Single nucleotide polymorphisms in the β-tubulin gene family of Ascaris lumbricoides and their potential role in benzimidazole resistance: a systematic review

• Published in: Frontiers in Tropical Diseases
• Main Authors: Teniel Ramkhelawan, Pragalathan Naidoo, Zilungile L. Mkhize-Kwitshana
• Format: Article in Journal/Newspaper
• Language: English
• Published: Frontiers Media S.A. 2024
• Subjects: Ascaris lumbricoides; β-tubulin gene polymorphisms; benzimidazole drug resistance; Mebendazole and Albendazole; treatment efficacy; Arctic medicine. Tropical medicine; RC955-962; Arctic; Tac
• Online Access: https://doi.org/10.3389/fitd.2023.1303873; https://doaj.org/article/96199a88e02d43a198f1773c2ff3373e

IntroductionThe most common soil-transmitted helminthic infection is caused by Ascaris lumbricoides (A. lumbricoides). Approximately 4 billion people are at risk of infection globally. The World Health Organisation recommends the administration of benzimidazole- containing deworming drugs (Albendazo...