Pre‐diagnostic levels of sVEGFR2, sTNFR2, sIL‐2Rα and sIL‐6R are associated with glioma risk: A nested case–control study of repeated samples
Abstract No strong aetiological factors have been established for glioma aside from genetic mutations and variants, ionising radiation and an inverse relationship with asthmas and allergies. Our aim was to investigate the association between pre‐diagnostic immune protein levels and glioma risk. We c...
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ftdoajarticles:oai:doaj.org/article:96b7b1bce85a4b789d8e6dbb8f515c86 2023-05-15T17:44:49+02:00 Pre‐diagnostic levels of sVEGFR2, sTNFR2, sIL‐2Rα and sIL‐6R are associated with glioma risk: A nested case–control study of repeated samples Wendy Yi‐Ying Wu Florentin Späth Carl Wibom Benny Björkblom Anna M. Dahlin Beatrice Melin 2022-02-01T00:00:00Z https://doi.org/10.1002/cam4.4505 https://doaj.org/article/96b7b1bce85a4b789d8e6dbb8f515c86 EN eng Wiley https://doi.org/10.1002/cam4.4505 https://doaj.org/toc/2045-7634 2045-7634 doi:10.1002/cam4.4505 https://doaj.org/article/96b7b1bce85a4b789d8e6dbb8f515c86 Cancer Medicine, Vol 11, Iss 4, Pp 1016-1025 (2022) a nested case–control study cytokines glioma aetiology Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 article 2022 ftdoajarticles https://doi.org/10.1002/cam4.4505 2022-12-31T16:32:17Z Abstract No strong aetiological factors have been established for glioma aside from genetic mutations and variants, ionising radiation and an inverse relationship with asthmas and allergies. Our aim was to investigate the association between pre‐diagnostic immune protein levels and glioma risk. We conducted a case–control study nested in the Northern Sweden Health and Disease Study cohort. We analysed 133 glioma cases and 133 control subjects matched by age, sex and date of blood donation. ELISA or Luminex bead‐based multiplex assays were used to measure plasma levels of 19 proteins. Conditional logistic regression models were used to estimate the odds ratios and 95% CIs. To further model the protein trajectories over time, the linear mixed‐effects models were conducted. We found that the levels of sVEGFR2, sTNFR2, sIL‐2Rα and sIL‐6R were associated with glioma risk. After adjusting for the time between blood sample collection and glioma diagnosis, the odds ratios were 1.72 (95% CI = 1.01–2.93), 1.48 (95% CI = 1.01–2.16) and 1.90 (95% CI = 1.14–3.17) for sTNFR2, sIL‐2Rα and sIL‐6R, respectively. The trajectory of sVEGFR2 concentrations over time was different between cases and controls (p‐value = 0.031), increasing for cases (0.8% per year) and constant for controls. Our findings suggest these proteins play important roles in gliomagenesis. Article in Journal/Newspaper Northern Sweden Directory of Open Access Journals: DOAJ Articles Cancer Medicine 11 4 1016 1025 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
a nested case–control study cytokines glioma aetiology Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 |
spellingShingle |
a nested case–control study cytokines glioma aetiology Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Wendy Yi‐Ying Wu Florentin Späth Carl Wibom Benny Björkblom Anna M. Dahlin Beatrice Melin Pre‐diagnostic levels of sVEGFR2, sTNFR2, sIL‐2Rα and sIL‐6R are associated with glioma risk: A nested case–control study of repeated samples |
topic_facet |
a nested case–control study cytokines glioma aetiology Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 |
description |
Abstract No strong aetiological factors have been established for glioma aside from genetic mutations and variants, ionising radiation and an inverse relationship with asthmas and allergies. Our aim was to investigate the association between pre‐diagnostic immune protein levels and glioma risk. We conducted a case–control study nested in the Northern Sweden Health and Disease Study cohort. We analysed 133 glioma cases and 133 control subjects matched by age, sex and date of blood donation. ELISA or Luminex bead‐based multiplex assays were used to measure plasma levels of 19 proteins. Conditional logistic regression models were used to estimate the odds ratios and 95% CIs. To further model the protein trajectories over time, the linear mixed‐effects models were conducted. We found that the levels of sVEGFR2, sTNFR2, sIL‐2Rα and sIL‐6R were associated with glioma risk. After adjusting for the time between blood sample collection and glioma diagnosis, the odds ratios were 1.72 (95% CI = 1.01–2.93), 1.48 (95% CI = 1.01–2.16) and 1.90 (95% CI = 1.14–3.17) for sTNFR2, sIL‐2Rα and sIL‐6R, respectively. The trajectory of sVEGFR2 concentrations over time was different between cases and controls (p‐value = 0.031), increasing for cases (0.8% per year) and constant for controls. Our findings suggest these proteins play important roles in gliomagenesis. |
format |
Article in Journal/Newspaper |
author |
Wendy Yi‐Ying Wu Florentin Späth Carl Wibom Benny Björkblom Anna M. Dahlin Beatrice Melin |
author_facet |
Wendy Yi‐Ying Wu Florentin Späth Carl Wibom Benny Björkblom Anna M. Dahlin Beatrice Melin |
author_sort |
Wendy Yi‐Ying Wu |
title |
Pre‐diagnostic levels of sVEGFR2, sTNFR2, sIL‐2Rα and sIL‐6R are associated with glioma risk: A nested case–control study of repeated samples |
title_short |
Pre‐diagnostic levels of sVEGFR2, sTNFR2, sIL‐2Rα and sIL‐6R are associated with glioma risk: A nested case–control study of repeated samples |
title_full |
Pre‐diagnostic levels of sVEGFR2, sTNFR2, sIL‐2Rα and sIL‐6R are associated with glioma risk: A nested case–control study of repeated samples |
title_fullStr |
Pre‐diagnostic levels of sVEGFR2, sTNFR2, sIL‐2Rα and sIL‐6R are associated with glioma risk: A nested case–control study of repeated samples |
title_full_unstemmed |
Pre‐diagnostic levels of sVEGFR2, sTNFR2, sIL‐2Rα and sIL‐6R are associated with glioma risk: A nested case–control study of repeated samples |
title_sort |
pre‐diagnostic levels of svegfr2, stnfr2, sil‐2rα and sil‐6r are associated with glioma risk: a nested case–control study of repeated samples |
publisher |
Wiley |
publishDate |
2022 |
url |
https://doi.org/10.1002/cam4.4505 https://doaj.org/article/96b7b1bce85a4b789d8e6dbb8f515c86 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_source |
Cancer Medicine, Vol 11, Iss 4, Pp 1016-1025 (2022) |
op_relation |
https://doi.org/10.1002/cam4.4505 https://doaj.org/toc/2045-7634 2045-7634 doi:10.1002/cam4.4505 https://doaj.org/article/96b7b1bce85a4b789d8e6dbb8f515c86 |
op_doi |
https://doi.org/10.1002/cam4.4505 |
container_title |
Cancer Medicine |
container_volume |
11 |
container_issue |
4 |
container_start_page |
1016 |
op_container_end_page |
1025 |
_version_ |
1766147115102240768 |