Chronic sequelae complicate convalescence from both dengue and acute viral respiratory illness.
Long Covid has raised awareness of the potentially disabling chronic sequelae that afflicts patients after acute viral infection. Similar syndromes of post-infectious sequelae have also been observed after other viral infections such as dengue, but their true prevalence and functional impact remain...
Published in: | PLOS Neglected Tropical Diseases |
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ftdoajarticles:oai:doaj.org/article:98d09964af0e4f72bf1213cbe097dd80 2023-05-15T15:15:27+02:00 Chronic sequelae complicate convalescence from both dengue and acute viral respiratory illness. Shirin Kalimuddin Yii Ean Teh Liang En Wee Shay Paintal Ram Sasisekharan Jenny G Low Sujata K Sheth Eng Eong Ooi 2022-08-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0010724 https://doaj.org/article/98d09964af0e4f72bf1213cbe097dd80 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0010724 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0010724 https://doaj.org/article/98d09964af0e4f72bf1213cbe097dd80 PLoS Neglected Tropical Diseases, Vol 16, Iss 8, p e0010724 (2022) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2022 ftdoajarticles https://doi.org/10.1371/journal.pntd.0010724 2022-12-31T00:05:24Z Long Covid has raised awareness of the potentially disabling chronic sequelae that afflicts patients after acute viral infection. Similar syndromes of post-infectious sequelae have also been observed after other viral infections such as dengue, but their true prevalence and functional impact remain poorly defined. We prospectively enrolled 209 patients with acute dengue (n = 48; one with severe dengue) and other acute viral respiratory infections (ARI) (n = 161), and followed them up for chronic sequelae up to one year post-enrolment, prior to the onset of the Covid-19 pandemic. Baseline demographics and co-morbidities were balanced between both groups except for gender, with more males in the dengue cohort (63% vs 29%, p<0.001). Except for the first visit, data on symptoms were collected remotely using a purpose-built mobile phone application. Mental health outcomes were evaluated using the validated SF-12v2 Health Survey. Almost all patients (95.8% of dengue and 94.4% of ARI patients) experienced at least one symptom of fatigue, somnolence, headache, concentration impairment or memory impairment within the first week of enrolment. Amongst patients with at least 3-months of follow-up, 18.0% in the dengue cohort and 14.6% in the ARI cohort experienced persistent symptoms. The median month-3 SF-12v2 Mental Component Summary Score was lower in patients who remained symptomatic at 3 months and beyond, compared to those whose symptoms fully resolved (47.7 vs. 56.0, p<0.001), indicating that patients who self-reported persistence of symptoms also experienced functionally worse mental health. No statistically significant difference in age, gender distribution or hospitalisation status was observed between those with and without chronic sequelae. Our findings reveal an under-appreciated burden of post-infection chronic sequelae in dengue and ARI patients. They call for studies to define the pathophysiology of this condition, and determine the efficacy of both vaccines as well as antiviral drugs in preventing such ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Ari ENVELOPE(147.813,147.813,59.810,59.810) PLOS Neglected Tropical Diseases 16 8 e0010724 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
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English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Shirin Kalimuddin Yii Ean Teh Liang En Wee Shay Paintal Ram Sasisekharan Jenny G Low Sujata K Sheth Eng Eong Ooi Chronic sequelae complicate convalescence from both dengue and acute viral respiratory illness. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Long Covid has raised awareness of the potentially disabling chronic sequelae that afflicts patients after acute viral infection. Similar syndromes of post-infectious sequelae have also been observed after other viral infections such as dengue, but their true prevalence and functional impact remain poorly defined. We prospectively enrolled 209 patients with acute dengue (n = 48; one with severe dengue) and other acute viral respiratory infections (ARI) (n = 161), and followed them up for chronic sequelae up to one year post-enrolment, prior to the onset of the Covid-19 pandemic. Baseline demographics and co-morbidities were balanced between both groups except for gender, with more males in the dengue cohort (63% vs 29%, p<0.001). Except for the first visit, data on symptoms were collected remotely using a purpose-built mobile phone application. Mental health outcomes were evaluated using the validated SF-12v2 Health Survey. Almost all patients (95.8% of dengue and 94.4% of ARI patients) experienced at least one symptom of fatigue, somnolence, headache, concentration impairment or memory impairment within the first week of enrolment. Amongst patients with at least 3-months of follow-up, 18.0% in the dengue cohort and 14.6% in the ARI cohort experienced persistent symptoms. The median month-3 SF-12v2 Mental Component Summary Score was lower in patients who remained symptomatic at 3 months and beyond, compared to those whose symptoms fully resolved (47.7 vs. 56.0, p<0.001), indicating that patients who self-reported persistence of symptoms also experienced functionally worse mental health. No statistically significant difference in age, gender distribution or hospitalisation status was observed between those with and without chronic sequelae. Our findings reveal an under-appreciated burden of post-infection chronic sequelae in dengue and ARI patients. They call for studies to define the pathophysiology of this condition, and determine the efficacy of both vaccines as well as antiviral drugs in preventing such ... |
format |
Article in Journal/Newspaper |
author |
Shirin Kalimuddin Yii Ean Teh Liang En Wee Shay Paintal Ram Sasisekharan Jenny G Low Sujata K Sheth Eng Eong Ooi |
author_facet |
Shirin Kalimuddin Yii Ean Teh Liang En Wee Shay Paintal Ram Sasisekharan Jenny G Low Sujata K Sheth Eng Eong Ooi |
author_sort |
Shirin Kalimuddin |
title |
Chronic sequelae complicate convalescence from both dengue and acute viral respiratory illness. |
title_short |
Chronic sequelae complicate convalescence from both dengue and acute viral respiratory illness. |
title_full |
Chronic sequelae complicate convalescence from both dengue and acute viral respiratory illness. |
title_fullStr |
Chronic sequelae complicate convalescence from both dengue and acute viral respiratory illness. |
title_full_unstemmed |
Chronic sequelae complicate convalescence from both dengue and acute viral respiratory illness. |
title_sort |
chronic sequelae complicate convalescence from both dengue and acute viral respiratory illness. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2022 |
url |
https://doi.org/10.1371/journal.pntd.0010724 https://doaj.org/article/98d09964af0e4f72bf1213cbe097dd80 |
long_lat |
ENVELOPE(147.813,147.813,59.810,59.810) |
geographic |
Arctic Ari |
geographic_facet |
Arctic Ari |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 16, Iss 8, p e0010724 (2022) |
op_relation |
https://doi.org/10.1371/journal.pntd.0010724 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0010724 https://doaj.org/article/98d09964af0e4f72bf1213cbe097dd80 |
op_doi |
https://doi.org/10.1371/journal.pntd.0010724 |
container_title |
PLOS Neglected Tropical Diseases |
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16 |
container_issue |
8 |
container_start_page |
e0010724 |
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