Estimating fiber orientation distribution functions in 3D-Polarized Light Imaging
Research of the human brain connectome requires multiscale approaches derived from independent imaging methods ideally applied to the same object. Hence, comprehensible strategies for data integration across modalities and across scales are essential. We have successfully established a concept to br...
Published in: | Frontiers in Neuroanatomy |
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Online Access: | https://doi.org/10.3389/fnana.2016.00040 https://doaj.org/article/9706edb4ca6c48e1837a390b8f565b7f |
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ftdoajarticles:oai:doaj.org/article:9706edb4ca6c48e1837a390b8f565b7f 2023-05-15T16:34:49+02:00 Estimating fiber orientation distribution functions in 3D-Polarized Light Imaging Markus eAxer Sven eStrohmer David eGräßel Oliver eBücker Melanie eDohmen Julia eReckfort Karl eZilles Katrin eAmunts 2016-04-01T00:00:00Z https://doi.org/10.3389/fnana.2016.00040 https://doaj.org/article/9706edb4ca6c48e1837a390b8f565b7f EN eng Frontiers Media S.A. http://journal.frontiersin.org/Journal/10.3389/fnana.2016.00040/full https://doaj.org/toc/1662-5129 1662-5129 doi:10.3389/fnana.2016.00040 https://doaj.org/article/9706edb4ca6c48e1837a390b8f565b7f Frontiers in Neuroanatomy, Vol 10 (2016) human brain connectome Polarized light imaging Fiber architecture 3D-PLI Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Human anatomy QM1-695 article 2016 ftdoajarticles https://doi.org/10.3389/fnana.2016.00040 2022-12-31T05:12:53Z Research of the human brain connectome requires multiscale approaches derived from independent imaging methods ideally applied to the same object. Hence, comprehensible strategies for data integration across modalities and across scales are essential. We have successfully established a concept to bridge the spatial scales from microscopic fiber orientation measurements based on 3D-Polarized Light Imaging (3D-PLI) to meso- or macroscopic dimensions. By creating orientation distribution functions (pliODFs) from high-resolution vector data via series expansion with spherical harmonics utilizing high performance computing and supercomputing technologies, data fusion with Diffusion Magnetic Resonance Imaging has become feasible, even for a large-scale dataset such as the human brain. Validation of our approach was done effectively by means of two types of datasets that were transferred from fiber orientation maps into pliODFs: simulated 3D-PLI data showing artificial, but clearly defined fiber patterns and real 3D-PLI data derived from sections through the human brain and the brain of a hooded seal. Article in Journal/Newspaper hooded seal Directory of Open Access Journals: DOAJ Articles Frontiers in Neuroanatomy 10 |
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Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
human brain connectome Polarized light imaging Fiber architecture 3D-PLI Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Human anatomy QM1-695 |
spellingShingle |
human brain connectome Polarized light imaging Fiber architecture 3D-PLI Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Human anatomy QM1-695 Markus eAxer Sven eStrohmer David eGräßel Oliver eBücker Melanie eDohmen Julia eReckfort Karl eZilles Katrin eAmunts Estimating fiber orientation distribution functions in 3D-Polarized Light Imaging |
topic_facet |
human brain connectome Polarized light imaging Fiber architecture 3D-PLI Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Human anatomy QM1-695 |
description |
Research of the human brain connectome requires multiscale approaches derived from independent imaging methods ideally applied to the same object. Hence, comprehensible strategies for data integration across modalities and across scales are essential. We have successfully established a concept to bridge the spatial scales from microscopic fiber orientation measurements based on 3D-Polarized Light Imaging (3D-PLI) to meso- or macroscopic dimensions. By creating orientation distribution functions (pliODFs) from high-resolution vector data via series expansion with spherical harmonics utilizing high performance computing and supercomputing technologies, data fusion with Diffusion Magnetic Resonance Imaging has become feasible, even for a large-scale dataset such as the human brain. Validation of our approach was done effectively by means of two types of datasets that were transferred from fiber orientation maps into pliODFs: simulated 3D-PLI data showing artificial, but clearly defined fiber patterns and real 3D-PLI data derived from sections through the human brain and the brain of a hooded seal. |
format |
Article in Journal/Newspaper |
author |
Markus eAxer Sven eStrohmer David eGräßel Oliver eBücker Melanie eDohmen Julia eReckfort Karl eZilles Katrin eAmunts |
author_facet |
Markus eAxer Sven eStrohmer David eGräßel Oliver eBücker Melanie eDohmen Julia eReckfort Karl eZilles Katrin eAmunts |
author_sort |
Markus eAxer |
title |
Estimating fiber orientation distribution functions in 3D-Polarized Light Imaging |
title_short |
Estimating fiber orientation distribution functions in 3D-Polarized Light Imaging |
title_full |
Estimating fiber orientation distribution functions in 3D-Polarized Light Imaging |
title_fullStr |
Estimating fiber orientation distribution functions in 3D-Polarized Light Imaging |
title_full_unstemmed |
Estimating fiber orientation distribution functions in 3D-Polarized Light Imaging |
title_sort |
estimating fiber orientation distribution functions in 3d-polarized light imaging |
publisher |
Frontiers Media S.A. |
publishDate |
2016 |
url |
https://doi.org/10.3389/fnana.2016.00040 https://doaj.org/article/9706edb4ca6c48e1837a390b8f565b7f |
genre |
hooded seal |
genre_facet |
hooded seal |
op_source |
Frontiers in Neuroanatomy, Vol 10 (2016) |
op_relation |
http://journal.frontiersin.org/Journal/10.3389/fnana.2016.00040/full https://doaj.org/toc/1662-5129 1662-5129 doi:10.3389/fnana.2016.00040 https://doaj.org/article/9706edb4ca6c48e1837a390b8f565b7f |
op_doi |
https://doi.org/10.3389/fnana.2016.00040 |
container_title |
Frontiers in Neuroanatomy |
container_volume |
10 |
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1766024857109135360 |