Brief inhalation of sevoflurane can reduce glial scar formation after hypoxic-ischemic brain injury in neonatal rats
Previous studies have demonstrated that sevoflurane postconditioning can provide neuroprotection after hypoxic-ischemic injury and improve learning and memory function in developing rodent brains. The classical Rice-Vannucci model was used to induce hypoxic-ischemic injury, and newborn (postnatal da...
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Wolters Kluwer Medknow Publications
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ftdoajarticles:oai:doaj.org/article:960c5368544a4e329c6da1c2bd0ef023 2023-05-15T18:15:17+02:00 Brief inhalation of sevoflurane can reduce glial scar formation after hypoxic-ischemic brain injury in neonatal rats Qiu-Shi Gao Ya-Han Zhang Hang Xue Zi-Yi Wu Chang Li Ping Zhao 2021-01-01T00:00:00Z https://doi.org/10.4103/1673-5374.300456 https://doaj.org/article/960c5368544a4e329c6da1c2bd0ef023 EN eng Wolters Kluwer Medknow Publications http://www.nrronline.org/article.asp?issn=1673-5374;year=2021;volume=16;issue=6;spage=1052;epage=1061;aulast=Gao https://doaj.org/toc/1673-5374 1673-5374 doi:10.4103/1673-5374.300456 https://doaj.org/article/960c5368544a4e329c6da1c2bd0ef023 Neural Regeneration Research, Vol 16, Iss 6, Pp 1052-1061 (2021) brain injury brain central nervous system in vivo injury model plasticity rat recovery regeneration repair Neurology. Diseases of the nervous system RC346-429 article 2021 ftdoajarticles https://doi.org/10.4103/1673-5374.300456 2022-12-31T06:26:32Z Previous studies have demonstrated that sevoflurane postconditioning can provide neuroprotection after hypoxic-ischemic injury and improve learning and memory function in developing rodent brains. The classical Rice-Vannucci model was used to induce hypoxic-ischemic injury, and newborn (postnatal day 7) rats were treated with 2.4% sevoflurane for 30 minutes after hypoxic-ischemic injury. Our results showed that sevoflurane postconditioning significantly improved the learning and memory function of rats, decreased astrogliosis and glial scar formation, increased numbers of dendritic spines, and protected the histomorphology of the hippocampus. Mechanistically, sevoflurane postconditioning decreased expression of von Hippel-Lindau of hypoxia-inducible factor-1α and increased expression of DJ-1. Injection of 1.52 μg of the hypoxia-inducible factor-1α inhibitor YC-1 (Lificiguat) into the left lateral ventricle 30 minutes before hypoxic-ischemic injury reversed the neuroprotection induced by sevoflurane. This finding suggests that sevoflurane can effectively alleviate astrogliosis in the hippocampus and reduce learning and memory impairments caused by glial scar formation after hypoxic-ischemic injury. The underlying mechanism may be related to upregulated DJ-1 expression, reduced ubiquitination of hypoxia-inducible factor-1α, and stabilized hypoxia-inducible factor-1α expression. This study was approved by the Laboratory Animal Care Committee of China Medical University, China (approval No. 2016PS337K) on November 9, 2016. Article in Journal/Newspaper SCAR Directory of Open Access Journals: DOAJ Articles Neural Regeneration Research 16 6 1052 |
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brain injury brain central nervous system in vivo injury model plasticity rat recovery regeneration repair Neurology. Diseases of the nervous system RC346-429 |
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brain injury brain central nervous system in vivo injury model plasticity rat recovery regeneration repair Neurology. Diseases of the nervous system RC346-429 Qiu-Shi Gao Ya-Han Zhang Hang Xue Zi-Yi Wu Chang Li Ping Zhao Brief inhalation of sevoflurane can reduce glial scar formation after hypoxic-ischemic brain injury in neonatal rats |
topic_facet |
brain injury brain central nervous system in vivo injury model plasticity rat recovery regeneration repair Neurology. Diseases of the nervous system RC346-429 |
description |
Previous studies have demonstrated that sevoflurane postconditioning can provide neuroprotection after hypoxic-ischemic injury and improve learning and memory function in developing rodent brains. The classical Rice-Vannucci model was used to induce hypoxic-ischemic injury, and newborn (postnatal day 7) rats were treated with 2.4% sevoflurane for 30 minutes after hypoxic-ischemic injury. Our results showed that sevoflurane postconditioning significantly improved the learning and memory function of rats, decreased astrogliosis and glial scar formation, increased numbers of dendritic spines, and protected the histomorphology of the hippocampus. Mechanistically, sevoflurane postconditioning decreased expression of von Hippel-Lindau of hypoxia-inducible factor-1α and increased expression of DJ-1. Injection of 1.52 μg of the hypoxia-inducible factor-1α inhibitor YC-1 (Lificiguat) into the left lateral ventricle 30 minutes before hypoxic-ischemic injury reversed the neuroprotection induced by sevoflurane. This finding suggests that sevoflurane can effectively alleviate astrogliosis in the hippocampus and reduce learning and memory impairments caused by glial scar formation after hypoxic-ischemic injury. The underlying mechanism may be related to upregulated DJ-1 expression, reduced ubiquitination of hypoxia-inducible factor-1α, and stabilized hypoxia-inducible factor-1α expression. This study was approved by the Laboratory Animal Care Committee of China Medical University, China (approval No. 2016PS337K) on November 9, 2016. |
format |
Article in Journal/Newspaper |
author |
Qiu-Shi Gao Ya-Han Zhang Hang Xue Zi-Yi Wu Chang Li Ping Zhao |
author_facet |
Qiu-Shi Gao Ya-Han Zhang Hang Xue Zi-Yi Wu Chang Li Ping Zhao |
author_sort |
Qiu-Shi Gao |
title |
Brief inhalation of sevoflurane can reduce glial scar formation after hypoxic-ischemic brain injury in neonatal rats |
title_short |
Brief inhalation of sevoflurane can reduce glial scar formation after hypoxic-ischemic brain injury in neonatal rats |
title_full |
Brief inhalation of sevoflurane can reduce glial scar formation after hypoxic-ischemic brain injury in neonatal rats |
title_fullStr |
Brief inhalation of sevoflurane can reduce glial scar formation after hypoxic-ischemic brain injury in neonatal rats |
title_full_unstemmed |
Brief inhalation of sevoflurane can reduce glial scar formation after hypoxic-ischemic brain injury in neonatal rats |
title_sort |
brief inhalation of sevoflurane can reduce glial scar formation after hypoxic-ischemic brain injury in neonatal rats |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2021 |
url |
https://doi.org/10.4103/1673-5374.300456 https://doaj.org/article/960c5368544a4e329c6da1c2bd0ef023 |
genre |
SCAR |
genre_facet |
SCAR |
op_source |
Neural Regeneration Research, Vol 16, Iss 6, Pp 1052-1061 (2021) |
op_relation |
http://www.nrronline.org/article.asp?issn=1673-5374;year=2021;volume=16;issue=6;spage=1052;epage=1061;aulast=Gao https://doaj.org/toc/1673-5374 1673-5374 doi:10.4103/1673-5374.300456 https://doaj.org/article/960c5368544a4e329c6da1c2bd0ef023 |
op_doi |
https://doi.org/10.4103/1673-5374.300456 |
container_title |
Neural Regeneration Research |
container_volume |
16 |
container_issue |
6 |
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1052 |
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1766188386471641088 |