Praziquantel and risk of visual disorders: Case series assessment.
Introduction Praziquantel has been in use by helminthiasis and schistosomiasis control programs for about 30 years. Although deemed to be safe with regard to its adverse drug reaction profile in reference to the product information of Biltricide, the Eritrean Pharmacovigilance Center received report...
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ftdoajarticles:oai:doaj.org/article:96703200564d471585698b6c362ff692 2023-05-15T15:13:24+02:00 Praziquantel and risk of visual disorders: Case series assessment. Merhawi Debesai Mulugeta Russom 2020-04-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0008198 https://doaj.org/article/96703200564d471585698b6c362ff692 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0008198 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0008198 https://doaj.org/article/96703200564d471585698b6c362ff692 PLoS Neglected Tropical Diseases, Vol 14, Iss 4, p e0008198 (2020) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2020 ftdoajarticles https://doi.org/10.1371/journal.pntd.0008198 2022-12-31T07:16:57Z Introduction Praziquantel has been in use by helminthiasis and schistosomiasis control programs for about 30 years. Although deemed to be safe with regard to its adverse drug reaction profile in reference to the product information of Biltricide, the Eritrean Pharmacovigilance Center received reports of visual abnormalities related to the drug. This is a case series assessment of unusual cases of visual abnormalities associated with praziquantel. Methods Search was made in VigiBase by setting praziquantel as a drug substance, Eritrea as the reporting country and all eye disorders, high level term (HLT) to capture all visual disorders associated with Praziquantel. The retrieved dataset was exported into an Excel spreadsheet for descriptive analysis and causality was assessed using Austin Bradford-Hill criteria. Results There are a total of 2579 Individual Case Safety Reports (ICSRs) of various Adverse Drug Reactions (ADRs) of praziquantel reported from Eritrea in VigiBase. The 61 reports of visual abnormalities that arose within the first 24 hours of praziquantel administration are of note. With a strong association as evidenced by the positive IC025 value, the association of praziquantel and blurred vision was consistently reported from different health facilities over a period of three years. It is a specific association in terms of both the exposure (only praziquantel) and the outcome (blurred vision) as reported in majority of the cases. However, experimental evidences for the association are lacking, the underweight profile of the Eritrean population suggests overdosing as a possible risk factor for the occurrence of these reactions. Conclusion The strength, temporal plausibility, consistency and specificity of the association are suggestive of a causal association between praziquantel and visual disorders. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Austin PLOS Neglected Tropical Diseases 14 4 e0008198 |
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Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
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English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Merhawi Debesai Mulugeta Russom Praziquantel and risk of visual disorders: Case series assessment. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Introduction Praziquantel has been in use by helminthiasis and schistosomiasis control programs for about 30 years. Although deemed to be safe with regard to its adverse drug reaction profile in reference to the product information of Biltricide, the Eritrean Pharmacovigilance Center received reports of visual abnormalities related to the drug. This is a case series assessment of unusual cases of visual abnormalities associated with praziquantel. Methods Search was made in VigiBase by setting praziquantel as a drug substance, Eritrea as the reporting country and all eye disorders, high level term (HLT) to capture all visual disorders associated with Praziquantel. The retrieved dataset was exported into an Excel spreadsheet for descriptive analysis and causality was assessed using Austin Bradford-Hill criteria. Results There are a total of 2579 Individual Case Safety Reports (ICSRs) of various Adverse Drug Reactions (ADRs) of praziquantel reported from Eritrea in VigiBase. The 61 reports of visual abnormalities that arose within the first 24 hours of praziquantel administration are of note. With a strong association as evidenced by the positive IC025 value, the association of praziquantel and blurred vision was consistently reported from different health facilities over a period of three years. It is a specific association in terms of both the exposure (only praziquantel) and the outcome (blurred vision) as reported in majority of the cases. However, experimental evidences for the association are lacking, the underweight profile of the Eritrean population suggests overdosing as a possible risk factor for the occurrence of these reactions. Conclusion The strength, temporal plausibility, consistency and specificity of the association are suggestive of a causal association between praziquantel and visual disorders. |
format |
Article in Journal/Newspaper |
author |
Merhawi Debesai Mulugeta Russom |
author_facet |
Merhawi Debesai Mulugeta Russom |
author_sort |
Merhawi Debesai |
title |
Praziquantel and risk of visual disorders: Case series assessment. |
title_short |
Praziquantel and risk of visual disorders: Case series assessment. |
title_full |
Praziquantel and risk of visual disorders: Case series assessment. |
title_fullStr |
Praziquantel and risk of visual disorders: Case series assessment. |
title_full_unstemmed |
Praziquantel and risk of visual disorders: Case series assessment. |
title_sort |
praziquantel and risk of visual disorders: case series assessment. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2020 |
url |
https://doi.org/10.1371/journal.pntd.0008198 https://doaj.org/article/96703200564d471585698b6c362ff692 |
geographic |
Arctic Austin |
geographic_facet |
Arctic Austin |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 14, Iss 4, p e0008198 (2020) |
op_relation |
https://doi.org/10.1371/journal.pntd.0008198 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0008198 https://doaj.org/article/96703200564d471585698b6c362ff692 |
op_doi |
https://doi.org/10.1371/journal.pntd.0008198 |
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PLOS Neglected Tropical Diseases |
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14 |
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4 |
container_start_page |
e0008198 |
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