Characterization of potential drug-drug interactions in patients hospitalized in the intensive care unit of a tertiary hospital in Bogotá
Introduction: Drug-drug interactions occur more frequently in intensive care units than in other services. However, in Colombia, there are few studies on this problem in critically ill patients. Objectives: To characterize potential drug-drug interactions generated from prescriptions during hospital...
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ftdoajarticles:oai:doaj.org/article:98639e80819e4fae9c0f179b7ece8443 2023-05-15T15:11:00+02:00 Characterization of potential drug-drug interactions in patients hospitalized in the intensive care unit of a tertiary hospital in Bogotá Marcela Hernández Gabriel Tribiño Carlos Bustamante 2018-09-01T00:00:00Z https://doi.org/10.7705/biomedica.v38i4.3884 https://doaj.org/article/98639e80819e4fae9c0f179b7ece8443 EN ES eng spa Instituto Nacional de Salud https://www.revistabiomedica.org/index.php/biomedica/article/view/3884 https://doaj.org/toc/0120-4157 0120-4157 doi:10.7705/biomedica.v38i4.3884 https://doaj.org/article/98639e80819e4fae9c0f179b7ece8443 Biomédica: revista del Instituto Nacional de Salud, Vol 38, Iss 3, Pp 407-416 (2018) interacciones medicamentosas cuidados críticos prescripciones de medicamentos incidencia factores de riesgo estudios de cohortes Medicine R Arctic medicine. Tropical medicine RC955-962 article 2018 ftdoajarticles https://doi.org/10.7705/biomedica.v38i4.3884 2022-12-30T23:56:36Z Introduction: Drug-drug interactions occur more frequently in intensive care units than in other services. However, in Colombia, there are few studies on this problem in critically ill patients. Objectives: To characterize potential drug-drug interactions generated from prescriptions during hospitalization in an intensive care unit and to determine factors associated with their onset. Materials and methods: A retrospective cohort was assembled with patients hospitalized in an intensive care unit for a seven-month period. The daily prescription was assessed for potential drugdrug interactions using the Lexicomp® program. We calculated the incidence of interactions, classified them by type, severity, and level of documentation, and evaluated the factors associated with their onset using logistic regression. Results: The proportion of patients with at least one interaction was 84% while 87% had more than one interaction; the median was six interactions per patient. The most frequent was fentanyl and midazolam (23%). Moderate interactions were the most frequent by severity (77.6%) and by documentation (52.6%). The most common index and precipitating drugs were midazolam (12%) and fentanyl (10.6%), respectively. Age (OR=3.1) and the number of drugs (OR=11.8) were associated with the occurrence of interactions. Conclusions: Given their high frequency and potential negative impact, the systematic monitoring of prescriptions in intensive care units to detect interactions is important. Such monitoring contributes to the rational use of medicines and to improve the quality of care. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Biomédica 38 3 407 416 |
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Directory of Open Access Journals: DOAJ Articles |
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language |
English Spanish |
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interacciones medicamentosas cuidados críticos prescripciones de medicamentos incidencia factores de riesgo estudios de cohortes Medicine R Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
interacciones medicamentosas cuidados críticos prescripciones de medicamentos incidencia factores de riesgo estudios de cohortes Medicine R Arctic medicine. Tropical medicine RC955-962 Marcela Hernández Gabriel Tribiño Carlos Bustamante Characterization of potential drug-drug interactions in patients hospitalized in the intensive care unit of a tertiary hospital in Bogotá |
topic_facet |
interacciones medicamentosas cuidados críticos prescripciones de medicamentos incidencia factores de riesgo estudios de cohortes Medicine R Arctic medicine. Tropical medicine RC955-962 |
description |
Introduction: Drug-drug interactions occur more frequently in intensive care units than in other services. However, in Colombia, there are few studies on this problem in critically ill patients. Objectives: To characterize potential drug-drug interactions generated from prescriptions during hospitalization in an intensive care unit and to determine factors associated with their onset. Materials and methods: A retrospective cohort was assembled with patients hospitalized in an intensive care unit for a seven-month period. The daily prescription was assessed for potential drugdrug interactions using the Lexicomp® program. We calculated the incidence of interactions, classified them by type, severity, and level of documentation, and evaluated the factors associated with their onset using logistic regression. Results: The proportion of patients with at least one interaction was 84% while 87% had more than one interaction; the median was six interactions per patient. The most frequent was fentanyl and midazolam (23%). Moderate interactions were the most frequent by severity (77.6%) and by documentation (52.6%). The most common index and precipitating drugs were midazolam (12%) and fentanyl (10.6%), respectively. Age (OR=3.1) and the number of drugs (OR=11.8) were associated with the occurrence of interactions. Conclusions: Given their high frequency and potential negative impact, the systematic monitoring of prescriptions in intensive care units to detect interactions is important. Such monitoring contributes to the rational use of medicines and to improve the quality of care. |
format |
Article in Journal/Newspaper |
author |
Marcela Hernández Gabriel Tribiño Carlos Bustamante |
author_facet |
Marcela Hernández Gabriel Tribiño Carlos Bustamante |
author_sort |
Marcela Hernández |
title |
Characterization of potential drug-drug interactions in patients hospitalized in the intensive care unit of a tertiary hospital in Bogotá |
title_short |
Characterization of potential drug-drug interactions in patients hospitalized in the intensive care unit of a tertiary hospital in Bogotá |
title_full |
Characterization of potential drug-drug interactions in patients hospitalized in the intensive care unit of a tertiary hospital in Bogotá |
title_fullStr |
Characterization of potential drug-drug interactions in patients hospitalized in the intensive care unit of a tertiary hospital in Bogotá |
title_full_unstemmed |
Characterization of potential drug-drug interactions in patients hospitalized in the intensive care unit of a tertiary hospital in Bogotá |
title_sort |
characterization of potential drug-drug interactions in patients hospitalized in the intensive care unit of a tertiary hospital in bogotá |
publisher |
Instituto Nacional de Salud |
publishDate |
2018 |
url |
https://doi.org/10.7705/biomedica.v38i4.3884 https://doaj.org/article/98639e80819e4fae9c0f179b7ece8443 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Biomédica: revista del Instituto Nacional de Salud, Vol 38, Iss 3, Pp 407-416 (2018) |
op_relation |
https://www.revistabiomedica.org/index.php/biomedica/article/view/3884 https://doaj.org/toc/0120-4157 0120-4157 doi:10.7705/biomedica.v38i4.3884 https://doaj.org/article/98639e80819e4fae9c0f179b7ece8443 |
op_doi |
https://doi.org/10.7705/biomedica.v38i4.3884 |
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Biomédica |
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38 |
container_issue |
3 |
container_start_page |
407 |
op_container_end_page |
416 |
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1766341917562372096 |