The emergence of an imported variant of dengue virus serotype 2 in the Jazan region, southwestern Saudi Arabia
Abstract Background Dengue virus (DENV) infection is a global economic and public health concern, particularly in tropical and subtropical countries where it is endemic. Saudi Arabia has seen an increase in DENV infections, especially in the western and southwestern regions. This study aims to inves...
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ftdoajarticles:oai:doaj.org/article:93b054d717bf45f1a040650ca130cede 2023-05-15T15:11:32+02:00 The emergence of an imported variant of dengue virus serotype 2 in the Jazan region, southwestern Saudi Arabia Ommer Dafalla Ahmed A. Abdulhaq Hatim Almutairi Elsiddig Noureldin Jaber Ghzwani Omar Mashi Khalid J. Shrwani Yahya Hobani Ohood Sufyani Reem Ayed Abdullah Alamri Hesham M. Al-Mekhlafi Zaki M. Eisa 2023-03-01T00:00:00Z https://doi.org/10.1186/s40794-023-00188-8 https://doaj.org/article/93b054d717bf45f1a040650ca130cede EN eng BMC https://doi.org/10.1186/s40794-023-00188-8 https://doaj.org/toc/2055-0936 doi:10.1186/s40794-023-00188-8 2055-0936 https://doaj.org/article/93b054d717bf45f1a040650ca130cede Tropical Diseases, Travel Medicine and Vaccines, Vol 9, Iss 1, Pp 1-9 (2023) Dengue virus Virus evolution Infectious diseases Imported variant Serotype Jazan Arctic medicine. Tropical medicine RC955-962 article 2023 ftdoajarticles https://doi.org/10.1186/s40794-023-00188-8 2023-03-26T01:33:52Z Abstract Background Dengue virus (DENV) infection is a global economic and public health concern, particularly in tropical and subtropical countries where it is endemic. Saudi Arabia has seen an increase in DENV infections, especially in the western and southwestern regions. This study aims to investigate the genetic variants of DENV-2 that were circulating during a serious outbreak in Jazan region in 2019. Methods A total of 482 serum samples collected during 2019 from Jazan region were tested with reverse transcription-polymerase chain reaction (RT-PCR) to detect and classify DENV; positive samples underwent sequencing and bioinformatics analyses. Results Out of 294 positive samples, type-specific RT-PCR identified 58.8% as DENV-2 but could not identify 41.2%. Based on sequencing and bioinformatics analyses, the samples tested PCR positive in the first round but PCR negative in the second round were found to be imported genetic variant of DENV-2. The identified DENV-2 imported variant showed similarities to DENV-2 sequences reported in Malaysia, Singapore, Korea and China. The results revealed the imported genetic variant of DENV-2 was circulating in Jazan region that was highly prevalent and it was likely a major factor in this outbreak. Conclusions The emergence of imported DENV variants is a serious challenge for the dengue fever surveillance and control programmes in endemic areas. Therefore, further investigations and continuous surveillance of existing and new viral strains in the region are warranted. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Tropical Diseases, Travel Medicine and Vaccines 9 1 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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Dengue virus Virus evolution Infectious diseases Imported variant Serotype Jazan Arctic medicine. Tropical medicine RC955-962 |
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Dengue virus Virus evolution Infectious diseases Imported variant Serotype Jazan Arctic medicine. Tropical medicine RC955-962 Ommer Dafalla Ahmed A. Abdulhaq Hatim Almutairi Elsiddig Noureldin Jaber Ghzwani Omar Mashi Khalid J. Shrwani Yahya Hobani Ohood Sufyani Reem Ayed Abdullah Alamri Hesham M. Al-Mekhlafi Zaki M. Eisa The emergence of an imported variant of dengue virus serotype 2 in the Jazan region, southwestern Saudi Arabia |
topic_facet |
Dengue virus Virus evolution Infectious diseases Imported variant Serotype Jazan Arctic medicine. Tropical medicine RC955-962 |
description |
Abstract Background Dengue virus (DENV) infection is a global economic and public health concern, particularly in tropical and subtropical countries where it is endemic. Saudi Arabia has seen an increase in DENV infections, especially in the western and southwestern regions. This study aims to investigate the genetic variants of DENV-2 that were circulating during a serious outbreak in Jazan region in 2019. Methods A total of 482 serum samples collected during 2019 from Jazan region were tested with reverse transcription-polymerase chain reaction (RT-PCR) to detect and classify DENV; positive samples underwent sequencing and bioinformatics analyses. Results Out of 294 positive samples, type-specific RT-PCR identified 58.8% as DENV-2 but could not identify 41.2%. Based on sequencing and bioinformatics analyses, the samples tested PCR positive in the first round but PCR negative in the second round were found to be imported genetic variant of DENV-2. The identified DENV-2 imported variant showed similarities to DENV-2 sequences reported in Malaysia, Singapore, Korea and China. The results revealed the imported genetic variant of DENV-2 was circulating in Jazan region that was highly prevalent and it was likely a major factor in this outbreak. Conclusions The emergence of imported DENV variants is a serious challenge for the dengue fever surveillance and control programmes in endemic areas. Therefore, further investigations and continuous surveillance of existing and new viral strains in the region are warranted. |
format |
Article in Journal/Newspaper |
author |
Ommer Dafalla Ahmed A. Abdulhaq Hatim Almutairi Elsiddig Noureldin Jaber Ghzwani Omar Mashi Khalid J. Shrwani Yahya Hobani Ohood Sufyani Reem Ayed Abdullah Alamri Hesham M. Al-Mekhlafi Zaki M. Eisa |
author_facet |
Ommer Dafalla Ahmed A. Abdulhaq Hatim Almutairi Elsiddig Noureldin Jaber Ghzwani Omar Mashi Khalid J. Shrwani Yahya Hobani Ohood Sufyani Reem Ayed Abdullah Alamri Hesham M. Al-Mekhlafi Zaki M. Eisa |
author_sort |
Ommer Dafalla |
title |
The emergence of an imported variant of dengue virus serotype 2 in the Jazan region, southwestern Saudi Arabia |
title_short |
The emergence of an imported variant of dengue virus serotype 2 in the Jazan region, southwestern Saudi Arabia |
title_full |
The emergence of an imported variant of dengue virus serotype 2 in the Jazan region, southwestern Saudi Arabia |
title_fullStr |
The emergence of an imported variant of dengue virus serotype 2 in the Jazan region, southwestern Saudi Arabia |
title_full_unstemmed |
The emergence of an imported variant of dengue virus serotype 2 in the Jazan region, southwestern Saudi Arabia |
title_sort |
emergence of an imported variant of dengue virus serotype 2 in the jazan region, southwestern saudi arabia |
publisher |
BMC |
publishDate |
2023 |
url |
https://doi.org/10.1186/s40794-023-00188-8 https://doaj.org/article/93b054d717bf45f1a040650ca130cede |
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Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Tropical Diseases, Travel Medicine and Vaccines, Vol 9, Iss 1, Pp 1-9 (2023) |
op_relation |
https://doi.org/10.1186/s40794-023-00188-8 https://doaj.org/toc/2055-0936 doi:10.1186/s40794-023-00188-8 2055-0936 https://doaj.org/article/93b054d717bf45f1a040650ca130cede |
op_doi |
https://doi.org/10.1186/s40794-023-00188-8 |
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Tropical Diseases, Travel Medicine and Vaccines |
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9 |
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1 |
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