Monitoring fluoroquinolone resistance among ESBL-positive and ESBL-negative Escherichia coli strains isolated from urinary tract infections: An alert for empirical treatment
ABSTRACT Background: Bacterial resistance to extended-spectrum beta-lactamases (ESBL) is present worldwide. Empirical antibiotic therapy is often needed, and the use of fluoroquinolones, such as ciprofloxacin and norfloxacin, is common. This study aimed to analyze the urine cultures from 2,680 outpa...
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Sociedade Brasileira de Medicina Tropical (SBMT)
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ftdoajarticles:oai:doaj.org/article:9813a5250ddc4cb6bffab8a6bcb1cbf1 2023-06-11T04:09:41+02:00 Monitoring fluoroquinolone resistance among ESBL-positive and ESBL-negative Escherichia coli strains isolated from urinary tract infections: An alert for empirical treatment Max Roberto Batista Araújo Lincoln de Oliveira Sant’Anna Nadir Nayara Carvalho dos Santos Luisa Ferreira Seabra Louisy Sanches dos Santos 2023-04-01T00:00:00Z https://doi.org/10.1590/0037-8682-0513-2022 https://doaj.org/article/9813a5250ddc4cb6bffab8a6bcb1cbf1 EN eng Sociedade Brasileira de Medicina Tropical (SBMT) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822023000100316&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0513-2022 https://doaj.org/article/9813a5250ddc4cb6bffab8a6bcb1cbf1 Revista da Sociedade Brasileira de Medicina Tropical, Vol 56 (2023) Fluoroquinolones Urinary tract infection Escherichia coli Drug resistance Arctic medicine. Tropical medicine RC955-962 article 2023 ftdoajarticles https://doi.org/10.1590/0037-8682-0513-2022 2023-04-23T00:35:04Z ABSTRACT Background: Bacterial resistance to extended-spectrum beta-lactamases (ESBL) is present worldwide. Empirical antibiotic therapy is often needed, and the use of fluoroquinolones, such as ciprofloxacin and norfloxacin, is common. This study aimed to analyze the urine cultures from 2,680 outpatients in January 2019, 2020, 2021, and 2022, with bacterial counts above 100,000 CFU/mL in which Escherichia coli was the etiological agent. Methods: We monitored the resistance of ESBL-positive and ESBL-negative strains to ciprofloxacin and norfloxacin and evaluated resistance rates. Results: Significantly higher fluoroquinolone resistance rates were observed among ESBL-positive strains in all years studied. Furthermore, a significant increase in the rate of fluoroquinolone resistance was observed between 2021 and 2022 in ESBL-positive and -negative strains, as well as from 2020 to 2021 among the ESBL-positive strains. Conclusions: The data obtained in the present study showed a tendency towards an increase in fluoroquinolone resistance among ESBL-positive and -negative E. coli strains isolated from urine cultures in Brazil. Since empirical antibiotic therapy with fluoroquinolones is commonly used to treat diverse types of infections, such as community-acquired urinary tract infections, this work highlights the need for continuous monitoring of fluoroquinolone resistance among E. coli strains circulating in the community, which can mitigate the frequency of therapeutic failures and development of widespread multidrug-resistant strains. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista da Sociedade Brasileira de Medicina Tropical 56 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Fluoroquinolones Urinary tract infection Escherichia coli Drug resistance Arctic medicine. Tropical medicine RC955-962 |
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Fluoroquinolones Urinary tract infection Escherichia coli Drug resistance Arctic medicine. Tropical medicine RC955-962 Max Roberto Batista Araújo Lincoln de Oliveira Sant’Anna Nadir Nayara Carvalho dos Santos Luisa Ferreira Seabra Louisy Sanches dos Santos Monitoring fluoroquinolone resistance among ESBL-positive and ESBL-negative Escherichia coli strains isolated from urinary tract infections: An alert for empirical treatment |
topic_facet |
Fluoroquinolones Urinary tract infection Escherichia coli Drug resistance Arctic medicine. Tropical medicine RC955-962 |
description |
ABSTRACT Background: Bacterial resistance to extended-spectrum beta-lactamases (ESBL) is present worldwide. Empirical antibiotic therapy is often needed, and the use of fluoroquinolones, such as ciprofloxacin and norfloxacin, is common. This study aimed to analyze the urine cultures from 2,680 outpatients in January 2019, 2020, 2021, and 2022, with bacterial counts above 100,000 CFU/mL in which Escherichia coli was the etiological agent. Methods: We monitored the resistance of ESBL-positive and ESBL-negative strains to ciprofloxacin and norfloxacin and evaluated resistance rates. Results: Significantly higher fluoroquinolone resistance rates were observed among ESBL-positive strains in all years studied. Furthermore, a significant increase in the rate of fluoroquinolone resistance was observed between 2021 and 2022 in ESBL-positive and -negative strains, as well as from 2020 to 2021 among the ESBL-positive strains. Conclusions: The data obtained in the present study showed a tendency towards an increase in fluoroquinolone resistance among ESBL-positive and -negative E. coli strains isolated from urine cultures in Brazil. Since empirical antibiotic therapy with fluoroquinolones is commonly used to treat diverse types of infections, such as community-acquired urinary tract infections, this work highlights the need for continuous monitoring of fluoroquinolone resistance among E. coli strains circulating in the community, which can mitigate the frequency of therapeutic failures and development of widespread multidrug-resistant strains. |
format |
Article in Journal/Newspaper |
author |
Max Roberto Batista Araújo Lincoln de Oliveira Sant’Anna Nadir Nayara Carvalho dos Santos Luisa Ferreira Seabra Louisy Sanches dos Santos |
author_facet |
Max Roberto Batista Araújo Lincoln de Oliveira Sant’Anna Nadir Nayara Carvalho dos Santos Luisa Ferreira Seabra Louisy Sanches dos Santos |
author_sort |
Max Roberto Batista Araújo |
title |
Monitoring fluoroquinolone resistance among ESBL-positive and ESBL-negative Escherichia coli strains isolated from urinary tract infections: An alert for empirical treatment |
title_short |
Monitoring fluoroquinolone resistance among ESBL-positive and ESBL-negative Escherichia coli strains isolated from urinary tract infections: An alert for empirical treatment |
title_full |
Monitoring fluoroquinolone resistance among ESBL-positive and ESBL-negative Escherichia coli strains isolated from urinary tract infections: An alert for empirical treatment |
title_fullStr |
Monitoring fluoroquinolone resistance among ESBL-positive and ESBL-negative Escherichia coli strains isolated from urinary tract infections: An alert for empirical treatment |
title_full_unstemmed |
Monitoring fluoroquinolone resistance among ESBL-positive and ESBL-negative Escherichia coli strains isolated from urinary tract infections: An alert for empirical treatment |
title_sort |
monitoring fluoroquinolone resistance among esbl-positive and esbl-negative escherichia coli strains isolated from urinary tract infections: an alert for empirical treatment |
publisher |
Sociedade Brasileira de Medicina Tropical (SBMT) |
publishDate |
2023 |
url |
https://doi.org/10.1590/0037-8682-0513-2022 https://doaj.org/article/9813a5250ddc4cb6bffab8a6bcb1cbf1 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista da Sociedade Brasileira de Medicina Tropical, Vol 56 (2023) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822023000100316&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/0037-8682-0513-2022 https://doaj.org/article/9813a5250ddc4cb6bffab8a6bcb1cbf1 |
op_doi |
https://doi.org/10.1590/0037-8682-0513-2022 |
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Revista da Sociedade Brasileira de Medicina Tropical |
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56 |
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