Cutaneous leishmaniasis and co-morbid major depressive disorder: A systematic review with burden estimates.
BACKGROUND:Major depressive disorder (MDD) associated with chronic neglected tropical diseases (NTDs) has been identified as a significant and overlooked contributor to overall disease burden. Cutaneous leishmaniasis (CL) is one of the most prevalent and stigmatising NTDs, with an incidence of aroun...
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ftdoajarticles:oai:doaj.org/article:95774b70efc34d4f82e231f59ba19356 2023-05-15T15:11:40+02:00 Cutaneous leishmaniasis and co-morbid major depressive disorder: A systematic review with burden estimates. Freddie Bailey Karina Mondragon-Shem Lee Rafuse Haines Amina Olabi Ahmed Alorfi José Antonio Ruiz-Postigo Jorge Alvar Peter Hotez Emily R Adams Iván D Vélez Waleed Al-Salem Julian Eaton Álvaro Acosta-Serrano David H Molyneux 2019-02-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0007092 https://doaj.org/article/95774b70efc34d4f82e231f59ba19356 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC6405174?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0007092 https://doaj.org/article/95774b70efc34d4f82e231f59ba19356 PLoS Neglected Tropical Diseases, Vol 13, Iss 2, p e0007092 (2019) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2019 ftdoajarticles https://doi.org/10.1371/journal.pntd.0007092 2022-12-31T04:15:03Z BACKGROUND:Major depressive disorder (MDD) associated with chronic neglected tropical diseases (NTDs) has been identified as a significant and overlooked contributor to overall disease burden. Cutaneous leishmaniasis (CL) is one of the most prevalent and stigmatising NTDs, with an incidence of around 1 million new cases of active CL infection annually. However, the characteristic residual scarring (inactive CL) following almost all cases of active CL has only recently been recognised as part of the CL disease spectrum due to its lasting psychosocial impact. METHODS AND FINDINGS:We performed a multi-language systematic review of the psychosocial impact of active and inactive CL. We estimated inactive CL (iCL) prevalence for the first time using reported WHO active CL (aCL) incidence data that were adjusted for life expectancy and underreporting. We then quantified the disability (YLD) burden of co-morbid MDD in CL using MDD disability weights at three severity levels. Overall, we identified 29 studies of CL psychological impact from 5 WHO regions, representing 11 of the 50 highest burden countries for CL. We conservatively calculated the disability burden of co-morbid MDD in CL to be 1.9 million YLDs, which equalled the overall (DALY) disease burden (assuming no excess mortality in depressed CL patients). Thus, upon inclusion of co-morbid MDD alone in both active and inactive CL, the DALY burden was seven times higher than the latest 2016 Global Burden of Disease study estimates, which notably omitted both psychological impact and inactive CL. CONCLUSIONS:Failure to include co-morbid MDD and the lasting sequelae of chronic NTDs, as exemplified by CL, leads to large underestimates of overall disease burden. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Daly ENVELOPE(63.761,63.761,-67.513,-67.513) PLOS Neglected Tropical Diseases 13 2 e0007092 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Freddie Bailey Karina Mondragon-Shem Lee Rafuse Haines Amina Olabi Ahmed Alorfi José Antonio Ruiz-Postigo Jorge Alvar Peter Hotez Emily R Adams Iván D Vélez Waleed Al-Salem Julian Eaton Álvaro Acosta-Serrano David H Molyneux Cutaneous leishmaniasis and co-morbid major depressive disorder: A systematic review with burden estimates. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
BACKGROUND:Major depressive disorder (MDD) associated with chronic neglected tropical diseases (NTDs) has been identified as a significant and overlooked contributor to overall disease burden. Cutaneous leishmaniasis (CL) is one of the most prevalent and stigmatising NTDs, with an incidence of around 1 million new cases of active CL infection annually. However, the characteristic residual scarring (inactive CL) following almost all cases of active CL has only recently been recognised as part of the CL disease spectrum due to its lasting psychosocial impact. METHODS AND FINDINGS:We performed a multi-language systematic review of the psychosocial impact of active and inactive CL. We estimated inactive CL (iCL) prevalence for the first time using reported WHO active CL (aCL) incidence data that were adjusted for life expectancy and underreporting. We then quantified the disability (YLD) burden of co-morbid MDD in CL using MDD disability weights at three severity levels. Overall, we identified 29 studies of CL psychological impact from 5 WHO regions, representing 11 of the 50 highest burden countries for CL. We conservatively calculated the disability burden of co-morbid MDD in CL to be 1.9 million YLDs, which equalled the overall (DALY) disease burden (assuming no excess mortality in depressed CL patients). Thus, upon inclusion of co-morbid MDD alone in both active and inactive CL, the DALY burden was seven times higher than the latest 2016 Global Burden of Disease study estimates, which notably omitted both psychological impact and inactive CL. CONCLUSIONS:Failure to include co-morbid MDD and the lasting sequelae of chronic NTDs, as exemplified by CL, leads to large underestimates of overall disease burden. |
format |
Article in Journal/Newspaper |
author |
Freddie Bailey Karina Mondragon-Shem Lee Rafuse Haines Amina Olabi Ahmed Alorfi José Antonio Ruiz-Postigo Jorge Alvar Peter Hotez Emily R Adams Iván D Vélez Waleed Al-Salem Julian Eaton Álvaro Acosta-Serrano David H Molyneux |
author_facet |
Freddie Bailey Karina Mondragon-Shem Lee Rafuse Haines Amina Olabi Ahmed Alorfi José Antonio Ruiz-Postigo Jorge Alvar Peter Hotez Emily R Adams Iván D Vélez Waleed Al-Salem Julian Eaton Álvaro Acosta-Serrano David H Molyneux |
author_sort |
Freddie Bailey |
title |
Cutaneous leishmaniasis and co-morbid major depressive disorder: A systematic review with burden estimates. |
title_short |
Cutaneous leishmaniasis and co-morbid major depressive disorder: A systematic review with burden estimates. |
title_full |
Cutaneous leishmaniasis and co-morbid major depressive disorder: A systematic review with burden estimates. |
title_fullStr |
Cutaneous leishmaniasis and co-morbid major depressive disorder: A systematic review with burden estimates. |
title_full_unstemmed |
Cutaneous leishmaniasis and co-morbid major depressive disorder: A systematic review with burden estimates. |
title_sort |
cutaneous leishmaniasis and co-morbid major depressive disorder: a systematic review with burden estimates. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2019 |
url |
https://doi.org/10.1371/journal.pntd.0007092 https://doaj.org/article/95774b70efc34d4f82e231f59ba19356 |
long_lat |
ENVELOPE(63.761,63.761,-67.513,-67.513) |
geographic |
Arctic Daly |
geographic_facet |
Arctic Daly |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 13, Iss 2, p e0007092 (2019) |
op_relation |
http://europepmc.org/articles/PMC6405174?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0007092 https://doaj.org/article/95774b70efc34d4f82e231f59ba19356 |
op_doi |
https://doi.org/10.1371/journal.pntd.0007092 |
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PLOS Neglected Tropical Diseases |
container_volume |
13 |
container_issue |
2 |
container_start_page |
e0007092 |
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1766342496080625664 |