Fluctuations at a low mean temperature accelerate dengue virus transmission by Aedes aegypti.
BACKGROUND: Environmental factors such as temperature can alter mosquito vector competence for arboviruses. Results from recent studies indicate that daily fluctuations around an intermediate mean temperature (26°C) reduce vector competence of Aedes aeygpti for dengue viruses (DENV). Theoretical pre...
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ftdoajarticles:oai:doaj.org/article:96e73b6f129d4965b203daf6b1dd0560 2023-05-15T15:13:34+02:00 Fluctuations at a low mean temperature accelerate dengue virus transmission by Aedes aegypti. Lauren B Carrington M Veronica Armijos Louis Lambrechts Thomas W Scott 2013-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0002190 https://doaj.org/article/96e73b6f129d4965b203daf6b1dd0560 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC3636080?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0002190 https://doaj.org/article/96e73b6f129d4965b203daf6b1dd0560 PLoS Neglected Tropical Diseases, Vol 7, Iss 4, p e2190 (2013) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2013 ftdoajarticles https://doi.org/10.1371/journal.pntd.0002190 2022-12-31T16:02:53Z BACKGROUND: Environmental factors such as temperature can alter mosquito vector competence for arboviruses. Results from recent studies indicate that daily fluctuations around an intermediate mean temperature (26°C) reduce vector competence of Aedes aeygpti for dengue viruses (DENV). Theoretical predictions suggest that the mean temperature in combination with the magnitude of the diurnal temperature range (DTR) mediate the direction of these effects. METHODOLOGY/PRINCIPAL FINDINGS: We tested the effect of temperature fluctuations on Ae. aegypti vector competence for DENV serotype-1 at high and low mean temperatures, and confirmed this theoretical prediction. A small DTR had no effect on vector competence around a high (30°C) mean, but a large DTR at low temperature (20°C) increased the proportion of infected mosquitoes with a disseminated infection by 60% at 21 and 28 days post-exposure compared to a constant 20°C. This effect resulted from a marked shortening of DENV extrinsic incubation period (EIP) in its mosquito vector; i.e., a decrease from 29.6 to 18.9 days under the fluctuating vs. constant temperature treatment. CONCLUSIONS: Our results indicate that Ae. aegypti exposed to large fluctuations at low temperatures have a significantly shorter virus EIP than under constant temperature conditions at the same mean, leading to a considerably greater potential for DENV transmission. These results emphasize the value of accounting for daily temperature variation in an effort to more accurately understand and predict the risk of mosquito-borne pathogen transmission, provide a mechanism for sustained DENV transmission in endemic areas during cooler times of the year, and indicate that DENV transmission could be more efficient in temperate regions than previously anticipated. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 7 4 e2190 |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Lauren B Carrington M Veronica Armijos Louis Lambrechts Thomas W Scott Fluctuations at a low mean temperature accelerate dengue virus transmission by Aedes aegypti. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
BACKGROUND: Environmental factors such as temperature can alter mosquito vector competence for arboviruses. Results from recent studies indicate that daily fluctuations around an intermediate mean temperature (26°C) reduce vector competence of Aedes aeygpti for dengue viruses (DENV). Theoretical predictions suggest that the mean temperature in combination with the magnitude of the diurnal temperature range (DTR) mediate the direction of these effects. METHODOLOGY/PRINCIPAL FINDINGS: We tested the effect of temperature fluctuations on Ae. aegypti vector competence for DENV serotype-1 at high and low mean temperatures, and confirmed this theoretical prediction. A small DTR had no effect on vector competence around a high (30°C) mean, but a large DTR at low temperature (20°C) increased the proportion of infected mosquitoes with a disseminated infection by 60% at 21 and 28 days post-exposure compared to a constant 20°C. This effect resulted from a marked shortening of DENV extrinsic incubation period (EIP) in its mosquito vector; i.e., a decrease from 29.6 to 18.9 days under the fluctuating vs. constant temperature treatment. CONCLUSIONS: Our results indicate that Ae. aegypti exposed to large fluctuations at low temperatures have a significantly shorter virus EIP than under constant temperature conditions at the same mean, leading to a considerably greater potential for DENV transmission. These results emphasize the value of accounting for daily temperature variation in an effort to more accurately understand and predict the risk of mosquito-borne pathogen transmission, provide a mechanism for sustained DENV transmission in endemic areas during cooler times of the year, and indicate that DENV transmission could be more efficient in temperate regions than previously anticipated. |
format |
Article in Journal/Newspaper |
author |
Lauren B Carrington M Veronica Armijos Louis Lambrechts Thomas W Scott |
author_facet |
Lauren B Carrington M Veronica Armijos Louis Lambrechts Thomas W Scott |
author_sort |
Lauren B Carrington |
title |
Fluctuations at a low mean temperature accelerate dengue virus transmission by Aedes aegypti. |
title_short |
Fluctuations at a low mean temperature accelerate dengue virus transmission by Aedes aegypti. |
title_full |
Fluctuations at a low mean temperature accelerate dengue virus transmission by Aedes aegypti. |
title_fullStr |
Fluctuations at a low mean temperature accelerate dengue virus transmission by Aedes aegypti. |
title_full_unstemmed |
Fluctuations at a low mean temperature accelerate dengue virus transmission by Aedes aegypti. |
title_sort |
fluctuations at a low mean temperature accelerate dengue virus transmission by aedes aegypti. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2013 |
url |
https://doi.org/10.1371/journal.pntd.0002190 https://doaj.org/article/96e73b6f129d4965b203daf6b1dd0560 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 7, Iss 4, p e2190 (2013) |
op_relation |
http://europepmc.org/articles/PMC3636080?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0002190 https://doaj.org/article/96e73b6f129d4965b203daf6b1dd0560 |
op_doi |
https://doi.org/10.1371/journal.pntd.0002190 |
container_title |
PLoS Neglected Tropical Diseases |
container_volume |
7 |
container_issue |
4 |
container_start_page |
e2190 |
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1766344108188631040 |