Diagnosis of Persistent Fever in the Tropics: Set of Standard Operating Procedures Used in the NIDIAG Febrile Syndrome Study.
In resource-limited settings, the scarcity of skilled personnel and adequate laboratory facilities makes the differential diagnosis of fevers complex [1-5]. Febrile illnesses are diagnosed clinically in most rural centers, and both Rapid Diagnostic Tests (RDTs) and clinical algorithms can be valuabl...
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ftdoajarticles:oai:doaj.org/article:94f42276fbda4488a02a00f445b70ff3 2023-05-15T15:08:04+02:00 Diagnosis of Persistent Fever in the Tropics: Set of Standard Operating Procedures Used in the NIDIAG Febrile Syndrome Study. Emilie Alirol Ninon Seiko Horie Barbara Barbé Veerle Lejon Kristien Verdonck Philippe Gillet Jan Jacobs Philippe Büscher Basudha Kanal Narayan Raj Bhattarai Sayda El Safi Thong Phe Kruy Lim Long Leng Pascal Lutumba Deby Mukendi Emmanuel Bottieau Marleen Boelaert Suman Rijal François Chappuis 2016-11-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0004749 https://doaj.org/article/94f42276fbda4488a02a00f445b70ff3 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC5094701?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0004749 https://doaj.org/article/94f42276fbda4488a02a00f445b70ff3 PLoS Neglected Tropical Diseases, Vol 10, Iss 11, p e0004749 (2016) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2016 ftdoajarticles https://doi.org/10.1371/journal.pntd.0004749 2022-12-31T05:57:09Z In resource-limited settings, the scarcity of skilled personnel and adequate laboratory facilities makes the differential diagnosis of fevers complex [1-5]. Febrile illnesses are diagnosed clinically in most rural centers, and both Rapid Diagnostic Tests (RDTs) and clinical algorithms can be valuable aids to health workers and facilitate therapeutic decisions [6,7]. The persistent fever syndrome targeted by NIDIAG is defined as presence of fever for at least one week. The NIDIAG clinical research consortium focused on potentially severe and treatable infections and therefore targeted the following conditions as differential diagnosis of persistent fever: visceral leishmaniasis (VL), human African trypanosomiasis (HAT), enteric (typhoid and paratyphoid) fever, brucellosis, melioidosis, leptospirosis, malaria, tuberculosis, amoebic liver abscess, relapsing fever, HIV/AIDS, rickettsiosis, and other infectious diseases (e.g., pneumonia). From January 2013 to October 2014, a prospective clinical phase III diagnostic accuracy study was conducted in one site in Cambodia, two sites in Nepal, two sites in Democratic Republic of the Congo (DRC), and one site in Sudan (clinicaltrials.gov no. NCT01766830). The study objectives were to (1) determine the prevalence of the target diseases in patients presenting with persistent fever, (2) assess the predictive value of clinical and first-line laboratory features, and (3) assess the diagnostic accuracy of several RDTs for the diagnosis of the different target conditions. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 10 11 e0004749 |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Emilie Alirol Ninon Seiko Horie Barbara Barbé Veerle Lejon Kristien Verdonck Philippe Gillet Jan Jacobs Philippe Büscher Basudha Kanal Narayan Raj Bhattarai Sayda El Safi Thong Phe Kruy Lim Long Leng Pascal Lutumba Deby Mukendi Emmanuel Bottieau Marleen Boelaert Suman Rijal François Chappuis Diagnosis of Persistent Fever in the Tropics: Set of Standard Operating Procedures Used in the NIDIAG Febrile Syndrome Study. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
In resource-limited settings, the scarcity of skilled personnel and adequate laboratory facilities makes the differential diagnosis of fevers complex [1-5]. Febrile illnesses are diagnosed clinically in most rural centers, and both Rapid Diagnostic Tests (RDTs) and clinical algorithms can be valuable aids to health workers and facilitate therapeutic decisions [6,7]. The persistent fever syndrome targeted by NIDIAG is defined as presence of fever for at least one week. The NIDIAG clinical research consortium focused on potentially severe and treatable infections and therefore targeted the following conditions as differential diagnosis of persistent fever: visceral leishmaniasis (VL), human African trypanosomiasis (HAT), enteric (typhoid and paratyphoid) fever, brucellosis, melioidosis, leptospirosis, malaria, tuberculosis, amoebic liver abscess, relapsing fever, HIV/AIDS, rickettsiosis, and other infectious diseases (e.g., pneumonia). From January 2013 to October 2014, a prospective clinical phase III diagnostic accuracy study was conducted in one site in Cambodia, two sites in Nepal, two sites in Democratic Republic of the Congo (DRC), and one site in Sudan (clinicaltrials.gov no. NCT01766830). The study objectives were to (1) determine the prevalence of the target diseases in patients presenting with persistent fever, (2) assess the predictive value of clinical and first-line laboratory features, and (3) assess the diagnostic accuracy of several RDTs for the diagnosis of the different target conditions. |
format |
Article in Journal/Newspaper |
author |
Emilie Alirol Ninon Seiko Horie Barbara Barbé Veerle Lejon Kristien Verdonck Philippe Gillet Jan Jacobs Philippe Büscher Basudha Kanal Narayan Raj Bhattarai Sayda El Safi Thong Phe Kruy Lim Long Leng Pascal Lutumba Deby Mukendi Emmanuel Bottieau Marleen Boelaert Suman Rijal François Chappuis |
author_facet |
Emilie Alirol Ninon Seiko Horie Barbara Barbé Veerle Lejon Kristien Verdonck Philippe Gillet Jan Jacobs Philippe Büscher Basudha Kanal Narayan Raj Bhattarai Sayda El Safi Thong Phe Kruy Lim Long Leng Pascal Lutumba Deby Mukendi Emmanuel Bottieau Marleen Boelaert Suman Rijal François Chappuis |
author_sort |
Emilie Alirol |
title |
Diagnosis of Persistent Fever in the Tropics: Set of Standard Operating Procedures Used in the NIDIAG Febrile Syndrome Study. |
title_short |
Diagnosis of Persistent Fever in the Tropics: Set of Standard Operating Procedures Used in the NIDIAG Febrile Syndrome Study. |
title_full |
Diagnosis of Persistent Fever in the Tropics: Set of Standard Operating Procedures Used in the NIDIAG Febrile Syndrome Study. |
title_fullStr |
Diagnosis of Persistent Fever in the Tropics: Set of Standard Operating Procedures Used in the NIDIAG Febrile Syndrome Study. |
title_full_unstemmed |
Diagnosis of Persistent Fever in the Tropics: Set of Standard Operating Procedures Used in the NIDIAG Febrile Syndrome Study. |
title_sort |
diagnosis of persistent fever in the tropics: set of standard operating procedures used in the nidiag febrile syndrome study. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2016 |
url |
https://doi.org/10.1371/journal.pntd.0004749 https://doaj.org/article/94f42276fbda4488a02a00f445b70ff3 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 10, Iss 11, p e0004749 (2016) |
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http://europepmc.org/articles/PMC5094701?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0004749 https://doaj.org/article/94f42276fbda4488a02a00f445b70ff3 |
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https://doi.org/10.1371/journal.pntd.0004749 |
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PLOS Neglected Tropical Diseases |
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10 |
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11 |
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e0004749 |
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