Use of pyriproxyfen in control of Aedes mosquitoes: A systematic review.
Dengue is the most rapidly spreading arboviral disease in the world. The current lack of fully protective vaccines and clinical therapeutics creates an urgent need to identify more effective means of controlling Aedes mosquitos, principally Aedes aegypti, as the main vector of dengue. Pyriproxyfen (...
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ftdoajarticles:oai:doaj.org/article:960e8312c4594cdfb10f71f7dad037e7 2023-05-15T15:16:26+02:00 Use of pyriproxyfen in control of Aedes mosquitoes: A systematic review. John Christian Hustedt Ross Boyce John Bradley Jeffrey Hii Neal Alexander 2020-06-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0008205 https://doaj.org/article/960e8312c4594cdfb10f71f7dad037e7 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0008205 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0008205 https://doaj.org/article/960e8312c4594cdfb10f71f7dad037e7 PLoS Neglected Tropical Diseases, Vol 14, Iss 6, p e0008205 (2020) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2020 ftdoajarticles https://doi.org/10.1371/journal.pntd.0008205 2022-12-31T06:00:46Z Dengue is the most rapidly spreading arboviral disease in the world. The current lack of fully protective vaccines and clinical therapeutics creates an urgent need to identify more effective means of controlling Aedes mosquitos, principally Aedes aegypti, as the main vector of dengue. Pyriproxyfen (PPF) is an increasingly used hormone analogue that prevents juvenile Aedes mosquitoes from becoming adults and being incapable of transmitting dengue. The objectives of the review were to (1) Determine the effect of PPF on endpoints including percentage inhibition of emergence to adulthood, larval mortality, and resistance ratios; and (2) Determine the different uses, strengths, and limitations of PPF in control of Aedes. A systematic search was applied to Pubmed, EMBASE, Web of Science, LILACS, Global Health, and the Cochrane database of Systematic Reviews. Out of 1,369 records, 90 studies met the inclusion criteria. Nearly all fit in one of the following four categories 1) Efficacy of granules, 2) Auto-dissemination/horizontal transfer, 3) use of ultra-low volume thermal fogging (ULV), thermal fogging (TF), or fumigant technologies, and 4) assessing mosquito resistance. PPF granules had consistently efficacious results of 90-100% inhibition of emergence for up to 90 days. The evidence is less robust but promising regarding PPF dust for auto-dissemination and the use of PPF in ULV, TF and fumigants. Several studies also found that while mosquito populations were still susceptible to PPF, the lethal concentrations increased among temephos-resistant mosquitoes compared to reference strains. The evidence is strong that PPF does increase immature mortality and adult inhibition in settings represented in the included studies, however future research should focus on areas where there is less evidence (e.g. auto-dissemination, sprays) and new use cases for PPF. A better understanding of the biological mechanisms of cross-resistance between PPF, temephos, and other insecticides will allow control programs to make better ... Article in Journal/Newspaper Arctic ulv Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 14 6 e0008205 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 John Christian Hustedt Ross Boyce John Bradley Jeffrey Hii Neal Alexander Use of pyriproxyfen in control of Aedes mosquitoes: A systematic review. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Dengue is the most rapidly spreading arboviral disease in the world. The current lack of fully protective vaccines and clinical therapeutics creates an urgent need to identify more effective means of controlling Aedes mosquitos, principally Aedes aegypti, as the main vector of dengue. Pyriproxyfen (PPF) is an increasingly used hormone analogue that prevents juvenile Aedes mosquitoes from becoming adults and being incapable of transmitting dengue. The objectives of the review were to (1) Determine the effect of PPF on endpoints including percentage inhibition of emergence to adulthood, larval mortality, and resistance ratios; and (2) Determine the different uses, strengths, and limitations of PPF in control of Aedes. A systematic search was applied to Pubmed, EMBASE, Web of Science, LILACS, Global Health, and the Cochrane database of Systematic Reviews. Out of 1,369 records, 90 studies met the inclusion criteria. Nearly all fit in one of the following four categories 1) Efficacy of granules, 2) Auto-dissemination/horizontal transfer, 3) use of ultra-low volume thermal fogging (ULV), thermal fogging (TF), or fumigant technologies, and 4) assessing mosquito resistance. PPF granules had consistently efficacious results of 90-100% inhibition of emergence for up to 90 days. The evidence is less robust but promising regarding PPF dust for auto-dissemination and the use of PPF in ULV, TF and fumigants. Several studies also found that while mosquito populations were still susceptible to PPF, the lethal concentrations increased among temephos-resistant mosquitoes compared to reference strains. The evidence is strong that PPF does increase immature mortality and adult inhibition in settings represented in the included studies, however future research should focus on areas where there is less evidence (e.g. auto-dissemination, sprays) and new use cases for PPF. A better understanding of the biological mechanisms of cross-resistance between PPF, temephos, and other insecticides will allow control programs to make better ... |
format |
Article in Journal/Newspaper |
author |
John Christian Hustedt Ross Boyce John Bradley Jeffrey Hii Neal Alexander |
author_facet |
John Christian Hustedt Ross Boyce John Bradley Jeffrey Hii Neal Alexander |
author_sort |
John Christian Hustedt |
title |
Use of pyriproxyfen in control of Aedes mosquitoes: A systematic review. |
title_short |
Use of pyriproxyfen in control of Aedes mosquitoes: A systematic review. |
title_full |
Use of pyriproxyfen in control of Aedes mosquitoes: A systematic review. |
title_fullStr |
Use of pyriproxyfen in control of Aedes mosquitoes: A systematic review. |
title_full_unstemmed |
Use of pyriproxyfen in control of Aedes mosquitoes: A systematic review. |
title_sort |
use of pyriproxyfen in control of aedes mosquitoes: a systematic review. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2020 |
url |
https://doi.org/10.1371/journal.pntd.0008205 https://doaj.org/article/960e8312c4594cdfb10f71f7dad037e7 |
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Arctic |
geographic_facet |
Arctic |
genre |
Arctic ulv |
genre_facet |
Arctic ulv |
op_source |
PLoS Neglected Tropical Diseases, Vol 14, Iss 6, p e0008205 (2020) |
op_relation |
https://doi.org/10.1371/journal.pntd.0008205 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0008205 https://doaj.org/article/960e8312c4594cdfb10f71f7dad037e7 |
op_doi |
https://doi.org/10.1371/journal.pntd.0008205 |
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PLOS Neglected Tropical Diseases |
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14 |
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6 |
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e0008205 |
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