A new therapeutic approach for bone metastasis in colorectal cancer: intratumoral melittin
Abstract Background: Melittin has shown antiproliferative effects on tumor cells. Therefore, it comprises a valuable compound for studies on cancer treatment. To the best of our knowledge, no studies have reported melittin effects on bone metastasis. Herein, we propose an approach based on intrameta...
Published in: | Journal of Venomous Animals and Toxins including Tropical Diseases |
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Online Access: | https://doi.org/10.1590/1678-9199-jvatitd-2021-0067 https://doaj.org/article/93ddaeb5da834163bdad2a4f218f16c2 |
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ftdoajarticles:oai:doaj.org/article:93ddaeb5da834163bdad2a4f218f16c2 2023-05-15T15:05:02+02:00 A new therapeutic approach for bone metastasis in colorectal cancer: intratumoral melittin Mackson Martins Rocha Isabela Dariva Gabriela Comelli Zornoff Giovanna Sanches De Laurentis Giulia Carli Mendes Maycon Giovani Santana Guilherme Chohfi de Miguel Rui Seabra Ferreira Junior Juliana Mozer Sciani Denise Gonçalves Priolli 2022-03-01T00:00:00Z https://doi.org/10.1590/1678-9199-jvatitd-2021-0067 https://doaj.org/article/93ddaeb5da834163bdad2a4f218f16c2 EN eng SciELO http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992022000100306&tlng=en https://doaj.org/toc/1678-9199 1678-9199 doi:10.1590/1678-9199-jvatitd-2021-0067 https://doaj.org/article/93ddaeb5da834163bdad2a4f218f16c2 Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 28 (2022) Bone metastasis Melittin Intratumoral injection Colorectal neoplasms Bee venom Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 article 2022 ftdoajarticles https://doi.org/10.1590/1678-9199-jvatitd-2021-0067 2022-12-31T04:26:35Z Abstract Background: Melittin has shown antiproliferative effects on tumor cells. Therefore, it comprises a valuable compound for studies on cancer treatment. To the best of our knowledge, no studies have reported melittin effects on bone metastasis. Herein, we propose an approach based on intrametastatic melittin injection to treat bone metastases in colorectal cancer. Methods: Following the characterization of melittin and antiproliferative tests in vitro, a single dose was injected through intrametastatic route into the mouse bone metastasis model. Following treatment, metastasis growth was evaluated. Results: A single dose of melittin was able to inhibit metastasis growth. Histological analysis showed necrosis and inflammatory processes in melittin-treated metastasis. Except by mild weight loss, no other systemic effects were observed. Conclusion: Our data suggest that melittin might be a promising agent for the future development of treatment strategies aiming to reduce the bone metastasis skeletal-related impact in colorectal cancer patients with bone metastasis. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of Venomous Animals and Toxins including Tropical Diseases |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Bone metastasis Melittin Intratumoral injection Colorectal neoplasms Bee venom Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
spellingShingle |
Bone metastasis Melittin Intratumoral injection Colorectal neoplasms Bee venom Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 Mackson Martins Rocha Isabela Dariva Gabriela Comelli Zornoff Giovanna Sanches De Laurentis Giulia Carli Mendes Maycon Giovani Santana Guilherme Chohfi de Miguel Rui Seabra Ferreira Junior Juliana Mozer Sciani Denise Gonçalves Priolli A new therapeutic approach for bone metastasis in colorectal cancer: intratumoral melittin |
topic_facet |
Bone metastasis Melittin Intratumoral injection Colorectal neoplasms Bee venom Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
description |
Abstract Background: Melittin has shown antiproliferative effects on tumor cells. Therefore, it comprises a valuable compound for studies on cancer treatment. To the best of our knowledge, no studies have reported melittin effects on bone metastasis. Herein, we propose an approach based on intrametastatic melittin injection to treat bone metastases in colorectal cancer. Methods: Following the characterization of melittin and antiproliferative tests in vitro, a single dose was injected through intrametastatic route into the mouse bone metastasis model. Following treatment, metastasis growth was evaluated. Results: A single dose of melittin was able to inhibit metastasis growth. Histological analysis showed necrosis and inflammatory processes in melittin-treated metastasis. Except by mild weight loss, no other systemic effects were observed. Conclusion: Our data suggest that melittin might be a promising agent for the future development of treatment strategies aiming to reduce the bone metastasis skeletal-related impact in colorectal cancer patients with bone metastasis. |
format |
Article in Journal/Newspaper |
author |
Mackson Martins Rocha Isabela Dariva Gabriela Comelli Zornoff Giovanna Sanches De Laurentis Giulia Carli Mendes Maycon Giovani Santana Guilherme Chohfi de Miguel Rui Seabra Ferreira Junior Juliana Mozer Sciani Denise Gonçalves Priolli |
author_facet |
Mackson Martins Rocha Isabela Dariva Gabriela Comelli Zornoff Giovanna Sanches De Laurentis Giulia Carli Mendes Maycon Giovani Santana Guilherme Chohfi de Miguel Rui Seabra Ferreira Junior Juliana Mozer Sciani Denise Gonçalves Priolli |
author_sort |
Mackson Martins Rocha |
title |
A new therapeutic approach for bone metastasis in colorectal cancer: intratumoral melittin |
title_short |
A new therapeutic approach for bone metastasis in colorectal cancer: intratumoral melittin |
title_full |
A new therapeutic approach for bone metastasis in colorectal cancer: intratumoral melittin |
title_fullStr |
A new therapeutic approach for bone metastasis in colorectal cancer: intratumoral melittin |
title_full_unstemmed |
A new therapeutic approach for bone metastasis in colorectal cancer: intratumoral melittin |
title_sort |
new therapeutic approach for bone metastasis in colorectal cancer: intratumoral melittin |
publisher |
SciELO |
publishDate |
2022 |
url |
https://doi.org/10.1590/1678-9199-jvatitd-2021-0067 https://doaj.org/article/93ddaeb5da834163bdad2a4f218f16c2 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 28 (2022) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992022000100306&tlng=en https://doaj.org/toc/1678-9199 1678-9199 doi:10.1590/1678-9199-jvatitd-2021-0067 https://doaj.org/article/93ddaeb5da834163bdad2a4f218f16c2 |
op_doi |
https://doi.org/10.1590/1678-9199-jvatitd-2021-0067 |
container_title |
Journal of Venomous Animals and Toxins including Tropical Diseases |
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1766336799278366720 |