Cellular and Humoral Immune Responses after Immunisation with Low Virulent African Swine Fever Virus in the Large White Inbred Babraham Line and Outbred Domestic Pigs
African swine fever virus is currently present in all of the world’s continents apart from Antarctica, and efforts to control the disease are hampered by the lack of a commercially available vaccine. The Babraham large white pig is a highly inbred line that could represent a powerful tool to improve...
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ftdoajarticles:oai:doaj.org/article:9630f48aaa974eee8b483ade0038b462 2023-05-15T13:37:33+02:00 Cellular and Humoral Immune Responses after Immunisation with Low Virulent African Swine Fever Virus in the Large White Inbred Babraham Line and Outbred Domestic Pigs Lynnette C. Goatley Rachel H. Nash Catherine Andrews Zoe Hargreaves Priscilla Tng Ana Luisa Reis Simon P. Graham Christopher L. Netherton 2022-07-01T00:00:00Z https://doi.org/10.3390/v14071487 https://doaj.org/article/9630f48aaa974eee8b483ade0038b462 EN eng MDPI AG https://www.mdpi.com/1999-4915/14/7/1487 https://doaj.org/toc/1999-4915 doi:10.3390/v14071487 1999-4915 https://doaj.org/article/9630f48aaa974eee8b483ade0038b462 Viruses, Vol 14, Iss 1487, p 1487 (2022) african swine fever virus immune response antibody cell-mediated immunity T-cell response inbred pigs Microbiology QR1-502 article 2022 ftdoajarticles https://doi.org/10.3390/v14071487 2022-12-30T22:43:51Z African swine fever virus is currently present in all of the world’s continents apart from Antarctica, and efforts to control the disease are hampered by the lack of a commercially available vaccine. The Babraham large white pig is a highly inbred line that could represent a powerful tool to improve our understanding of the protective immune responses to this complex pathogen; however, previous studies indicated differential vaccine responses after the African swine fever virus challenge of inbred minipigs with different swine leukocyte antigen haplotypes. Lymphocyte numbers and African swine fever virus-specific antibody and T-cell responses were measured in inbred and outbred animals after inoculation with a low virulent African swine fever virus isolate and subsequent challenge with a related virulent virus. Surprisingly, diminished immune responses were observed in the Babraham pigs when compared to the outbred animals, and the inbred pigs were not protected after challenge. Recovery of Babraham pigs after challenge weakly correlated with antibody responses, whereas protective responses in outbred animals more closely correlated with the T-cell response. The Babraham pig may, therefore, represent a useful model for studying the role of antibodies in protection against the African swine fever virus. Article in Journal/Newspaper Antarc* Antarctica Directory of Open Access Journals: DOAJ Articles Viruses 14 7 1487 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
african swine fever virus immune response antibody cell-mediated immunity T-cell response inbred pigs Microbiology QR1-502 |
spellingShingle |
african swine fever virus immune response antibody cell-mediated immunity T-cell response inbred pigs Microbiology QR1-502 Lynnette C. Goatley Rachel H. Nash Catherine Andrews Zoe Hargreaves Priscilla Tng Ana Luisa Reis Simon P. Graham Christopher L. Netherton Cellular and Humoral Immune Responses after Immunisation with Low Virulent African Swine Fever Virus in the Large White Inbred Babraham Line and Outbred Domestic Pigs |
topic_facet |
african swine fever virus immune response antibody cell-mediated immunity T-cell response inbred pigs Microbiology QR1-502 |
description |
African swine fever virus is currently present in all of the world’s continents apart from Antarctica, and efforts to control the disease are hampered by the lack of a commercially available vaccine. The Babraham large white pig is a highly inbred line that could represent a powerful tool to improve our understanding of the protective immune responses to this complex pathogen; however, previous studies indicated differential vaccine responses after the African swine fever virus challenge of inbred minipigs with different swine leukocyte antigen haplotypes. Lymphocyte numbers and African swine fever virus-specific antibody and T-cell responses were measured in inbred and outbred animals after inoculation with a low virulent African swine fever virus isolate and subsequent challenge with a related virulent virus. Surprisingly, diminished immune responses were observed in the Babraham pigs when compared to the outbred animals, and the inbred pigs were not protected after challenge. Recovery of Babraham pigs after challenge weakly correlated with antibody responses, whereas protective responses in outbred animals more closely correlated with the T-cell response. The Babraham pig may, therefore, represent a useful model for studying the role of antibodies in protection against the African swine fever virus. |
format |
Article in Journal/Newspaper |
author |
Lynnette C. Goatley Rachel H. Nash Catherine Andrews Zoe Hargreaves Priscilla Tng Ana Luisa Reis Simon P. Graham Christopher L. Netherton |
author_facet |
Lynnette C. Goatley Rachel H. Nash Catherine Andrews Zoe Hargreaves Priscilla Tng Ana Luisa Reis Simon P. Graham Christopher L. Netherton |
author_sort |
Lynnette C. Goatley |
title |
Cellular and Humoral Immune Responses after Immunisation with Low Virulent African Swine Fever Virus in the Large White Inbred Babraham Line and Outbred Domestic Pigs |
title_short |
Cellular and Humoral Immune Responses after Immunisation with Low Virulent African Swine Fever Virus in the Large White Inbred Babraham Line and Outbred Domestic Pigs |
title_full |
Cellular and Humoral Immune Responses after Immunisation with Low Virulent African Swine Fever Virus in the Large White Inbred Babraham Line and Outbred Domestic Pigs |
title_fullStr |
Cellular and Humoral Immune Responses after Immunisation with Low Virulent African Swine Fever Virus in the Large White Inbred Babraham Line and Outbred Domestic Pigs |
title_full_unstemmed |
Cellular and Humoral Immune Responses after Immunisation with Low Virulent African Swine Fever Virus in the Large White Inbred Babraham Line and Outbred Domestic Pigs |
title_sort |
cellular and humoral immune responses after immunisation with low virulent african swine fever virus in the large white inbred babraham line and outbred domestic pigs |
publisher |
MDPI AG |
publishDate |
2022 |
url |
https://doi.org/10.3390/v14071487 https://doaj.org/article/9630f48aaa974eee8b483ade0038b462 |
genre |
Antarc* Antarctica |
genre_facet |
Antarc* Antarctica |
op_source |
Viruses, Vol 14, Iss 1487, p 1487 (2022) |
op_relation |
https://www.mdpi.com/1999-4915/14/7/1487 https://doaj.org/toc/1999-4915 doi:10.3390/v14071487 1999-4915 https://doaj.org/article/9630f48aaa974eee8b483ade0038b462 |
op_doi |
https://doi.org/10.3390/v14071487 |
container_title |
Viruses |
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14 |
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7 |
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1487 |
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1766093867836243968 |