Specific features of the lymphocyte enzyme status in newborn infants with the hypotrophic type of intrauterine growth retardation

• Published in: Rossiyskiy Vestnik Perinatologii i Pediatrii (Russian Bulletin of Perinatology and Pediatrics)
• Main Authors: V. P. Novitskaya, V. L. Gritsinskaya
• Format: Article in Journal/Newspaper
• Language: Russian
• Published: Ltd. “The National Academy of Pediatric Science and Innovation” 2016
• Subjects: новорожденные дети; задержка внутриутробного развития; ферменты; лимфоциты; якутия; Pediatrics; RJ1-570; Yakutsk; Yakutia; Якути*; Якутия
• Online Access: https://doi.org/10.21508/1027-4065-2016-61-3-46-50; https://doaj.org/article/93f2e366d0354687bc4294675db44679

Objective: to reveal the specific features of the lymphocyte enzyme status in newborn infants with hypotrophic type of intrauterine growth retardation under the conditions of Yakutia.Subjects and methods. A total of 137 full-term newborns (including 28 babies with intrauterine growth retardation) whose parents were Yakutsk newcomers were examined on 1, 3 and 5 days of life. The cytochemical activity of lymphocyte enzymes, by determining the level of and time course of changes in succinate dehydrogenase (SDH), glycerol-3-phosphate dehydrogenase (GPDH), lactate dehydrogenase (LDH) and its aerobic isoenzyme (LDH-H), NADFH2-diaphorase, monoamine oxidase (MAO), and acid phosphatase (AP), were analyzed.Results. It was ascertained that the activity of SDH, GPDH, and LDH was higher on 5 day of life and that of NADFH2-diaphorase was lower in infants with intrauterine growth retardation than in apparently healthy neonates. Desynchronosis of the metabolic pathways was established in the dynamics of early ontogenesis.Conclusion. It is necessary to rationally correct standard treatment regimens, by taking into account the found metabolic features in infants with intrauterine growth retardation under the conditions of Yakutia.