Comparative Analysis of the Blood Plasma Metabolome of Negligible, Gradual and Rapidly Ageing Fishes
There are a number of different animals that belong to long- and short-lived species and show a various rate of ageing, providing an ideal model to investigate mechanisms of longevity. In this work, a metabolome profiling of blood plasma from fishes with various ageing rates—negligible (Pike Esox Lu...
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ftdoajarticles:oai:doaj.org/article:938e8d9bcebf473ca2a025eb95e11d43 2023-05-15T17:52:51+02:00 Comparative Analysis of the Blood Plasma Metabolome of Negligible, Gradual and Rapidly Ageing Fishes Oxana P. Trifonova Dmitry L. Maslov Anton N. Mikhailov Konstantin V. Zolotarev Kirill V. Nakhod Valeriya I. Nakhod Nataliya F. Belyaeva Marina V. Mikhailova Petr G. Lokhov Alexander I. Archakov 2018-12-01T00:00:00Z https://doi.org/10.3390/fishes3040046 https://doaj.org/article/938e8d9bcebf473ca2a025eb95e11d43 EN eng MDPI AG https://www.mdpi.com/2410-3888/3/4/46 https://doaj.org/toc/2410-3888 2410-3888 doi:10.3390/fishes3040046 https://doaj.org/article/938e8d9bcebf473ca2a025eb95e11d43 Fishes, Vol 3, Iss 4, Pp 46-0 (2018) fish ageing blood plasma metabolites metabolome profiling type of senescence negligible ageing Biology (General) QH301-705.5 Genetics QH426-470 article 2018 ftdoajarticles https://doi.org/10.3390/fishes3040046 2022-12-31T11:47:32Z There are a number of different animals that belong to long- and short-lived species and show a various rate of ageing, providing an ideal model to investigate mechanisms of longevity. In this work, a metabolome profiling of blood plasma from fishes with various ageing rates—negligible (Pike Esox Lucius and Sterlet Acipenser ruthenus ), gradual (Zander Sander lucioperca and Perch Perca fluviatilis ) and rapid (Chum Salmon Oncorhynchus keta and Pink Salmon Oncorhynchus gorbuscha )—was assessed by means of direct infusion to quadrupole time-of-flight mass spectrometry. Of the 2056 distinct m/z features detected by a mass spectrometry metabolic profiling of blood plasma samples, fifteen metabolites in the classes of dipeptides, fatty acids, glycerolipids, phosphoethanolamines and phosphatidylcholines were significantly associated with ageing rate, independent of species differences. This is the first study of the metabolome of fishes with various ageing rate, and this untargeted approach highlighted the metabolic conditions that may serve to assess the ageing process. Article in Journal/Newspaper Oncorhynchus gorbuscha Pink salmon Directory of Open Access Journals: DOAJ Articles Keta ENVELOPE(-19.455,-19.455,65.656,65.656) Fishes 3 4 46 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
fish ageing blood plasma metabolites metabolome profiling type of senescence negligible ageing Biology (General) QH301-705.5 Genetics QH426-470 |
spellingShingle |
fish ageing blood plasma metabolites metabolome profiling type of senescence negligible ageing Biology (General) QH301-705.5 Genetics QH426-470 Oxana P. Trifonova Dmitry L. Maslov Anton N. Mikhailov Konstantin V. Zolotarev Kirill V. Nakhod Valeriya I. Nakhod Nataliya F. Belyaeva Marina V. Mikhailova Petr G. Lokhov Alexander I. Archakov Comparative Analysis of the Blood Plasma Metabolome of Negligible, Gradual and Rapidly Ageing Fishes |
topic_facet |
fish ageing blood plasma metabolites metabolome profiling type of senescence negligible ageing Biology (General) QH301-705.5 Genetics QH426-470 |
description |
There are a number of different animals that belong to long- and short-lived species and show a various rate of ageing, providing an ideal model to investigate mechanisms of longevity. In this work, a metabolome profiling of blood plasma from fishes with various ageing rates—negligible (Pike Esox Lucius and Sterlet Acipenser ruthenus ), gradual (Zander Sander lucioperca and Perch Perca fluviatilis ) and rapid (Chum Salmon Oncorhynchus keta and Pink Salmon Oncorhynchus gorbuscha )—was assessed by means of direct infusion to quadrupole time-of-flight mass spectrometry. Of the 2056 distinct m/z features detected by a mass spectrometry metabolic profiling of blood plasma samples, fifteen metabolites in the classes of dipeptides, fatty acids, glycerolipids, phosphoethanolamines and phosphatidylcholines were significantly associated with ageing rate, independent of species differences. This is the first study of the metabolome of fishes with various ageing rate, and this untargeted approach highlighted the metabolic conditions that may serve to assess the ageing process. |
format |
Article in Journal/Newspaper |
author |
Oxana P. Trifonova Dmitry L. Maslov Anton N. Mikhailov Konstantin V. Zolotarev Kirill V. Nakhod Valeriya I. Nakhod Nataliya F. Belyaeva Marina V. Mikhailova Petr G. Lokhov Alexander I. Archakov |
author_facet |
Oxana P. Trifonova Dmitry L. Maslov Anton N. Mikhailov Konstantin V. Zolotarev Kirill V. Nakhod Valeriya I. Nakhod Nataliya F. Belyaeva Marina V. Mikhailova Petr G. Lokhov Alexander I. Archakov |
author_sort |
Oxana P. Trifonova |
title |
Comparative Analysis of the Blood Plasma Metabolome of Negligible, Gradual and Rapidly Ageing Fishes |
title_short |
Comparative Analysis of the Blood Plasma Metabolome of Negligible, Gradual and Rapidly Ageing Fishes |
title_full |
Comparative Analysis of the Blood Plasma Metabolome of Negligible, Gradual and Rapidly Ageing Fishes |
title_fullStr |
Comparative Analysis of the Blood Plasma Metabolome of Negligible, Gradual and Rapidly Ageing Fishes |
title_full_unstemmed |
Comparative Analysis of the Blood Plasma Metabolome of Negligible, Gradual and Rapidly Ageing Fishes |
title_sort |
comparative analysis of the blood plasma metabolome of negligible, gradual and rapidly ageing fishes |
publisher |
MDPI AG |
publishDate |
2018 |
url |
https://doi.org/10.3390/fishes3040046 https://doaj.org/article/938e8d9bcebf473ca2a025eb95e11d43 |
long_lat |
ENVELOPE(-19.455,-19.455,65.656,65.656) |
geographic |
Keta |
geographic_facet |
Keta |
genre |
Oncorhynchus gorbuscha Pink salmon |
genre_facet |
Oncorhynchus gorbuscha Pink salmon |
op_source |
Fishes, Vol 3, Iss 4, Pp 46-0 (2018) |
op_relation |
https://www.mdpi.com/2410-3888/3/4/46 https://doaj.org/toc/2410-3888 2410-3888 doi:10.3390/fishes3040046 https://doaj.org/article/938e8d9bcebf473ca2a025eb95e11d43 |
op_doi |
https://doi.org/10.3390/fishes3040046 |
container_title |
Fishes |
container_volume |
3 |
container_issue |
4 |
container_start_page |
46 |
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1766160589295452160 |