Interval between first dose and booster affected antibody production in cattle vaccinated against rabies
In this study, we compared the levels of neutralizing antibodies induced by inactivated rabies vaccine in cattle by using three alternative immunization procedures. Forty-five bovines (breed nelore) were then organized in three groups (A, B and C, with 15 animals/group). Group A received only one va...
Published in: | Journal of Venomous Animals and Toxins including Tropical Diseases |
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Online Access: | https://doi.org/10.1590/S1678-91992006000300010 https://doaj.org/article/9457e946ade1475fa37ccd81c9a25896 |
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ftdoajarticles:oai:doaj.org/article:9457e946ade1475fa37ccd81c9a25896 2023-05-15T15:07:16+02:00 Interval between first dose and booster affected antibody production in cattle vaccinated against rabies A. Albas O. L. Fontolan P. E. Pardo H. Bremer Neto A. Sartori 2006-01-01T00:00:00Z https://doi.org/10.1590/S1678-91992006000300010 https://doaj.org/article/9457e946ade1475fa37ccd81c9a25896 EN eng SciELO http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992006000300010 https://doaj.org/toc/1678-9199 doi:10.1590/S1678-91992006000300010 1678-9199 https://doaj.org/article/9457e946ade1475fa37ccd81c9a25896 Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 12, Iss 3, Pp 476-486 (2006) rabies vaccine cattle antibody neutralization Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 article 2006 ftdoajarticles https://doi.org/10.1590/S1678-91992006000300010 2022-12-31T14:28:51Z In this study, we compared the levels of neutralizing antibodies induced by inactivated rabies vaccine in cattle by using three alternative immunization procedures. Forty-five bovines (breed nelore) were then organized in three groups (A, B and C, with 15 animals/group). Group A received only one vaccine dose at day zero and Group B received the first dose at day zero and then another dose at day 30 (early booster). Group C was also immunized with two doses; however, the booster was postponed until day 180 after the first dose (delayed booster). Blood samples were withdrawn at days zero (before the first dose) and 30, 210, 390, and 540 after the beginning of immunization and the antibody titers were evaluated by mouse neutralization test. The protocol used to immunize Group C (booster at day 180) was clearly more efficient. In this group, antibody levels were higher and also remained higher for longer periods in comparison with the other two groups. These results show that booster timing significantly affected antibody levels. Therefore, programs addressed to control this disease in cattle should consider not only the use of a booster but also its administration time. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of Venomous Animals and Toxins including Tropical Diseases 12 3 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
rabies vaccine cattle antibody neutralization Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
spellingShingle |
rabies vaccine cattle antibody neutralization Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 A. Albas O. L. Fontolan P. E. Pardo H. Bremer Neto A. Sartori Interval between first dose and booster affected antibody production in cattle vaccinated against rabies |
topic_facet |
rabies vaccine cattle antibody neutralization Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
description |
In this study, we compared the levels of neutralizing antibodies induced by inactivated rabies vaccine in cattle by using three alternative immunization procedures. Forty-five bovines (breed nelore) were then organized in three groups (A, B and C, with 15 animals/group). Group A received only one vaccine dose at day zero and Group B received the first dose at day zero and then another dose at day 30 (early booster). Group C was also immunized with two doses; however, the booster was postponed until day 180 after the first dose (delayed booster). Blood samples were withdrawn at days zero (before the first dose) and 30, 210, 390, and 540 after the beginning of immunization and the antibody titers were evaluated by mouse neutralization test. The protocol used to immunize Group C (booster at day 180) was clearly more efficient. In this group, antibody levels were higher and also remained higher for longer periods in comparison with the other two groups. These results show that booster timing significantly affected antibody levels. Therefore, programs addressed to control this disease in cattle should consider not only the use of a booster but also its administration time. |
format |
Article in Journal/Newspaper |
author |
A. Albas O. L. Fontolan P. E. Pardo H. Bremer Neto A. Sartori |
author_facet |
A. Albas O. L. Fontolan P. E. Pardo H. Bremer Neto A. Sartori |
author_sort |
A. Albas |
title |
Interval between first dose and booster affected antibody production in cattle vaccinated against rabies |
title_short |
Interval between first dose and booster affected antibody production in cattle vaccinated against rabies |
title_full |
Interval between first dose and booster affected antibody production in cattle vaccinated against rabies |
title_fullStr |
Interval between first dose and booster affected antibody production in cattle vaccinated against rabies |
title_full_unstemmed |
Interval between first dose and booster affected antibody production in cattle vaccinated against rabies |
title_sort |
interval between first dose and booster affected antibody production in cattle vaccinated against rabies |
publisher |
SciELO |
publishDate |
2006 |
url |
https://doi.org/10.1590/S1678-91992006000300010 https://doaj.org/article/9457e946ade1475fa37ccd81c9a25896 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 12, Iss 3, Pp 476-486 (2006) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992006000300010 https://doaj.org/toc/1678-9199 doi:10.1590/S1678-91992006000300010 1678-9199 https://doaj.org/article/9457e946ade1475fa37ccd81c9a25896 |
op_doi |
https://doi.org/10.1590/S1678-91992006000300010 |
container_title |
Journal of Venomous Animals and Toxins including Tropical Diseases |
container_volume |
12 |
container_issue |
3 |
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1766338803039993856 |