Improving tuberculosis control through the partnership between university and the health system Qualificar o controle da tuberculose mediante a parceria entre a Universidade e o Sistema de Saúde
INTRODUCTION: Tuberculosis (TB) control is linked to the availability of qualified methods for microbiological diagnostics; however, microscopy with limited sensitivity is the only method available in many locations. The objective of this study was to evaluate the introduction of culture, drug susce...
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Sociedade Brasileira de Medicina Tropical (SBMT)
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ftdoajarticles:oai:doaj.org/article:9431613d59f144378adaadbf2ec35c58 2023-05-15T15:14:47+02:00 Improving tuberculosis control through the partnership between university and the health system Qualificar o controle da tuberculose mediante a parceria entre a Universidade e o Sistema de Saúde Mariana Soares Valença Jeane Zanini da Rocha Ivy Bastos Ramis Lillian Lucas Carrion Catiúcia Madruga Maíra Bidart de Macedo Carlos James Scaini Andrea von Groll Pedro Eduardo Almeida da Silva 2012-08-01T00:00:00Z https://doaj.org/article/9431613d59f144378adaadbf2ec35c58 EN eng Sociedade Brasileira de Medicina Tropical (SBMT) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822012000400015 https://doaj.org/toc/0037-8682 https://doaj.org/toc/1678-9849 0037-8682 1678-9849 https://doaj.org/article/9431613d59f144378adaadbf2ec35c58 Revista da Sociedade Brasileira de Medicina Tropical, Vol 45, Iss 4, Pp 491-495 (2012) Mycobacterium tuberculosis Diagnóstico Epidemiologia molecular Diagnostic Molecular epidemiology Arctic medicine. Tropical medicine RC955-962 article 2012 ftdoajarticles 2022-12-30T21:33:26Z INTRODUCTION: Tuberculosis (TB) control is linked to the availability of qualified methods for microbiological diagnostics; however, microscopy with limited sensitivity is the only method available in many locations. The objective of this study was to evaluate the introduction of culture, drug susceptibility testing (DST), and genotyping in the routine of a Municipal Program of Tuberculosis Control. METHODS: Direct microscopy of sputum and culture in Ogawa-Kudoh were performed on 1,636 samples from 787 patients. DST of positive cultures was performed by resazurin microtiter assay and genotyping by mycobacterial interspersed repetitive units-variable number tandem repeat. RESULTS: A total 91 patients with TB were identified. The culture increased case detection by 32% compared with the microscopy; acquired resistance was 3.3% and the genotyping showed high genetic diversity. CONCLUSIONS: Ogawa-Kudoh contributed significantly to the increase in case detection and is suitable for implementation in poor-resource locations. The acquired resistance rate was lower than that reported in a recent Brazilian survey. The high genetic diversity is possibly related to the high TB prevalence in the population, as well as to early detection and suitable treatment of patients. The interaction between research and health care is important for reorienting the practice, transferring technology, and improving TB control. INTRODUÇÃO: O controle da tuberculose (TB) está relacionado com a disponibilidade de métodos de diagnóstico microbiológico qualificados, no entanto a microscopia com a sua limitada sensibilidade é o único método disponível em muitos locais.O objetivo deste estudo foi avaliar a introdução da cultura, teste de sensibilidade aos antimicrobianos (TSA) e genotipagem na rotina de um Programa Municipal de Controle da Tuberculose. MÉTODOS:A baciloscopia direta do escarro e cultura em Ogawa-Kudoh foram realizadas em 1.636 amostras de 787 pacientes. O TSA das culturas positivas foi realizado pelo método de microdiluição e a ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic |
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Directory of Open Access Journals: DOAJ Articles |
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English |
topic |
Mycobacterium tuberculosis Diagnóstico Epidemiologia molecular Diagnostic Molecular epidemiology Arctic medicine. Tropical medicine RC955-962 |
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Mycobacterium tuberculosis Diagnóstico Epidemiologia molecular Diagnostic Molecular epidemiology Arctic medicine. Tropical medicine RC955-962 Mariana Soares Valença Jeane Zanini da Rocha Ivy Bastos Ramis Lillian Lucas Carrion Catiúcia Madruga Maíra Bidart de Macedo Carlos James Scaini Andrea von Groll Pedro Eduardo Almeida da Silva Improving tuberculosis control through the partnership between university and the health system Qualificar o controle da tuberculose mediante a parceria entre a Universidade e o Sistema de Saúde |
topic_facet |
Mycobacterium tuberculosis Diagnóstico Epidemiologia molecular Diagnostic Molecular epidemiology Arctic medicine. Tropical medicine RC955-962 |
description |
INTRODUCTION: Tuberculosis (TB) control is linked to the availability of qualified methods for microbiological diagnostics; however, microscopy with limited sensitivity is the only method available in many locations. The objective of this study was to evaluate the introduction of culture, drug susceptibility testing (DST), and genotyping in the routine of a Municipal Program of Tuberculosis Control. METHODS: Direct microscopy of sputum and culture in Ogawa-Kudoh were performed on 1,636 samples from 787 patients. DST of positive cultures was performed by resazurin microtiter assay and genotyping by mycobacterial interspersed repetitive units-variable number tandem repeat. RESULTS: A total 91 patients with TB were identified. The culture increased case detection by 32% compared with the microscopy; acquired resistance was 3.3% and the genotyping showed high genetic diversity. CONCLUSIONS: Ogawa-Kudoh contributed significantly to the increase in case detection and is suitable for implementation in poor-resource locations. The acquired resistance rate was lower than that reported in a recent Brazilian survey. The high genetic diversity is possibly related to the high TB prevalence in the population, as well as to early detection and suitable treatment of patients. The interaction between research and health care is important for reorienting the practice, transferring technology, and improving TB control. INTRODUÇÃO: O controle da tuberculose (TB) está relacionado com a disponibilidade de métodos de diagnóstico microbiológico qualificados, no entanto a microscopia com a sua limitada sensibilidade é o único método disponível em muitos locais.O objetivo deste estudo foi avaliar a introdução da cultura, teste de sensibilidade aos antimicrobianos (TSA) e genotipagem na rotina de um Programa Municipal de Controle da Tuberculose. MÉTODOS:A baciloscopia direta do escarro e cultura em Ogawa-Kudoh foram realizadas em 1.636 amostras de 787 pacientes. O TSA das culturas positivas foi realizado pelo método de microdiluição e a ... |
format |
Article in Journal/Newspaper |
author |
Mariana Soares Valença Jeane Zanini da Rocha Ivy Bastos Ramis Lillian Lucas Carrion Catiúcia Madruga Maíra Bidart de Macedo Carlos James Scaini Andrea von Groll Pedro Eduardo Almeida da Silva |
author_facet |
Mariana Soares Valença Jeane Zanini da Rocha Ivy Bastos Ramis Lillian Lucas Carrion Catiúcia Madruga Maíra Bidart de Macedo Carlos James Scaini Andrea von Groll Pedro Eduardo Almeida da Silva |
author_sort |
Mariana Soares Valença |
title |
Improving tuberculosis control through the partnership between university and the health system Qualificar o controle da tuberculose mediante a parceria entre a Universidade e o Sistema de Saúde |
title_short |
Improving tuberculosis control through the partnership between university and the health system Qualificar o controle da tuberculose mediante a parceria entre a Universidade e o Sistema de Saúde |
title_full |
Improving tuberculosis control through the partnership between university and the health system Qualificar o controle da tuberculose mediante a parceria entre a Universidade e o Sistema de Saúde |
title_fullStr |
Improving tuberculosis control through the partnership between university and the health system Qualificar o controle da tuberculose mediante a parceria entre a Universidade e o Sistema de Saúde |
title_full_unstemmed |
Improving tuberculosis control through the partnership between university and the health system Qualificar o controle da tuberculose mediante a parceria entre a Universidade e o Sistema de Saúde |
title_sort |
improving tuberculosis control through the partnership between university and the health system qualificar o controle da tuberculose mediante a parceria entre a universidade e o sistema de saúde |
publisher |
Sociedade Brasileira de Medicina Tropical (SBMT) |
publishDate |
2012 |
url |
https://doaj.org/article/9431613d59f144378adaadbf2ec35c58 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista da Sociedade Brasileira de Medicina Tropical, Vol 45, Iss 4, Pp 491-495 (2012) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822012000400015 https://doaj.org/toc/0037-8682 https://doaj.org/toc/1678-9849 0037-8682 1678-9849 https://doaj.org/article/9431613d59f144378adaadbf2ec35c58 |
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1766345195617517568 |