Impaired renal function and increased urinary isoprostane excretion in Ghanaian women with pre-eclampsia
Paul Winston Tetteh,1,4 Charles Antwi-Boasiako,1 Ben Gyan,3 Daniel Antwi,1 Festus Adzaku,1 Kwame Adu-Bonsaffoh,1,2 Samuel Obed21Department of Physiology, 2Department of Obstetrics and Gynecology, University of Ghana Medical School, Accra, Ghana; 3Department of Immunology, Noguchi Memorial Institute...
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ftdoajarticles:oai:doaj.org/article:942e6488af0e43458f72a40409c420d9 2023-05-15T15:16:30+02:00 Impaired renal function and increased urinary isoprostane excretion in Ghanaian women with pre-eclampsia Tetteh PW Antwi-Boasiako C Gyan B Antwi D Adzaku F Adu-Bonsaffoh K Obed S 2013-06-01T00:00:00Z https://doaj.org/article/942e6488af0e43458f72a40409c420d9 EN eng Dove Medical Press http://www.dovepress.com/impaired-renal-function-and-increased-urinary-isoprostane-excretion-in-a13405 https://doaj.org/toc/1179-7282 1179-7282 https://doaj.org/article/942e6488af0e43458f72a40409c420d9 Research and Reports in Tropical Medicine, Vol 2013, Iss default, Pp 7-13 (2013) Arctic medicine. Tropical medicine RC955-962 article 2013 ftdoajarticles 2022-12-31T01:41:44Z Paul Winston Tetteh,1,4 Charles Antwi-Boasiako,1 Ben Gyan,3 Daniel Antwi,1 Festus Adzaku,1 Kwame Adu-Bonsaffoh,1,2 Samuel Obed21Department of Physiology, 2Department of Obstetrics and Gynecology, University of Ghana Medical School, Accra, Ghana; 3Department of Immunology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana; 4Hubrecht Institute for Developmental Biology and Stem Cell Research, Uppsalalaan 8, Utrecht, The NetherlandsBackground: The cause of pre-eclampsia remains largely unknown, but oxidative stress (an imbalance favoring oxidant over antioxidant forces) has been implicated in contributing to the clinical symptoms of hypertension and proteinuria. Assessment of oxidative stress in pre-eclampsia using urinary isoprostane has produced conflicting results, and it is likely that renal function may affect isoprostane excretion. The aim of this study was to determine the role of oxidative stress in the pathophysiology of pre-eclampsia and to assess the effect of renal function on isoprostane excretion in pre-eclampsia in the Ghanaian population.Methods: This was a case-controlled study, comprising 103 pre-eclamptic women and 107 normal pregnant controls and conducted at the Korle-Bu Teaching Hospital between December 2006 and May 2007. The study participants were enrolled in the study after meeting the inclusion criteria and signing their written informed consent. Oxidative stress was determined by measuring urinary excretion of isoprostane and total antioxidant capacity using an enzyme-linked immunosorbent assay technique. Renal function was assessed by calculating the estimated glomerular filtration rate using the Modification of Diet in Renal Disease formula.Results: The pre-eclampsia group had significantly (P = 0.0006) higher urinary isoprostane excretion (2.81 ± 0.14 ng/mg creatinine) than the control group (2.01 ± 0.18 ng/mg creatinine) and a significantly (P = 0.0008) lower total antioxidant power (1.68 ± 0.05 mM) than the control group (1.89 ± 0.04 mM). Urinary ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic |
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Arctic medicine. Tropical medicine RC955-962 |
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Arctic medicine. Tropical medicine RC955-962 Tetteh PW Antwi-Boasiako C Gyan B Antwi D Adzaku F Adu-Bonsaffoh K Obed S Impaired renal function and increased urinary isoprostane excretion in Ghanaian women with pre-eclampsia |
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Arctic medicine. Tropical medicine RC955-962 |
description |
Paul Winston Tetteh,1,4 Charles Antwi-Boasiako,1 Ben Gyan,3 Daniel Antwi,1 Festus Adzaku,1 Kwame Adu-Bonsaffoh,1,2 Samuel Obed21Department of Physiology, 2Department of Obstetrics and Gynecology, University of Ghana Medical School, Accra, Ghana; 3Department of Immunology, Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana; 4Hubrecht Institute for Developmental Biology and Stem Cell Research, Uppsalalaan 8, Utrecht, The NetherlandsBackground: The cause of pre-eclampsia remains largely unknown, but oxidative stress (an imbalance favoring oxidant over antioxidant forces) has been implicated in contributing to the clinical symptoms of hypertension and proteinuria. Assessment of oxidative stress in pre-eclampsia using urinary isoprostane has produced conflicting results, and it is likely that renal function may affect isoprostane excretion. The aim of this study was to determine the role of oxidative stress in the pathophysiology of pre-eclampsia and to assess the effect of renal function on isoprostane excretion in pre-eclampsia in the Ghanaian population.Methods: This was a case-controlled study, comprising 103 pre-eclamptic women and 107 normal pregnant controls and conducted at the Korle-Bu Teaching Hospital between December 2006 and May 2007. The study participants were enrolled in the study after meeting the inclusion criteria and signing their written informed consent. Oxidative stress was determined by measuring urinary excretion of isoprostane and total antioxidant capacity using an enzyme-linked immunosorbent assay technique. Renal function was assessed by calculating the estimated glomerular filtration rate using the Modification of Diet in Renal Disease formula.Results: The pre-eclampsia group had significantly (P = 0.0006) higher urinary isoprostane excretion (2.81 ± 0.14 ng/mg creatinine) than the control group (2.01 ± 0.18 ng/mg creatinine) and a significantly (P = 0.0008) lower total antioxidant power (1.68 ± 0.05 mM) than the control group (1.89 ± 0.04 mM). Urinary ... |
format |
Article in Journal/Newspaper |
author |
Tetteh PW Antwi-Boasiako C Gyan B Antwi D Adzaku F Adu-Bonsaffoh K Obed S |
author_facet |
Tetteh PW Antwi-Boasiako C Gyan B Antwi D Adzaku F Adu-Bonsaffoh K Obed S |
author_sort |
Tetteh PW |
title |
Impaired renal function and increased urinary isoprostane excretion in Ghanaian women with pre-eclampsia |
title_short |
Impaired renal function and increased urinary isoprostane excretion in Ghanaian women with pre-eclampsia |
title_full |
Impaired renal function and increased urinary isoprostane excretion in Ghanaian women with pre-eclampsia |
title_fullStr |
Impaired renal function and increased urinary isoprostane excretion in Ghanaian women with pre-eclampsia |
title_full_unstemmed |
Impaired renal function and increased urinary isoprostane excretion in Ghanaian women with pre-eclampsia |
title_sort |
impaired renal function and increased urinary isoprostane excretion in ghanaian women with pre-eclampsia |
publisher |
Dove Medical Press |
publishDate |
2013 |
url |
https://doaj.org/article/942e6488af0e43458f72a40409c420d9 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Research and Reports in Tropical Medicine, Vol 2013, Iss default, Pp 7-13 (2013) |
op_relation |
http://www.dovepress.com/impaired-renal-function-and-increased-urinary-isoprostane-excretion-in-a13405 https://doaj.org/toc/1179-7282 1179-7282 https://doaj.org/article/942e6488af0e43458f72a40409c420d9 |
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1766346794425384960 |