Antisocial Personality Disorder Among Patients in Treatment for Alcohol Use Disorder (AUD): Characteristics and Predictors of Early Relapse or Drop-Out

• Main Authors: Pandey S, Bolstad I, Lien L, Bramness JG
• Format: Article in Journal/Newspaper
• Language: English
• Published: Dove Medical Press 2021
• Subjects: alcohol use disorder; antisocial personality disorder; relapse; drop-out; Public aspects of medicine; RA1-1270; Arctic; Ingeborg; Norway; Tromsø
• Online Access: https://doaj.org/article/9907772feac04e87848ab2e91358f2fe

Susmita Pandey,1,2 Ingeborg Bolstad,1 Lars Lien,1,3 Jørgen G Bramness1,4,5 1Norwegian National Advisory Unit on Concurrent Substance Abuse and Mental Health Disorders, Innlandet Hospital Trust, Brumunddal, Norway; 2Institute of Clinical Medicine, University of Oslo, Oslo, Norway; 3Department of Health and Social Science, Innlandet University of Applied Science, Elverum, Norway; 4Department of Clinical Medicine, UiT – Norway’s Arctic University, Tromsø, Norway; 5Norwegian Institute of Public Health, Oslo, NorwayCorrespondence: Susmita Pandey Email [e-mail]: Patients with alcohol use disorders (AUD) vary significantly in many clinically important characteristics making them a heterogenous group. AUD patients with comorbid antisocial personality disorder (ASPD) form an important sub-group, and studies indicate that these patients may have poorer treatment outcomes. Therefore, we aimed to investigate the characteristics of AUD inpatients with comorbid ASPD and identify predictors of early relapse or treatment drop-out in these patients.Methods: In a longitudinal study of AUD patients (n = 113; 30 females; aged 27 to 72 years) in treatment at three residential rehabilitation clinics in Norway, we used interviews and self-report questionnaires to collect data on alcohol use, mental health, and trauma experience. In addition, we assessed biochemical parameters. The patients were followed up at 6 weeks to identify early relapse or drop-out.Results: Prevalence of ASPD among AUD patients was 15%. AUD patients with comorbid ASPD were exclusively male, of younger age, and reported more childhood trauma, and adult attention-deficit-hyperactivity-disorder symptoms. They reported more hazardous drinking behavior and more often had dependence on substances in addition to alcohol. The presence of ASPD did not predict early relapse or drop-out. However, early relapse or drop-out in ASPD patients was associated with childhood and adult trauma, younger age of drinking debut, and higher baseline prolactin ...