Chemotherapy in the treatment, control, and elimination of human onchocerciasis
Tarig B Higazi,1 Timothy G Geary,2 Charles D Mackenzie3,41Department of Biological Sciences, Ohio University Zanesville, Zanesville, OH, USA; 2Institute of Parasitology, McGill University, Montreal, QC, Canada; 3Center for Neglected Tropical Diseases, Liverpool School of Tropical Medicine, Liverpool...
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ftdoajarticles:oai:doaj.org/article:98f7c1c2db6147a0a1f7840a86e40ab4 2023-05-15T15:13:46+02:00 Chemotherapy in the treatment, control, and elimination of human onchocerciasis Higazi TB Geary TG Mackenzie CD 2014-10-01T00:00:00Z https://doaj.org/article/98f7c1c2db6147a0a1f7840a86e40ab4 EN eng Dove Medical Press http://www.dovepress.com/chemotherapy-in-the-treatment-control-and-elimination-of-human-onchoce-peer-reviewed-article-RRTM https://doaj.org/toc/1179-7282 1179-7282 https://doaj.org/article/98f7c1c2db6147a0a1f7840a86e40ab4 Research and Reports in Tropical Medicine, Vol 2014, Iss default, Pp 77-93 (2014) Arctic medicine. Tropical medicine RC955-962 article 2014 ftdoajarticles 2022-12-31T08:34:14Z Tarig B Higazi,1 Timothy G Geary,2 Charles D Mackenzie3,41Department of Biological Sciences, Ohio University Zanesville, Zanesville, OH, USA; 2Institute of Parasitology, McGill University, Montreal, QC, Canada; 3Center for Neglected Tropical Diseases, Liverpool School of Tropical Medicine, Liverpool, UK; 4Department of Pathobiology & Diagnostic Investigation, Michigan State University, East Lansing, MI, USAAbstract: Onchocerciasis treatment is one of the most positive stories in tropical medicine although major challenges remain to reaching the ultimate goal of disease elimination. Such challenges are to be expected when the therapeutic goal is to kill and safely remove a large multistage, efficient, metazoan infectious agent such as Onchocerca volvulus that has an exceptionally complicated relationship with its host. Successful control of onchocerciasis has often been hampered by host reactions following chemotherapy, that can sometimes cause significant tissue pathology. Presence of other filariae, particularly Loa loa, in endemic onchocerciasis-treatment areas also poses severe problems due to adverse reactions caused by drug-induced death of the coincident microfilariae of this usually clinically benign species. Although ivermectin has been very successful, there is a need to enhance the progress toward elimination of onchocerciasis; new drugs and their efficient use are keys to this. The permanent absence of Onchocerca microfilaridermia, defined as the lack of resurgence of skin microfilarial loads after treatment, is the ultimate characteristic of a useful new chemotherapeutic agent. Several drugs are under investigation to achieve this, including the reassessment of currently available and previously tested agents, such as the antibiotic, doxycycline, which targets the adult parasites through its anti-Wolbachia endosymbiont activity. Flubendazole, a benzimidazole derivative approved for treatment of human gastrointestinal nematodes, is also being considered for repurposing as a macrofilaricide to aid ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Canada Lansing ENVELOPE(-133.476,-133.476,63.744,63.744) |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Higazi TB Geary TG Mackenzie CD Chemotherapy in the treatment, control, and elimination of human onchocerciasis |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 |
description |
Tarig B Higazi,1 Timothy G Geary,2 Charles D Mackenzie3,41Department of Biological Sciences, Ohio University Zanesville, Zanesville, OH, USA; 2Institute of Parasitology, McGill University, Montreal, QC, Canada; 3Center for Neglected Tropical Diseases, Liverpool School of Tropical Medicine, Liverpool, UK; 4Department of Pathobiology & Diagnostic Investigation, Michigan State University, East Lansing, MI, USAAbstract: Onchocerciasis treatment is one of the most positive stories in tropical medicine although major challenges remain to reaching the ultimate goal of disease elimination. Such challenges are to be expected when the therapeutic goal is to kill and safely remove a large multistage, efficient, metazoan infectious agent such as Onchocerca volvulus that has an exceptionally complicated relationship with its host. Successful control of onchocerciasis has often been hampered by host reactions following chemotherapy, that can sometimes cause significant tissue pathology. Presence of other filariae, particularly Loa loa, in endemic onchocerciasis-treatment areas also poses severe problems due to adverse reactions caused by drug-induced death of the coincident microfilariae of this usually clinically benign species. Although ivermectin has been very successful, there is a need to enhance the progress toward elimination of onchocerciasis; new drugs and their efficient use are keys to this. The permanent absence of Onchocerca microfilaridermia, defined as the lack of resurgence of skin microfilarial loads after treatment, is the ultimate characteristic of a useful new chemotherapeutic agent. Several drugs are under investigation to achieve this, including the reassessment of currently available and previously tested agents, such as the antibiotic, doxycycline, which targets the adult parasites through its anti-Wolbachia endosymbiont activity. Flubendazole, a benzimidazole derivative approved for treatment of human gastrointestinal nematodes, is also being considered for repurposing as a macrofilaricide to aid ... |
format |
Article in Journal/Newspaper |
author |
Higazi TB Geary TG Mackenzie CD |
author_facet |
Higazi TB Geary TG Mackenzie CD |
author_sort |
Higazi TB |
title |
Chemotherapy in the treatment, control, and elimination of human onchocerciasis |
title_short |
Chemotherapy in the treatment, control, and elimination of human onchocerciasis |
title_full |
Chemotherapy in the treatment, control, and elimination of human onchocerciasis |
title_fullStr |
Chemotherapy in the treatment, control, and elimination of human onchocerciasis |
title_full_unstemmed |
Chemotherapy in the treatment, control, and elimination of human onchocerciasis |
title_sort |
chemotherapy in the treatment, control, and elimination of human onchocerciasis |
publisher |
Dove Medical Press |
publishDate |
2014 |
url |
https://doaj.org/article/98f7c1c2db6147a0a1f7840a86e40ab4 |
long_lat |
ENVELOPE(-133.476,-133.476,63.744,63.744) |
geographic |
Arctic Canada Lansing |
geographic_facet |
Arctic Canada Lansing |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Research and Reports in Tropical Medicine, Vol 2014, Iss default, Pp 77-93 (2014) |
op_relation |
http://www.dovepress.com/chemotherapy-in-the-treatment-control-and-elimination-of-human-onchoce-peer-reviewed-article-RRTM https://doaj.org/toc/1179-7282 1179-7282 https://doaj.org/article/98f7c1c2db6147a0a1f7840a86e40ab4 |
_version_ |
1766344291513270272 |