Dengue infection and miscarriage: a prospective case control study.
BACKGROUND: Dengue is the most prevalent mosquito borne infection worldwide. Vertical transmissions after maternal dengue infection to the fetus and pregnancy losses in relation to dengue illness have been reported. The relationship of dengue to miscarriage is not known. METHOD: We aimed to establis...
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ftdoajarticles:oai:doaj.org/article:940bc228074c46bca1c3fd38c8573b45 2023-05-15T15:15:30+02:00 Dengue infection and miscarriage: a prospective case control study. Peng Chiong Tan May Zaw Soe Khaing Si Lay Seok Mui Wang Shamala Devi Sekaran Siti Zawiah Omar 2012-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0001637 https://doaj.org/article/940bc228074c46bca1c3fd38c8573b45 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC3348154?pdf=render https://doaj.org/toc/1935-2735 1935-2735 doi:10.1371/journal.pntd.0001637 https://doaj.org/article/940bc228074c46bca1c3fd38c8573b45 PLoS Neglected Tropical Diseases, Vol 6, Iss 5, p e1637 (2012) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2012 ftdoajarticles https://doi.org/10.1371/journal.pntd.0001637 2022-12-30T21:23:03Z BACKGROUND: Dengue is the most prevalent mosquito borne infection worldwide. Vertical transmissions after maternal dengue infection to the fetus and pregnancy losses in relation to dengue illness have been reported. The relationship of dengue to miscarriage is not known. METHOD: We aimed to establish the relationship of recent dengue infection and miscarriage. Women who presented with miscarriage (up to 22 weeks gestation) to our hospital were approached to participate in the study. For each case of miscarriage, we recruited 3 controls with viable pregnancies at a similar gestation. A brief questionnaire on recent febrile illness and prior dengue infection was answered. Blood was drawn from participants, processed and the frozen serum was stored. Stored sera were thawed and then tested in batches with dengue specific IgM capture ELISA, dengue non-structural protein 1 (NS1) antigen and dengue specific IgG ELISA tests. Controls remained in the analysis if their pregnancies continued beyond 22 weeks gestation. Tests were run on 116 case and 341 control sera. One case (a misdiagnosed viable early pregnancy) plus 45 controls (39 lost to follow up and six subsequent late miscarriages) were excluded from analysis. FINDINGS: Dengue specific IgM or dengue NS1 antigen (indicating recent dengue infection) was positive in 6/115 (5·2%) cases and 5/296 (1·7%) controls RR 3·1 (95% CI 1·0-10) P = 0·047. Maternal age, gestational age, parity and ethnicity were dissimilar between cases and controls. After adjustments for these factors, recent dengue infection remained significantly more frequently detected in cases than controls (AOR 4·2 95% CI 1·2-14 P = 0·023). INTERPRETATION: Recent dengue infections were more frequently detected in women presenting with miscarriage than in controls whose pregnancies were viable. After adjustments for confounders, the positive association remained. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 6 5 e1637 |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Peng Chiong Tan May Zaw Soe Khaing Si Lay Seok Mui Wang Shamala Devi Sekaran Siti Zawiah Omar Dengue infection and miscarriage: a prospective case control study. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
BACKGROUND: Dengue is the most prevalent mosquito borne infection worldwide. Vertical transmissions after maternal dengue infection to the fetus and pregnancy losses in relation to dengue illness have been reported. The relationship of dengue to miscarriage is not known. METHOD: We aimed to establish the relationship of recent dengue infection and miscarriage. Women who presented with miscarriage (up to 22 weeks gestation) to our hospital were approached to participate in the study. For each case of miscarriage, we recruited 3 controls with viable pregnancies at a similar gestation. A brief questionnaire on recent febrile illness and prior dengue infection was answered. Blood was drawn from participants, processed and the frozen serum was stored. Stored sera were thawed and then tested in batches with dengue specific IgM capture ELISA, dengue non-structural protein 1 (NS1) antigen and dengue specific IgG ELISA tests. Controls remained in the analysis if their pregnancies continued beyond 22 weeks gestation. Tests were run on 116 case and 341 control sera. One case (a misdiagnosed viable early pregnancy) plus 45 controls (39 lost to follow up and six subsequent late miscarriages) were excluded from analysis. FINDINGS: Dengue specific IgM or dengue NS1 antigen (indicating recent dengue infection) was positive in 6/115 (5·2%) cases and 5/296 (1·7%) controls RR 3·1 (95% CI 1·0-10) P = 0·047. Maternal age, gestational age, parity and ethnicity were dissimilar between cases and controls. After adjustments for these factors, recent dengue infection remained significantly more frequently detected in cases than controls (AOR 4·2 95% CI 1·2-14 P = 0·023). INTERPRETATION: Recent dengue infections were more frequently detected in women presenting with miscarriage than in controls whose pregnancies were viable. After adjustments for confounders, the positive association remained. |
format |
Article in Journal/Newspaper |
author |
Peng Chiong Tan May Zaw Soe Khaing Si Lay Seok Mui Wang Shamala Devi Sekaran Siti Zawiah Omar |
author_facet |
Peng Chiong Tan May Zaw Soe Khaing Si Lay Seok Mui Wang Shamala Devi Sekaran Siti Zawiah Omar |
author_sort |
Peng Chiong Tan |
title |
Dengue infection and miscarriage: a prospective case control study. |
title_short |
Dengue infection and miscarriage: a prospective case control study. |
title_full |
Dengue infection and miscarriage: a prospective case control study. |
title_fullStr |
Dengue infection and miscarriage: a prospective case control study. |
title_full_unstemmed |
Dengue infection and miscarriage: a prospective case control study. |
title_sort |
dengue infection and miscarriage: a prospective case control study. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2012 |
url |
https://doi.org/10.1371/journal.pntd.0001637 https://doaj.org/article/940bc228074c46bca1c3fd38c8573b45 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 6, Iss 5, p e1637 (2012) |
op_relation |
http://europepmc.org/articles/PMC3348154?pdf=render https://doaj.org/toc/1935-2735 1935-2735 doi:10.1371/journal.pntd.0001637 https://doaj.org/article/940bc228074c46bca1c3fd38c8573b45 |
op_doi |
https://doi.org/10.1371/journal.pntd.0001637 |
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PLoS Neglected Tropical Diseases |
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6 |
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5 |
container_start_page |
e1637 |
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