Artemisinin-based combination therapy during pregnancy: outcome of pregnancy and infant mortality: a cohort study
Abstract Background The World Health Organization (WHO) recommendation of treating uncomplicated malaria during the second and third trimester of pregnancy with an artemisinin-based combination therapy (ACT) has already been implemented by all sub-Saharan African countries. However, there is limited...
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ftdoajarticles:oai:doaj.org/article:97907c2c2c6e44aa87e6712982951d8b 2023-05-15T15:10:54+02:00 Artemisinin-based combination therapy during pregnancy: outcome of pregnancy and infant mortality: a cohort study Michael Nambozi Halidou Tinto Victor Mwapasa Harry Tagbor Jean-Bertin Bukasa Kabuya Sebastian Hachizovu Maminata Traoré Innocent Valea Marc Christian Tahita Gifty Ampofo Jozefien Buyze Raffaella Ravinetto Diana Arango Kamala Thriemer Modest Mulenga Jean-Pierre van Geertruyden Umberto D’Alessandro 2019-03-01T00:00:00Z https://doi.org/10.1186/s12936-019-2737-7 https://doaj.org/article/97907c2c2c6e44aa87e6712982951d8b EN eng BMC http://link.springer.com/article/10.1186/s12936-019-2737-7 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-019-2737-7 1475-2875 https://doaj.org/article/97907c2c2c6e44aa87e6712982951d8b Malaria Journal, Vol 18, Iss 1, Pp 1-8 (2019) Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2019 ftdoajarticles https://doi.org/10.1186/s12936-019-2737-7 2022-12-31T05:41:29Z Abstract Background The World Health Organization (WHO) recommendation of treating uncomplicated malaria during the second and third trimester of pregnancy with an artemisinin-based combination therapy (ACT) has already been implemented by all sub-Saharan African countries. However, there is limited knowledge on the effect of ACT on pregnancy outcomes, and on newborn and infant’s health. Methods Pregnant women with malaria in four countries (Burkina Faso, Ghana, Malawi and Zambia) were treated with either artemether–lumefantrine (AL), amodiaquine–artesunate (ASAQ), mefloquine-artesunate (MQAS), or dihydroartemisinin–piperaquine (DHA–PQ); 3127 live new-borns (822 in the AL, 775 in the ASAQ, 765 in the MQAS and 765 in the DHAPQ arms) were followed-up until their first birthday. Results Prevalence of placental malaria and low birth weight were 28.0% (738/2646) and 16.0% (480/2999), respectively, with no significant differences between treatment arms. No differences in congenital malformations (p = 0.35), perinatal mortality (p = 0.77), neonatal mortality (p = 0.21), and infant mortality (p = 0.96) were found. Conclusions Outcome of pregnancy and infant survival were similar between treatment arms indicating that any of the four artemisinin-based combinations could be safely used during the second and third trimester of pregnancy without any adverse effect on the baby. Nevertheless, smaller safety differences between artemisinin-based combinations cannot be excluded; country-wide post-marketing surveillance would be very helpful to confirm such findings. Trial registration ClinicalTrials.gov, NCT00852423, Registered on 27 February 2009, https://clinicaltrials.gov/ct2/show/NCT00852423 Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 18 1 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Michael Nambozi Halidou Tinto Victor Mwapasa Harry Tagbor Jean-Bertin Bukasa Kabuya Sebastian Hachizovu Maminata Traoré Innocent Valea Marc Christian Tahita Gifty Ampofo Jozefien Buyze Raffaella Ravinetto Diana Arango Kamala Thriemer Modest Mulenga Jean-Pierre van Geertruyden Umberto D’Alessandro Artemisinin-based combination therapy during pregnancy: outcome of pregnancy and infant mortality: a cohort study |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background The World Health Organization (WHO) recommendation of treating uncomplicated malaria during the second and third trimester of pregnancy with an artemisinin-based combination therapy (ACT) has already been implemented by all sub-Saharan African countries. However, there is limited knowledge on the effect of ACT on pregnancy outcomes, and on newborn and infant’s health. Methods Pregnant women with malaria in four countries (Burkina Faso, Ghana, Malawi and Zambia) were treated with either artemether–lumefantrine (AL), amodiaquine–artesunate (ASAQ), mefloquine-artesunate (MQAS), or dihydroartemisinin–piperaquine (DHA–PQ); 3127 live new-borns (822 in the AL, 775 in the ASAQ, 765 in the MQAS and 765 in the DHAPQ arms) were followed-up until their first birthday. Results Prevalence of placental malaria and low birth weight were 28.0% (738/2646) and 16.0% (480/2999), respectively, with no significant differences between treatment arms. No differences in congenital malformations (p = 0.35), perinatal mortality (p = 0.77), neonatal mortality (p = 0.21), and infant mortality (p = 0.96) were found. Conclusions Outcome of pregnancy and infant survival were similar between treatment arms indicating that any of the four artemisinin-based combinations could be safely used during the second and third trimester of pregnancy without any adverse effect on the baby. Nevertheless, smaller safety differences between artemisinin-based combinations cannot be excluded; country-wide post-marketing surveillance would be very helpful to confirm such findings. Trial registration ClinicalTrials.gov, NCT00852423, Registered on 27 February 2009, https://clinicaltrials.gov/ct2/show/NCT00852423 |
format |
Article in Journal/Newspaper |
author |
Michael Nambozi Halidou Tinto Victor Mwapasa Harry Tagbor Jean-Bertin Bukasa Kabuya Sebastian Hachizovu Maminata Traoré Innocent Valea Marc Christian Tahita Gifty Ampofo Jozefien Buyze Raffaella Ravinetto Diana Arango Kamala Thriemer Modest Mulenga Jean-Pierre van Geertruyden Umberto D’Alessandro |
author_facet |
Michael Nambozi Halidou Tinto Victor Mwapasa Harry Tagbor Jean-Bertin Bukasa Kabuya Sebastian Hachizovu Maminata Traoré Innocent Valea Marc Christian Tahita Gifty Ampofo Jozefien Buyze Raffaella Ravinetto Diana Arango Kamala Thriemer Modest Mulenga Jean-Pierre van Geertruyden Umberto D’Alessandro |
author_sort |
Michael Nambozi |
title |
Artemisinin-based combination therapy during pregnancy: outcome of pregnancy and infant mortality: a cohort study |
title_short |
Artemisinin-based combination therapy during pregnancy: outcome of pregnancy and infant mortality: a cohort study |
title_full |
Artemisinin-based combination therapy during pregnancy: outcome of pregnancy and infant mortality: a cohort study |
title_fullStr |
Artemisinin-based combination therapy during pregnancy: outcome of pregnancy and infant mortality: a cohort study |
title_full_unstemmed |
Artemisinin-based combination therapy during pregnancy: outcome of pregnancy and infant mortality: a cohort study |
title_sort |
artemisinin-based combination therapy during pregnancy: outcome of pregnancy and infant mortality: a cohort study |
publisher |
BMC |
publishDate |
2019 |
url |
https://doi.org/10.1186/s12936-019-2737-7 https://doaj.org/article/97907c2c2c6e44aa87e6712982951d8b |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 18, Iss 1, Pp 1-8 (2019) |
op_relation |
http://link.springer.com/article/10.1186/s12936-019-2737-7 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-019-2737-7 1475-2875 https://doaj.org/article/97907c2c2c6e44aa87e6712982951d8b |
op_doi |
https://doi.org/10.1186/s12936-019-2737-7 |
container_title |
Malaria Journal |
container_volume |
18 |
container_issue |
1 |
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1766341835249156096 |