HTLV- I infection is not associated with a higher risk of death in peruvian HIV-infected patients A infecção pelo HTLV- I não está associada a maior risco de morte em pacientes peruanos infectados pelo HIV
Limited and contradictory information exists regarding the prognosis of HIV/HTLV-I co-infection. Our goal was to estimate the effect of HTLV-I infection on mortality in HIV-infected patients at a HIV reference center in Peru. We studied a retrospective cohort of HIV-infected patients, who were expos...
Published in: | Revista do Instituto de Medicina Tropical de São Paulo |
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ftdoajarticles:oai:doaj.org/article:966af6f29233415d81d7c7b4ea218dbd 2024-09-09T19:28:39+00:00 HTLV- I infection is not associated with a higher risk of death in peruvian HIV-infected patients A infecção pelo HTLV- I não está associada a maior risco de morte em pacientes peruanos infectados pelo HIV Jaime A. Collins Adrián V. Hernández José A. Hidalgo Raúl Salazar 2009-08-01T00:00:00Z https://doi.org/10.1590/S0036-46652009000400004 https://doaj.org/article/966af6f29233415d81d7c7b4ea218dbd EN eng Universidade de São Paulo (USP) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652009000400004 https://doaj.org/toc/0036-4665 https://doaj.org/toc/1678-9946 doi:10.1590/S0036-46652009000400004 0036-4665 1678-9946 https://doaj.org/article/966af6f29233415d81d7c7b4ea218dbd Revista do Instituto de Medicina Tropical de São Paulo, Vol 51, Iss 4, Pp 197-201 (2009) HIV/HTLV-I co-infection Death Peru Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2009 ftdoajarticles https://doi.org/10.1590/S0036-46652009000400004 2024-08-05T17:49:30Z Limited and contradictory information exists regarding the prognosis of HIV/HTLV-I co-infection. Our goal was to estimate the effect of HTLV-I infection on mortality in HIV-infected patients at a HIV reference center in Peru. We studied a retrospective cohort of HIV-infected patients, who were exposed or unexposed to HTLV-I. Exposed patients were Western Blot (WB) positive for both retroviruses. Unexposed patients were WB positive for HIV, and had least one negative EIA for HTLV-I. These were selected among patients who entered our Program immediately before and after each exposed patient, between January 1990 and June 2004. Survival time was considered between the diagnosis of exposure to HTLV-I and death or censoring. Confounding variables were age, gender, baseline HIV clinical stage, baseline CD4+ T cell count, and antiretroviral therapy. We studied 50 exposed, and 100 unexposed patients. Exposed patients had a shorter survival compared to unexposed patients [median survival: 47 months (95% CI: 17-77) vs. 85 months (95% CI: 70-100), unadjusted p = 0.06]. Exposed patients had a higher rate of mortality compared to unexposed patients (HIV/HTLV-I (24/50 [48%]) vs. HIV only (37/100 [37%]), univariable p = 0.2]. HTLV-I exposure was not associated to a higher risk of death in the adjusted analysis: HR: 1.2 (0.4-3.5). AIDS clinical stage and lack of antiretroviral therapy were associated to a higher risk of dying. In conclusions, HTLV-I infection was not associated with a higher risk of death in Peruvian HIV-infected patients. Advanced HIV infection and lack of antiretroviral therapy may explain the excess of mortality in this population. Existe informação limitada e contraditória sobre o prognóstico da co-infecção pelo Vírus da Imunodeficiência Humana Tipo 1 (HIV-1) e Vírus Linfotrópico de Células T Humanas Tipo I (HTLV-I). Nosso objetivo foi estimar o efeito da infecção pelo HTLV-I na mortalidade de pacientes infectados pelo HIV-1 em Centro de Referência de HIV no Peru. Trata-se de uma coorte retrospectiva de ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Eia ENVELOPE(7.755,7.755,63.024,63.024) Revista do Instituto de Medicina Tropical de São Paulo 51 4 197 201 |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
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language |
English |
topic |
HIV/HTLV-I co-infection Death Peru Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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HIV/HTLV-I co-infection Death Peru Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Jaime A. Collins Adrián V. Hernández José A. Hidalgo Raúl Salazar HTLV- I infection is not associated with a higher risk of death in peruvian HIV-infected patients A infecção pelo HTLV- I não está associada a maior risco de morte em pacientes peruanos infectados pelo HIV |
topic_facet |
HIV/HTLV-I co-infection Death Peru Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Limited and contradictory information exists regarding the prognosis of HIV/HTLV-I co-infection. Our goal was to estimate the effect of HTLV-I infection on mortality in HIV-infected patients at a HIV reference center in Peru. We studied a retrospective cohort of HIV-infected patients, who were exposed or unexposed to HTLV-I. Exposed patients were Western Blot (WB) positive for both retroviruses. Unexposed patients were WB positive for HIV, and had least one negative EIA for HTLV-I. These were selected among patients who entered our Program immediately before and after each exposed patient, between January 1990 and June 2004. Survival time was considered between the diagnosis of exposure to HTLV-I and death or censoring. Confounding variables were age, gender, baseline HIV clinical stage, baseline CD4+ T cell count, and antiretroviral therapy. We studied 50 exposed, and 100 unexposed patients. Exposed patients had a shorter survival compared to unexposed patients [median survival: 47 months (95% CI: 17-77) vs. 85 months (95% CI: 70-100), unadjusted p = 0.06]. Exposed patients had a higher rate of mortality compared to unexposed patients (HIV/HTLV-I (24/50 [48%]) vs. HIV only (37/100 [37%]), univariable p = 0.2]. HTLV-I exposure was not associated to a higher risk of death in the adjusted analysis: HR: 1.2 (0.4-3.5). AIDS clinical stage and lack of antiretroviral therapy were associated to a higher risk of dying. In conclusions, HTLV-I infection was not associated with a higher risk of death in Peruvian HIV-infected patients. Advanced HIV infection and lack of antiretroviral therapy may explain the excess of mortality in this population. Existe informação limitada e contraditória sobre o prognóstico da co-infecção pelo Vírus da Imunodeficiência Humana Tipo 1 (HIV-1) e Vírus Linfotrópico de Células T Humanas Tipo I (HTLV-I). Nosso objetivo foi estimar o efeito da infecção pelo HTLV-I na mortalidade de pacientes infectados pelo HIV-1 em Centro de Referência de HIV no Peru. Trata-se de uma coorte retrospectiva de ... |
format |
Article in Journal/Newspaper |
author |
Jaime A. Collins Adrián V. Hernández José A. Hidalgo Raúl Salazar |
author_facet |
Jaime A. Collins Adrián V. Hernández José A. Hidalgo Raúl Salazar |
author_sort |
Jaime A. Collins |
title |
HTLV- I infection is not associated with a higher risk of death in peruvian HIV-infected patients A infecção pelo HTLV- I não está associada a maior risco de morte em pacientes peruanos infectados pelo HIV |
title_short |
HTLV- I infection is not associated with a higher risk of death in peruvian HIV-infected patients A infecção pelo HTLV- I não está associada a maior risco de morte em pacientes peruanos infectados pelo HIV |
title_full |
HTLV- I infection is not associated with a higher risk of death in peruvian HIV-infected patients A infecção pelo HTLV- I não está associada a maior risco de morte em pacientes peruanos infectados pelo HIV |
title_fullStr |
HTLV- I infection is not associated with a higher risk of death in peruvian HIV-infected patients A infecção pelo HTLV- I não está associada a maior risco de morte em pacientes peruanos infectados pelo HIV |
title_full_unstemmed |
HTLV- I infection is not associated with a higher risk of death in peruvian HIV-infected patients A infecção pelo HTLV- I não está associada a maior risco de morte em pacientes peruanos infectados pelo HIV |
title_sort |
htlv- i infection is not associated with a higher risk of death in peruvian hiv-infected patients a infecção pelo htlv- i não está associada a maior risco de morte em pacientes peruanos infectados pelo hiv |
publisher |
Universidade de São Paulo (USP) |
publishDate |
2009 |
url |
https://doi.org/10.1590/S0036-46652009000400004 https://doaj.org/article/966af6f29233415d81d7c7b4ea218dbd |
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ENVELOPE(7.755,7.755,63.024,63.024) |
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Arctic Eia |
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Arctic Eia |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista do Instituto de Medicina Tropical de São Paulo, Vol 51, Iss 4, Pp 197-201 (2009) |
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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652009000400004 https://doaj.org/toc/0036-4665 https://doaj.org/toc/1678-9946 doi:10.1590/S0036-46652009000400004 0036-4665 1678-9946 https://doaj.org/article/966af6f29233415d81d7c7b4ea218dbd |
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https://doi.org/10.1590/S0036-46652009000400004 |
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