Prevalence and diversity of small mammal-associated Bartonella species in rural and urban Kenya.
Several rodent-associated Bartonella species are human pathogens but little is known about their epidemiology. We trapped rodents and shrews around human habitations at two sites in Kenya (rural Asembo and urban Kibera) to determine the prevalence of Bartonella infection. Bartonella were detected by...
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ftdoajarticles:oai:doaj.org/article:9829543bf5dd48b5adf26c100f7c5ecb 2023-05-15T15:08:38+02:00 Prevalence and diversity of small mammal-associated Bartonella species in rural and urban Kenya. Jo E B Halliday Darryn L Knobel Bernard Agwanda Ying Bai Robert F Breiman Sarah Cleaveland M Kariuki Njenga Michael Kosoy 2015-03-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0003608 https://doaj.org/article/9829543bf5dd48b5adf26c100f7c5ecb EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC4362764?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0003608 https://doaj.org/article/9829543bf5dd48b5adf26c100f7c5ecb PLoS Neglected Tropical Diseases, Vol 9, Iss 3, p e0003608 (2015) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2015 ftdoajarticles https://doi.org/10.1371/journal.pntd.0003608 2022-12-31T03:22:24Z Several rodent-associated Bartonella species are human pathogens but little is known about their epidemiology. We trapped rodents and shrews around human habitations at two sites in Kenya (rural Asembo and urban Kibera) to determine the prevalence of Bartonella infection. Bartonella were detected by culture in five of seven host species. In Kibera, 60% of Rattus rattus were positive, as compared to 13% in Asembo. Bartonella were also detected in C. olivieri (7%), Lemniscomys striatus (50%), Mastomys natalensis (43%) and R. norvegicus (50%). Partial sequencing of the citrate synthase (gltA) gene of isolates showed that Kibera strains were similar to reference isolates from Rattus trapped in Asia, America, and Europe, but that most strains from Asembo were less similar. Host species and trapping location were associated with differences in infection status but there was no evidence of associations between host age or sex and infection status. Acute febrile illness occurs at high incidence in both Asembo and Kibera but the etiology of many of these illnesses is unknown. Bartonella similar to known human pathogens were detected in small mammals at both sites and investigation of the ecological determinants of host infection status and of the public health significance of Bartonella infections at these locations is warranted. Article in Journal/Newspaper Arctic Rattus rattus Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 9 3 e0003608 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Jo E B Halliday Darryn L Knobel Bernard Agwanda Ying Bai Robert F Breiman Sarah Cleaveland M Kariuki Njenga Michael Kosoy Prevalence and diversity of small mammal-associated Bartonella species in rural and urban Kenya. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Several rodent-associated Bartonella species are human pathogens but little is known about their epidemiology. We trapped rodents and shrews around human habitations at two sites in Kenya (rural Asembo and urban Kibera) to determine the prevalence of Bartonella infection. Bartonella were detected by culture in five of seven host species. In Kibera, 60% of Rattus rattus were positive, as compared to 13% in Asembo. Bartonella were also detected in C. olivieri (7%), Lemniscomys striatus (50%), Mastomys natalensis (43%) and R. norvegicus (50%). Partial sequencing of the citrate synthase (gltA) gene of isolates showed that Kibera strains were similar to reference isolates from Rattus trapped in Asia, America, and Europe, but that most strains from Asembo were less similar. Host species and trapping location were associated with differences in infection status but there was no evidence of associations between host age or sex and infection status. Acute febrile illness occurs at high incidence in both Asembo and Kibera but the etiology of many of these illnesses is unknown. Bartonella similar to known human pathogens were detected in small mammals at both sites and investigation of the ecological determinants of host infection status and of the public health significance of Bartonella infections at these locations is warranted. |
format |
Article in Journal/Newspaper |
author |
Jo E B Halliday Darryn L Knobel Bernard Agwanda Ying Bai Robert F Breiman Sarah Cleaveland M Kariuki Njenga Michael Kosoy |
author_facet |
Jo E B Halliday Darryn L Knobel Bernard Agwanda Ying Bai Robert F Breiman Sarah Cleaveland M Kariuki Njenga Michael Kosoy |
author_sort |
Jo E B Halliday |
title |
Prevalence and diversity of small mammal-associated Bartonella species in rural and urban Kenya. |
title_short |
Prevalence and diversity of small mammal-associated Bartonella species in rural and urban Kenya. |
title_full |
Prevalence and diversity of small mammal-associated Bartonella species in rural and urban Kenya. |
title_fullStr |
Prevalence and diversity of small mammal-associated Bartonella species in rural and urban Kenya. |
title_full_unstemmed |
Prevalence and diversity of small mammal-associated Bartonella species in rural and urban Kenya. |
title_sort |
prevalence and diversity of small mammal-associated bartonella species in rural and urban kenya. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2015 |
url |
https://doi.org/10.1371/journal.pntd.0003608 https://doaj.org/article/9829543bf5dd48b5adf26c100f7c5ecb |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic Rattus rattus |
genre_facet |
Arctic Rattus rattus |
op_source |
PLoS Neglected Tropical Diseases, Vol 9, Iss 3, p e0003608 (2015) |
op_relation |
http://europepmc.org/articles/PMC4362764?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0003608 https://doaj.org/article/9829543bf5dd48b5adf26c100f7c5ecb |
op_doi |
https://doi.org/10.1371/journal.pntd.0003608 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
9 |
container_issue |
3 |
container_start_page |
e0003608 |
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1766339950245052416 |