Cynodon dactylon extract ameliorates cognitive functions and cerebellar oxidative stress in whole body irradiated mice
Objective: To explore the effect of hydroalcoholic extract of Cynodon dactylon on the whole body radiation-induced oxidative status of the cerebellum and cognitive impairments in mice. Methods: Swiss albino mice were randomly divided into the control group, radiation control group, low dose and high...
Published in: | Asian Pacific Journal of Tropical Biomedicine |
---|---|
Main Authors: | , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Wolters Kluwer Medknow Publications
2019
|
Subjects: | |
Online Access: | https://doi.org/10.4103/2221-1691.261763 https://doaj.org/article/962332197f36418495ed0d0f532a255a |
id |
ftdoajarticles:oai:doaj.org/article:962332197f36418495ed0d0f532a255a |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:962332197f36418495ed0d0f532a255a 2023-05-15T15:09:44+02:00 Cynodon dactylon extract ameliorates cognitive functions and cerebellar oxidative stress in whole body irradiated mice Roopesh Poojary Nayanatara Arun Kumar Reshma Kumarchandra N A Vinodini K Bhagyalakshmi Ganesh Sanjeev 2019-01-01T00:00:00Z https://doi.org/10.4103/2221-1691.261763 https://doaj.org/article/962332197f36418495ed0d0f532a255a EN eng Wolters Kluwer Medknow Publications http://www.apjtb.org/article.asp?issn=2221-1691;year=2019;volume=9;issue=7;spage=278;epage=283;aulast=Poojary https://doaj.org/toc/2221-1691 2221-1691 doi:10.4103/2221-1691.261763 https://doaj.org/article/962332197f36418495ed0d0f532a255a Asian Pacific Journal of Tropical Biomedicine, Vol 9, Iss 7, Pp 278-283 (2019) cerebellum radiation cognition cynodon dactylon memory Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 article 2019 ftdoajarticles https://doi.org/10.4103/2221-1691.261763 2022-12-31T01:16:51Z Objective: To explore the effect of hydroalcoholic extract of Cynodon dactylon on the whole body radiation-induced oxidative status of the cerebellum and cognitive impairments in mice. Methods: Swiss albino mice were randomly divided into the control group, radiation control group, low dose and high dose Cynodon dactylon extract treated groups and pre-treated with Cynodon dactylon extract before irradiation. Cynodon dactylon extract was administered for 7 d daily in low dose (0.25 g/kg) and high dose (1 g/kg). On day 7, mice were irradiated with a sublethal dose of 5 Gy gamma rays. Motor coordination was assessed by elevated rotarod test and spatial memory was studied by water maze test. Subsequently, biochemical markers (glutathione, lipid peroxidation and nitric oxide levels) in the cerebellum were evaluated. Results: The gamma irradiated group showed significant impairment in motor coordination and spatial memory compared to normal mice. Mice treated by Cynodon dactylon extract prior to gamma radiation showed good improvement in both paradigms compared to the radiation control group. Moreover, glutathione level was increased, while lipid peroxidation and nitric oxide levels were significantly reduced in mice receiving low dose and high dose of Cynodon dactylon extract compared to the radiation control group. Conclusions: The present study suggests the neuroprotective role of Cynodon dactylon against radiation-induced cognitive impairment and oxidative stress on the cerebellum of mice. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Biomedicine 9 7 278 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
cerebellum radiation cognition cynodon dactylon memory Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
spellingShingle |
cerebellum radiation cognition cynodon dactylon memory Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 Roopesh Poojary Nayanatara Arun Kumar Reshma Kumarchandra N A Vinodini K Bhagyalakshmi Ganesh Sanjeev Cynodon dactylon extract ameliorates cognitive functions and cerebellar oxidative stress in whole body irradiated mice |
topic_facet |
cerebellum radiation cognition cynodon dactylon memory Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
description |
Objective: To explore the effect of hydroalcoholic extract of Cynodon dactylon on the whole body radiation-induced oxidative status of the cerebellum and cognitive impairments in mice. Methods: Swiss albino mice were randomly divided into the control group, radiation control group, low dose and high dose Cynodon dactylon extract treated groups and pre-treated with Cynodon dactylon extract before irradiation. Cynodon dactylon extract was administered for 7 d daily in low dose (0.25 g/kg) and high dose (1 g/kg). On day 7, mice were irradiated with a sublethal dose of 5 Gy gamma rays. Motor coordination was assessed by elevated rotarod test and spatial memory was studied by water maze test. Subsequently, biochemical markers (glutathione, lipid peroxidation and nitric oxide levels) in the cerebellum were evaluated. Results: The gamma irradiated group showed significant impairment in motor coordination and spatial memory compared to normal mice. Mice treated by Cynodon dactylon extract prior to gamma radiation showed good improvement in both paradigms compared to the radiation control group. Moreover, glutathione level was increased, while lipid peroxidation and nitric oxide levels were significantly reduced in mice receiving low dose and high dose of Cynodon dactylon extract compared to the radiation control group. Conclusions: The present study suggests the neuroprotective role of Cynodon dactylon against radiation-induced cognitive impairment and oxidative stress on the cerebellum of mice. |
format |
Article in Journal/Newspaper |
author |
Roopesh Poojary Nayanatara Arun Kumar Reshma Kumarchandra N A Vinodini K Bhagyalakshmi Ganesh Sanjeev |
author_facet |
Roopesh Poojary Nayanatara Arun Kumar Reshma Kumarchandra N A Vinodini K Bhagyalakshmi Ganesh Sanjeev |
author_sort |
Roopesh Poojary |
title |
Cynodon dactylon extract ameliorates cognitive functions and cerebellar oxidative stress in whole body irradiated mice |
title_short |
Cynodon dactylon extract ameliorates cognitive functions and cerebellar oxidative stress in whole body irradiated mice |
title_full |
Cynodon dactylon extract ameliorates cognitive functions and cerebellar oxidative stress in whole body irradiated mice |
title_fullStr |
Cynodon dactylon extract ameliorates cognitive functions and cerebellar oxidative stress in whole body irradiated mice |
title_full_unstemmed |
Cynodon dactylon extract ameliorates cognitive functions and cerebellar oxidative stress in whole body irradiated mice |
title_sort |
cynodon dactylon extract ameliorates cognitive functions and cerebellar oxidative stress in whole body irradiated mice |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2019 |
url |
https://doi.org/10.4103/2221-1691.261763 https://doaj.org/article/962332197f36418495ed0d0f532a255a |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Biomedicine, Vol 9, Iss 7, Pp 278-283 (2019) |
op_relation |
http://www.apjtb.org/article.asp?issn=2221-1691;year=2019;volume=9;issue=7;spage=278;epage=283;aulast=Poojary https://doaj.org/toc/2221-1691 2221-1691 doi:10.4103/2221-1691.261763 https://doaj.org/article/962332197f36418495ed0d0f532a255a |
op_doi |
https://doi.org/10.4103/2221-1691.261763 |
container_title |
Asian Pacific Journal of Tropical Biomedicine |
container_volume |
9 |
container_issue |
7 |
container_start_page |
278 |
_version_ |
1766340858264682496 |