Dengue infection and miscarriage: a prospective case control study.

BACKGROUND: Dengue is the most prevalent mosquito borne infection worldwide. Vertical transmissions after maternal dengue infection to the fetus and pregnancy losses in relation to dengue illness have been reported. The relationship of dengue to miscarriage is not known. METHOD: We aimed to establis...

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Published in:PLoS Neglected Tropical Diseases
Main Authors: Peng Chiong Tan, May Zaw Soe, Khaing Si Lay, Seok Mui Wang, Shamala Devi Sekaran, Siti Zawiah Omar
Format: Article in Journal/Newspaper
Language:English
Published: Public Library of Science (PLoS) 2012
Subjects:
Online Access:https://doi.org/10.1371/journal.pntd.0001637
https://doaj.org/article/940bc228074c46bca1c3fd38c8573b45
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spelling ftdoajarticles:oai:doaj.org/article:940bc228074c46bca1c3fd38c8573b45 2023-05-15T15:15:30+02:00 Dengue infection and miscarriage: a prospective case control study. Peng Chiong Tan May Zaw Soe Khaing Si Lay Seok Mui Wang Shamala Devi Sekaran Siti Zawiah Omar 2012-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0001637 https://doaj.org/article/940bc228074c46bca1c3fd38c8573b45 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC3348154?pdf=render https://doaj.org/toc/1935-2735 1935-2735 doi:10.1371/journal.pntd.0001637 https://doaj.org/article/940bc228074c46bca1c3fd38c8573b45 PLoS Neglected Tropical Diseases, Vol 6, Iss 5, p e1637 (2012) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2012 ftdoajarticles https://doi.org/10.1371/journal.pntd.0001637 2022-12-30T21:23:03Z BACKGROUND: Dengue is the most prevalent mosquito borne infection worldwide. Vertical transmissions after maternal dengue infection to the fetus and pregnancy losses in relation to dengue illness have been reported. The relationship of dengue to miscarriage is not known. METHOD: We aimed to establish the relationship of recent dengue infection and miscarriage. Women who presented with miscarriage (up to 22 weeks gestation) to our hospital were approached to participate in the study. For each case of miscarriage, we recruited 3 controls with viable pregnancies at a similar gestation. A brief questionnaire on recent febrile illness and prior dengue infection was answered. Blood was drawn from participants, processed and the frozen serum was stored. Stored sera were thawed and then tested in batches with dengue specific IgM capture ELISA, dengue non-structural protein 1 (NS1) antigen and dengue specific IgG ELISA tests. Controls remained in the analysis if their pregnancies continued beyond 22 weeks gestation. Tests were run on 116 case and 341 control sera. One case (a misdiagnosed viable early pregnancy) plus 45 controls (39 lost to follow up and six subsequent late miscarriages) were excluded from analysis. FINDINGS: Dengue specific IgM or dengue NS1 antigen (indicating recent dengue infection) was positive in 6/115 (5·2%) cases and 5/296 (1·7%) controls RR 3·1 (95% CI 1·0-10) P = 0·047. Maternal age, gestational age, parity and ethnicity were dissimilar between cases and controls. After adjustments for these factors, recent dengue infection remained significantly more frequently detected in cases than controls (AOR 4·2 95% CI 1·2-14 P = 0·023). INTERPRETATION: Recent dengue infections were more frequently detected in women presenting with miscarriage than in controls whose pregnancies were viable. After adjustments for confounders, the positive association remained. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 6 5 e1637
institution Open Polar
collection Directory of Open Access Journals: DOAJ Articles
op_collection_id ftdoajarticles
language English
topic Arctic medicine. Tropical medicine
RC955-962
Public aspects of medicine
RA1-1270
spellingShingle Arctic medicine. Tropical medicine
RC955-962
Public aspects of medicine
RA1-1270
Peng Chiong Tan
May Zaw Soe
Khaing Si Lay
Seok Mui Wang
Shamala Devi Sekaran
Siti Zawiah Omar
Dengue infection and miscarriage: a prospective case control study.
topic_facet Arctic medicine. Tropical medicine
RC955-962
Public aspects of medicine
RA1-1270
description BACKGROUND: Dengue is the most prevalent mosquito borne infection worldwide. Vertical transmissions after maternal dengue infection to the fetus and pregnancy losses in relation to dengue illness have been reported. The relationship of dengue to miscarriage is not known. METHOD: We aimed to establish the relationship of recent dengue infection and miscarriage. Women who presented with miscarriage (up to 22 weeks gestation) to our hospital were approached to participate in the study. For each case of miscarriage, we recruited 3 controls with viable pregnancies at a similar gestation. A brief questionnaire on recent febrile illness and prior dengue infection was answered. Blood was drawn from participants, processed and the frozen serum was stored. Stored sera were thawed and then tested in batches with dengue specific IgM capture ELISA, dengue non-structural protein 1 (NS1) antigen and dengue specific IgG ELISA tests. Controls remained in the analysis if their pregnancies continued beyond 22 weeks gestation. Tests were run on 116 case and 341 control sera. One case (a misdiagnosed viable early pregnancy) plus 45 controls (39 lost to follow up and six subsequent late miscarriages) were excluded from analysis. FINDINGS: Dengue specific IgM or dengue NS1 antigen (indicating recent dengue infection) was positive in 6/115 (5·2%) cases and 5/296 (1·7%) controls RR 3·1 (95% CI 1·0-10) P = 0·047. Maternal age, gestational age, parity and ethnicity were dissimilar between cases and controls. After adjustments for these factors, recent dengue infection remained significantly more frequently detected in cases than controls (AOR 4·2 95% CI 1·2-14 P = 0·023). INTERPRETATION: Recent dengue infections were more frequently detected in women presenting with miscarriage than in controls whose pregnancies were viable. After adjustments for confounders, the positive association remained.
format Article in Journal/Newspaper
author Peng Chiong Tan
May Zaw Soe
Khaing Si Lay
Seok Mui Wang
Shamala Devi Sekaran
Siti Zawiah Omar
author_facet Peng Chiong Tan
May Zaw Soe
Khaing Si Lay
Seok Mui Wang
Shamala Devi Sekaran
Siti Zawiah Omar
author_sort Peng Chiong Tan
title Dengue infection and miscarriage: a prospective case control study.
title_short Dengue infection and miscarriage: a prospective case control study.
title_full Dengue infection and miscarriage: a prospective case control study.
title_fullStr Dengue infection and miscarriage: a prospective case control study.
title_full_unstemmed Dengue infection and miscarriage: a prospective case control study.
title_sort dengue infection and miscarriage: a prospective case control study.
publisher Public Library of Science (PLoS)
publishDate 2012
url https://doi.org/10.1371/journal.pntd.0001637
https://doaj.org/article/940bc228074c46bca1c3fd38c8573b45
geographic Arctic
geographic_facet Arctic
genre Arctic
genre_facet Arctic
op_source PLoS Neglected Tropical Diseases, Vol 6, Iss 5, p e1637 (2012)
op_relation http://europepmc.org/articles/PMC3348154?pdf=render
https://doaj.org/toc/1935-2735
1935-2735
doi:10.1371/journal.pntd.0001637
https://doaj.org/article/940bc228074c46bca1c3fd38c8573b45
op_doi https://doi.org/10.1371/journal.pntd.0001637
container_title PLoS Neglected Tropical Diseases
container_volume 6
container_issue 5
container_start_page e1637
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