Case-area targeted preventive interventions to interrupt cholera transmission: Current implementation practices and lessons learned.
Background Cholera is a major cause of mortality and morbidity in low-resource and humanitarian settings. It is transmitted by fecal-oral route, and the infection risk is higher to those living in and near cholera cases. Rapid identification of cholera cases and implementation of measures to prevent...
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ftdoajarticles:oai:doaj.org/article:946746e539bb4756a3f3a281333abc66 2023-05-15T15:14:30+02:00 Case-area targeted preventive interventions to interrupt cholera transmission: Current implementation practices and lessons learned. Mustafa Sikder Chiara Altare Shannon Doocy Daniella Trowbridge Gurpreet Kaur Natasha Kaushal Emily Lyles Daniele Lantagne Andrew S Azman Paul Spiegel 2021-12-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0010042 https://doaj.org/article/946746e539bb4756a3f3a281333abc66 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0010042 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0010042 https://doaj.org/article/946746e539bb4756a3f3a281333abc66 PLoS Neglected Tropical Diseases, Vol 15, Iss 12, p e0010042 (2021) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2021 ftdoajarticles https://doi.org/10.1371/journal.pntd.0010042 2022-12-31T15:19:43Z Background Cholera is a major cause of mortality and morbidity in low-resource and humanitarian settings. It is transmitted by fecal-oral route, and the infection risk is higher to those living in and near cholera cases. Rapid identification of cholera cases and implementation of measures to prevent subsequent transmission around cases may be an efficient strategy to reduce the size and scale of cholera outbreaks. Methodology/principle findings We investigated implementation of cholera case-area targeted interventions (CATIs) using systematic reviews and case studies. We identified 11 peer-reviewed and eight grey literature articles documenting CATIs and completed 30 key informant interviews in case studies in Democratic Republic of Congo, Haiti, Yemen, and Zimbabwe. We documented 15 outbreaks in 12 countries where CATIs were used. The team composition and the interventions varied, with water, sanitation, and hygiene interventions implemented more commonly than those of health. Alert systems triggering interventions were diverse ranging from suspected cholera cases to culture confirmed cases. Selection of high-risk households around the case household was inconsistent and ranged from only one case to approximately 100 surrounding households with different methods of selecting them. Coordination among actors and integration between sectors were consistently reported as challenging. Delays in sharing case information impeded rapid implementation of this approach, while evaluation of the effectiveness of interventions varied. Conclusions/significance CATIs appear effective in reducing cholera outbreaks, but there is limited and context specific evidence of their effectiveness in reducing the incidence of cholera cases and lack of guidance for their consistent implementation. We propose to 1) use uniform cholera case definitions considering a local capacity to trigger alert; 2) evaluate the effectiveness of individual or sets of interventions to interrupt cholera, and establish a set of evidence-based interventions; ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 15 12 e0010042 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Mustafa Sikder Chiara Altare Shannon Doocy Daniella Trowbridge Gurpreet Kaur Natasha Kaushal Emily Lyles Daniele Lantagne Andrew S Azman Paul Spiegel Case-area targeted preventive interventions to interrupt cholera transmission: Current implementation practices and lessons learned. |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Background Cholera is a major cause of mortality and morbidity in low-resource and humanitarian settings. It is transmitted by fecal-oral route, and the infection risk is higher to those living in and near cholera cases. Rapid identification of cholera cases and implementation of measures to prevent subsequent transmission around cases may be an efficient strategy to reduce the size and scale of cholera outbreaks. Methodology/principle findings We investigated implementation of cholera case-area targeted interventions (CATIs) using systematic reviews and case studies. We identified 11 peer-reviewed and eight grey literature articles documenting CATIs and completed 30 key informant interviews in case studies in Democratic Republic of Congo, Haiti, Yemen, and Zimbabwe. We documented 15 outbreaks in 12 countries where CATIs were used. The team composition and the interventions varied, with water, sanitation, and hygiene interventions implemented more commonly than those of health. Alert systems triggering interventions were diverse ranging from suspected cholera cases to culture confirmed cases. Selection of high-risk households around the case household was inconsistent and ranged from only one case to approximately 100 surrounding households with different methods of selecting them. Coordination among actors and integration between sectors were consistently reported as challenging. Delays in sharing case information impeded rapid implementation of this approach, while evaluation of the effectiveness of interventions varied. Conclusions/significance CATIs appear effective in reducing cholera outbreaks, but there is limited and context specific evidence of their effectiveness in reducing the incidence of cholera cases and lack of guidance for their consistent implementation. We propose to 1) use uniform cholera case definitions considering a local capacity to trigger alert; 2) evaluate the effectiveness of individual or sets of interventions to interrupt cholera, and establish a set of evidence-based interventions; ... |
format |
Article in Journal/Newspaper |
author |
Mustafa Sikder Chiara Altare Shannon Doocy Daniella Trowbridge Gurpreet Kaur Natasha Kaushal Emily Lyles Daniele Lantagne Andrew S Azman Paul Spiegel |
author_facet |
Mustafa Sikder Chiara Altare Shannon Doocy Daniella Trowbridge Gurpreet Kaur Natasha Kaushal Emily Lyles Daniele Lantagne Andrew S Azman Paul Spiegel |
author_sort |
Mustafa Sikder |
title |
Case-area targeted preventive interventions to interrupt cholera transmission: Current implementation practices and lessons learned. |
title_short |
Case-area targeted preventive interventions to interrupt cholera transmission: Current implementation practices and lessons learned. |
title_full |
Case-area targeted preventive interventions to interrupt cholera transmission: Current implementation practices and lessons learned. |
title_fullStr |
Case-area targeted preventive interventions to interrupt cholera transmission: Current implementation practices and lessons learned. |
title_full_unstemmed |
Case-area targeted preventive interventions to interrupt cholera transmission: Current implementation practices and lessons learned. |
title_sort |
case-area targeted preventive interventions to interrupt cholera transmission: current implementation practices and lessons learned. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2021 |
url |
https://doi.org/10.1371/journal.pntd.0010042 https://doaj.org/article/946746e539bb4756a3f3a281333abc66 |
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Arctic |
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Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 15, Iss 12, p e0010042 (2021) |
op_relation |
https://doi.org/10.1371/journal.pntd.0010042 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0010042 https://doaj.org/article/946746e539bb4756a3f3a281333abc66 |
op_doi |
https://doi.org/10.1371/journal.pntd.0010042 |
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PLOS Neglected Tropical Diseases |
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15 |
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12 |
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e0010042 |
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