024-64555-x 2045-2322 https://doaj.org/article/9917a7e6317a432fb6ef6fc4293bbeef Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024) Creatine kinase HyperCKemia Nerve conduction study Electromyography Polyneuropathy Medicine R Science Q article 2024 ftdoajarticles https://doi.org/10.1038/s41598-024-64555-x 2024-08-05T17:49:11Z Abstract Creatine kinase (CK) has been associated with neuropathy, but the mechanisms are uncertain. We hypothesized that peripheral nerve function is impaired in subjects with persistent CK elevation (hyperCKemia) compared to age- and sex matched controls in a general population. The participants were recruited from the population based Tromsø study in Norway. Neuropathy impairment score (NIS), nerve conduction studies (NCS) and electromyography (EMG) in subjects with persistent hyperCKemia (n = 113; 51 men, 62 women) and controls (n = 128; 61 men, 67 women) were performed. The hyperCKemia group had higher NIS score than the controls (p = 0.050). NCS of the tibial nerve showed decreased compound motor action potential amplitude (p < 0.001), decreased motor conduction velocity (p < 0.001) and increased F-wave latency (p = 0.044). Also, reduced sensory amplitudes of the median, ulnar, and sural nerves were found. EMG showed significantly increased average motor unit potential amplitude in all examined muscles. CK correlated positively with glycated hemoglobin and non-fasting glucose in the hyperCKemia group, although not when controlled for covariates. The length dependent polyneuropathy demonstrated in the hyperCKemia group is unexplained, but CK leakage and involvement of glucose metabolism are speculated on. Article in Journal/Newspaper Tromsø Directory of Open Access Journals: DOAJ Articles Scientific Reports 14 1 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
topic |
Creatine kinase HyperCKemia Nerve conduction study Electromyography Polyneuropathy Medicine R Science Q |
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Creatine kinase HyperCKemia Nerve conduction study Electromyography Polyneuropathy Medicine R Science Q Svein I. Bekkelund Karin Abeler Hallvard Lilleng Sissel Løseth A case control study of the relationship between persistent serum creatine kinase elevation and polyneuropathy |
topic_facet |
Creatine kinase HyperCKemia Nerve conduction study Electromyography Polyneuropathy Medicine R Science Q |
description |
Abstract Creatine kinase (CK) has been associated with neuropathy, but the mechanisms are uncertain. We hypothesized that peripheral nerve function is impaired in subjects with persistent CK elevation (hyperCKemia) compared to age- and sex matched controls in a general population. The participants were recruited from the population based Tromsø study in Norway. Neuropathy impairment score (NIS), nerve conduction studies (NCS) and electromyography (EMG) in subjects with persistent hyperCKemia (n = 113; 51 men, 62 women) and controls (n = 128; 61 men, 67 women) were performed. The hyperCKemia group had higher NIS score than the controls (p = 0.050). NCS of the tibial nerve showed decreased compound motor action potential amplitude (p < 0.001), decreased motor conduction velocity (p < 0.001) and increased F-wave latency (p = 0.044). Also, reduced sensory amplitudes of the median, ulnar, and sural nerves were found. EMG showed significantly increased average motor unit potential amplitude in all examined muscles. CK correlated positively with glycated hemoglobin and non-fasting glucose in the hyperCKemia group, although not when controlled for covariates. The length dependent polyneuropathy demonstrated in the hyperCKemia group is unexplained, but CK leakage and involvement of glucose metabolism are speculated on. |
format |
Article in Journal/Newspaper |
author |
Svein I. Bekkelund Karin Abeler Hallvard Lilleng Sissel Løseth |
author_facet |
Svein I. Bekkelund Karin Abeler Hallvard Lilleng Sissel Løseth |
author_sort |
Svein I. Bekkelund |
title |
A case control study of the relationship between persistent serum creatine kinase elevation and polyneuropathy |
title_short |
A case control study of the relationship between persistent serum creatine kinase elevation and polyneuropathy |
title_full |
A case control study of the relationship between persistent serum creatine kinase elevation and polyneuropathy |
title_fullStr |
A case control study of the relationship between persistent serum creatine kinase elevation and polyneuropathy |
title_full_unstemmed |
A case control study of the relationship between persistent serum creatine kinase elevation and polyneuropathy |
title_sort |
case control study of the relationship between persistent serum creatine kinase elevation and polyneuropathy |
publisher |
Nature Portfolio |
publishDate |
2024 |
url |
https://doi.org/10.1038/s41598-024-64555-x https://doaj.org/article/9917a7e6317a432fb6ef6fc4293bbeef |
genre |
Tromsø |
genre_facet |
Tromsø |
op_source |
Scientific Reports, Vol 14, Iss 1, Pp 1-9 (2024) |
op_relation |
https://doi.org/10.1038/s41598-024-64555-x https://doaj.org/toc/2045-2322 doi:10.1038/s41598-024-64555-x 2045-2322 https://doaj.org/article/9917a7e6317a432fb6ef6fc4293bbeef |
op_doi |
https://doi.org/10.1038/s41598-024-64555-x |
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Scientific Reports |
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14 |
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1 |
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1810483811150987264 |