Molecular epidemiology and genetic variation of pathogenic Vibrio parahaemolyticus in Peru.
Vibrio parahaemolyticus is a foodborne pathogen that has become a public health concern at the global scale. The epidemiological significance of V. parahaemolyticus infections in Latin America received little attention until the winter of 1997 when cases related to the pandemic clone were detected i...
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ftdoajarticles:oai:doaj.org/article:9844cb3a45044487a47640decc0b26f8 2023-05-15T15:13:28+02:00 Molecular epidemiology and genetic variation of pathogenic Vibrio parahaemolyticus in Peru. Ronnie G Gavilan Maria L Zamudio Jaime Martinez-Urtaza 2013-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0002210 https://doaj.org/article/9844cb3a45044487a47640decc0b26f8 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC3656152?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0002210 https://doaj.org/article/9844cb3a45044487a47640decc0b26f8 PLoS Neglected Tropical Diseases, Vol 7, Iss 5, p e2210 (2013) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2013 ftdoajarticles https://doi.org/10.1371/journal.pntd.0002210 2022-12-31T10:27:02Z Vibrio parahaemolyticus is a foodborne pathogen that has become a public health concern at the global scale. The epidemiological significance of V. parahaemolyticus infections in Latin America received little attention until the winter of 1997 when cases related to the pandemic clone were detected in the region, changing the epidemic dynamics of this pathogen in Peru. With the aim to assess the impact of the arrival of the pandemic clone on local populations of pathogenic V. parahaemolyticus in Peru, we investigated the population genetics and genomic variation in a complete collection of non-pandemic strains recovered from clinical sources in Peru during the pre- and post-emergence periods of the pandemic clone. A total of 56 clinical strains isolated in Peru during the period 1994 to 2007, 13 strains from Chile and 20 strains from Asia were characterized by Multilocus Sequence Typing (MLST) and checked for the presence of Variable Genomic Regions (VGRs). The emergence of O3:K6 cases in Peru implied a drastic disruption of the seasonal dynamics of infections and a shift in the serotype dominance of pathogenic V. parahaemolyticus. After the arrival of the pandemic clone, a great diversity of serovars not previously reported was detected in the country, which supports the introduction of additional populations cohabitating with the pandemic group. Moreover, the presence of genomic regions characteristic of the pandemic clone in other non-pandemic strains may represent early evidence of genetic transfer from the introduced population to the local communities. Finally, the results of this study stress the importance of population admixture, horizontal genetic transfer and homologous recombination as major events shaping the structure and diversity of pathogenic V. parahaemolyticus. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 7 5 e2210 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Ronnie G Gavilan Maria L Zamudio Jaime Martinez-Urtaza Molecular epidemiology and genetic variation of pathogenic Vibrio parahaemolyticus in Peru. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Vibrio parahaemolyticus is a foodborne pathogen that has become a public health concern at the global scale. The epidemiological significance of V. parahaemolyticus infections in Latin America received little attention until the winter of 1997 when cases related to the pandemic clone were detected in the region, changing the epidemic dynamics of this pathogen in Peru. With the aim to assess the impact of the arrival of the pandemic clone on local populations of pathogenic V. parahaemolyticus in Peru, we investigated the population genetics and genomic variation in a complete collection of non-pandemic strains recovered from clinical sources in Peru during the pre- and post-emergence periods of the pandemic clone. A total of 56 clinical strains isolated in Peru during the period 1994 to 2007, 13 strains from Chile and 20 strains from Asia were characterized by Multilocus Sequence Typing (MLST) and checked for the presence of Variable Genomic Regions (VGRs). The emergence of O3:K6 cases in Peru implied a drastic disruption of the seasonal dynamics of infections and a shift in the serotype dominance of pathogenic V. parahaemolyticus. After the arrival of the pandemic clone, a great diversity of serovars not previously reported was detected in the country, which supports the introduction of additional populations cohabitating with the pandemic group. Moreover, the presence of genomic regions characteristic of the pandemic clone in other non-pandemic strains may represent early evidence of genetic transfer from the introduced population to the local communities. Finally, the results of this study stress the importance of population admixture, horizontal genetic transfer and homologous recombination as major events shaping the structure and diversity of pathogenic V. parahaemolyticus. |
format |
Article in Journal/Newspaper |
author |
Ronnie G Gavilan Maria L Zamudio Jaime Martinez-Urtaza |
author_facet |
Ronnie G Gavilan Maria L Zamudio Jaime Martinez-Urtaza |
author_sort |
Ronnie G Gavilan |
title |
Molecular epidemiology and genetic variation of pathogenic Vibrio parahaemolyticus in Peru. |
title_short |
Molecular epidemiology and genetic variation of pathogenic Vibrio parahaemolyticus in Peru. |
title_full |
Molecular epidemiology and genetic variation of pathogenic Vibrio parahaemolyticus in Peru. |
title_fullStr |
Molecular epidemiology and genetic variation of pathogenic Vibrio parahaemolyticus in Peru. |
title_full_unstemmed |
Molecular epidemiology and genetic variation of pathogenic Vibrio parahaemolyticus in Peru. |
title_sort |
molecular epidemiology and genetic variation of pathogenic vibrio parahaemolyticus in peru. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2013 |
url |
https://doi.org/10.1371/journal.pntd.0002210 https://doaj.org/article/9844cb3a45044487a47640decc0b26f8 |
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Arctic |
geographic_facet |
Arctic |
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Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 7, Iss 5, p e2210 (2013) |
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http://europepmc.org/articles/PMC3656152?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0002210 https://doaj.org/article/9844cb3a45044487a47640decc0b26f8 |
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https://doi.org/10.1371/journal.pntd.0002210 |
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PLoS Neglected Tropical Diseases |
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