High CO2 and silicate limitation synergistically increase the toxicity of Pseudo-nitzschia fraudulenta.
Anthropogenic CO(2) is progressively acidifying the ocean, but the responses of harmful algal bloom species that produce toxins that can bioaccumulate remain virtually unknown. The neurotoxin domoic acid is produced by the globally-distributed diatom genus Pseudo-nitzschia. This toxin is responsible...
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ftdoajarticles:oai:doaj.org/article:961d2187b04b4c359af3850ef7dc0af9 2023-05-15T17:51:30+02:00 High CO2 and silicate limitation synergistically increase the toxicity of Pseudo-nitzschia fraudulenta. Avery O Tatters Fei-Xue Fu David A Hutchins 2012-01-01T00:00:00Z https://doi.org/10.1371/journal.pone.0032116 https://doaj.org/article/961d2187b04b4c359af3850ef7dc0af9 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC3283721?pdf=render https://doaj.org/toc/1932-6203 1932-6203 doi:10.1371/journal.pone.0032116 https://doaj.org/article/961d2187b04b4c359af3850ef7dc0af9 PLoS ONE, Vol 7, Iss 2, p e32116 (2012) Medicine R Science Q article 2012 ftdoajarticles https://doi.org/10.1371/journal.pone.0032116 2022-12-31T08:21:06Z Anthropogenic CO(2) is progressively acidifying the ocean, but the responses of harmful algal bloom species that produce toxins that can bioaccumulate remain virtually unknown. The neurotoxin domoic acid is produced by the globally-distributed diatom genus Pseudo-nitzschia. This toxin is responsible for amnesic shellfish poisoning, which can result in illness or death in humans and regularly causes mass mortalities of marine mammals and birds. Domoic acid production by Pseudo-nitzschia cells is known to be regulated by nutrient availability, but potential interactions with increasing seawater CO(2) concentrations are poorly understood. Here we present experiments measuring domoic acid production by acclimatized cultures of Pseudo-nitzschia fraudulenta that demonstrate a strong synergism between projected future CO(2) levels (765 ppm) and silicate-limited growth, which greatly increases cellular toxicity relative to growth under modern atmospheric (360 ppm) or pre-industrial (200 ppm) CO(2) conditions. Cellular Si:C ratios decrease with increasing CO(2), in a trend opposite to that seen for domoic acid production. The coastal California upwelling system where this species was isolated currently exhibits rapidly increasing levels of anthropogenic acidification, as well as widespread episodic silicate limitation of diatom growth. Our results suggest that the current ecosystem and human health impacts of toxic Pseudo-nitzschia blooms could be greatly exacerbated by future ocean acidification and 'carbon fertilization' of the coastal ocean. Article in Journal/Newspaper Ocean acidification Directory of Open Access Journals: DOAJ Articles PLoS ONE 7 2 e32116 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
topic |
Medicine R Science Q |
spellingShingle |
Medicine R Science Q Avery O Tatters Fei-Xue Fu David A Hutchins High CO2 and silicate limitation synergistically increase the toxicity of Pseudo-nitzschia fraudulenta. |
topic_facet |
Medicine R Science Q |
description |
Anthropogenic CO(2) is progressively acidifying the ocean, but the responses of harmful algal bloom species that produce toxins that can bioaccumulate remain virtually unknown. The neurotoxin domoic acid is produced by the globally-distributed diatom genus Pseudo-nitzschia. This toxin is responsible for amnesic shellfish poisoning, which can result in illness or death in humans and regularly causes mass mortalities of marine mammals and birds. Domoic acid production by Pseudo-nitzschia cells is known to be regulated by nutrient availability, but potential interactions with increasing seawater CO(2) concentrations are poorly understood. Here we present experiments measuring domoic acid production by acclimatized cultures of Pseudo-nitzschia fraudulenta that demonstrate a strong synergism between projected future CO(2) levels (765 ppm) and silicate-limited growth, which greatly increases cellular toxicity relative to growth under modern atmospheric (360 ppm) or pre-industrial (200 ppm) CO(2) conditions. Cellular Si:C ratios decrease with increasing CO(2), in a trend opposite to that seen for domoic acid production. The coastal California upwelling system where this species was isolated currently exhibits rapidly increasing levels of anthropogenic acidification, as well as widespread episodic silicate limitation of diatom growth. Our results suggest that the current ecosystem and human health impacts of toxic Pseudo-nitzschia blooms could be greatly exacerbated by future ocean acidification and 'carbon fertilization' of the coastal ocean. |
format |
Article in Journal/Newspaper |
author |
Avery O Tatters Fei-Xue Fu David A Hutchins |
author_facet |
Avery O Tatters Fei-Xue Fu David A Hutchins |
author_sort |
Avery O Tatters |
title |
High CO2 and silicate limitation synergistically increase the toxicity of Pseudo-nitzschia fraudulenta. |
title_short |
High CO2 and silicate limitation synergistically increase the toxicity of Pseudo-nitzschia fraudulenta. |
title_full |
High CO2 and silicate limitation synergistically increase the toxicity of Pseudo-nitzschia fraudulenta. |
title_fullStr |
High CO2 and silicate limitation synergistically increase the toxicity of Pseudo-nitzschia fraudulenta. |
title_full_unstemmed |
High CO2 and silicate limitation synergistically increase the toxicity of Pseudo-nitzschia fraudulenta. |
title_sort |
high co2 and silicate limitation synergistically increase the toxicity of pseudo-nitzschia fraudulenta. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2012 |
url |
https://doi.org/10.1371/journal.pone.0032116 https://doaj.org/article/961d2187b04b4c359af3850ef7dc0af9 |
genre |
Ocean acidification |
genre_facet |
Ocean acidification |
op_source |
PLoS ONE, Vol 7, Iss 2, p e32116 (2012) |
op_relation |
http://europepmc.org/articles/PMC3283721?pdf=render https://doaj.org/toc/1932-6203 1932-6203 doi:10.1371/journal.pone.0032116 https://doaj.org/article/961d2187b04b4c359af3850ef7dc0af9 |
op_doi |
https://doi.org/10.1371/journal.pone.0032116 |
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PLoS ONE |
container_volume |
7 |
container_issue |
2 |
container_start_page |
e32116 |
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