Assessment of Cardiac Autonomic Function in Relation to Methylmercury Neurotoxicity
After the European Food Safety Authority reviewed reports of methylmercury and heart rate variability (HRV) in 2012, the panel concluded that, although some studies of cardiac autonomy suggested an autonomic effect of methylmercury, the results were inconsistent among studies and the implications fo...
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ftdoajarticles:oai:doaj.org/article:97ff32fd54f04c08ac35143806a2f611 2023-05-15T16:10:55+02:00 Assessment of Cardiac Autonomic Function in Relation to Methylmercury Neurotoxicity Kanae Karita Toyoto Iwata Eri Maeda Mineshi Sakamoto Katsuyuki Murata 2018-07-01T00:00:00Z https://doi.org/10.3390/toxics6030038 https://doaj.org/article/97ff32fd54f04c08ac35143806a2f611 EN eng MDPI AG http://www.mdpi.com/2305-6304/6/3/38 https://doaj.org/toc/2305-6304 2305-6304 doi:10.3390/toxics6030038 https://doaj.org/article/97ff32fd54f04c08ac35143806a2f611 Toxics, Vol 6, Iss 3, p 38 (2018) heart rate variability methylmercury neurotoxicity review sympathodominant state Chemical technology TP1-1185 article 2018 ftdoajarticles https://doi.org/10.3390/toxics6030038 2022-12-31T09:36:00Z After the European Food Safety Authority reviewed reports of methylmercury and heart rate variability (HRV) in 2012, the panel concluded that, although some studies of cardiac autonomy suggested an autonomic effect of methylmercury, the results were inconsistent among studies and the implications for health were unclear. In this study, we reconsider this association by adding a perspective on the physiological context. Cardiovascular rhythmicity is usually studied within different frequency domains of HRV. Three spectral components are usually detected; in humans these are centered at <0.04 Hz, 0.15 Hz (LF), and 0.3 Hz (HF). LF and HF (sympathetic and parasympathetic activities, respectively) are evaluated in terms of frequency and power. By searching PubMed, we identified 13 studies examining the effect of methylmercury exposure on HRV in human populations in the Faroe Islands, the Seychelles and other countries. Considering both reduced HRV and sympathodominant state (i.e., lower HF, higher LF, or higher LF/HF ratio) as autonomic abnormality, eight of them showed the significant association with methylmercury exposure. Five studies failed to demonstrate any significant association. In conclusion, these data suggest that increased methylmercury exposure was consistently associated with autonomic abnormality, though the influence of methylmercury on HRV (e.g., LF) might differ for prenatal and postnatal exposures. The results with HRV should be included in the risk characterization of methylmercury. The HRV parameters calculated by frequency domain analysis appear to be more sensitive to methylmercury exposure than those by time domain analysis. Article in Journal/Newspaper Faroe Islands Directory of Open Access Journals: DOAJ Articles Faroe Islands Toxics 6 3 38 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
heart rate variability methylmercury neurotoxicity review sympathodominant state Chemical technology TP1-1185 |
spellingShingle |
heart rate variability methylmercury neurotoxicity review sympathodominant state Chemical technology TP1-1185 Kanae Karita Toyoto Iwata Eri Maeda Mineshi Sakamoto Katsuyuki Murata Assessment of Cardiac Autonomic Function in Relation to Methylmercury Neurotoxicity |
topic_facet |
heart rate variability methylmercury neurotoxicity review sympathodominant state Chemical technology TP1-1185 |
description |
After the European Food Safety Authority reviewed reports of methylmercury and heart rate variability (HRV) in 2012, the panel concluded that, although some studies of cardiac autonomy suggested an autonomic effect of methylmercury, the results were inconsistent among studies and the implications for health were unclear. In this study, we reconsider this association by adding a perspective on the physiological context. Cardiovascular rhythmicity is usually studied within different frequency domains of HRV. Three spectral components are usually detected; in humans these are centered at <0.04 Hz, 0.15 Hz (LF), and 0.3 Hz (HF). LF and HF (sympathetic and parasympathetic activities, respectively) are evaluated in terms of frequency and power. By searching PubMed, we identified 13 studies examining the effect of methylmercury exposure on HRV in human populations in the Faroe Islands, the Seychelles and other countries. Considering both reduced HRV and sympathodominant state (i.e., lower HF, higher LF, or higher LF/HF ratio) as autonomic abnormality, eight of them showed the significant association with methylmercury exposure. Five studies failed to demonstrate any significant association. In conclusion, these data suggest that increased methylmercury exposure was consistently associated with autonomic abnormality, though the influence of methylmercury on HRV (e.g., LF) might differ for prenatal and postnatal exposures. The results with HRV should be included in the risk characterization of methylmercury. The HRV parameters calculated by frequency domain analysis appear to be more sensitive to methylmercury exposure than those by time domain analysis. |
format |
Article in Journal/Newspaper |
author |
Kanae Karita Toyoto Iwata Eri Maeda Mineshi Sakamoto Katsuyuki Murata |
author_facet |
Kanae Karita Toyoto Iwata Eri Maeda Mineshi Sakamoto Katsuyuki Murata |
author_sort |
Kanae Karita |
title |
Assessment of Cardiac Autonomic Function in Relation to Methylmercury Neurotoxicity |
title_short |
Assessment of Cardiac Autonomic Function in Relation to Methylmercury Neurotoxicity |
title_full |
Assessment of Cardiac Autonomic Function in Relation to Methylmercury Neurotoxicity |
title_fullStr |
Assessment of Cardiac Autonomic Function in Relation to Methylmercury Neurotoxicity |
title_full_unstemmed |
Assessment of Cardiac Autonomic Function in Relation to Methylmercury Neurotoxicity |
title_sort |
assessment of cardiac autonomic function in relation to methylmercury neurotoxicity |
publisher |
MDPI AG |
publishDate |
2018 |
url |
https://doi.org/10.3390/toxics6030038 https://doaj.org/article/97ff32fd54f04c08ac35143806a2f611 |
geographic |
Faroe Islands |
geographic_facet |
Faroe Islands |
genre |
Faroe Islands |
genre_facet |
Faroe Islands |
op_source |
Toxics, Vol 6, Iss 3, p 38 (2018) |
op_relation |
http://www.mdpi.com/2305-6304/6/3/38 https://doaj.org/toc/2305-6304 2305-6304 doi:10.3390/toxics6030038 https://doaj.org/article/97ff32fd54f04c08ac35143806a2f611 |
op_doi |
https://doi.org/10.3390/toxics6030038 |
container_title |
Toxics |
container_volume |
6 |
container_issue |
3 |
container_start_page |
38 |
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1765996058383482880 |