Understanding the complexity of Tityus serrulatus venom: A focus on high molecular weight components
Abstract Tityus serrulatus scorpion is responsible for a significant number of envenomings in Brazil, ranging from mild to severe, and in some cases, leading to fatalities. While supportive care is the primary treatment modality, moderate and severe cases require antivenom administration despite pot...
Published in: | Journal of Venomous Animals and Toxins including Tropical Diseases |
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ftdoajarticles:oai:doaj.org/article:9351dc123552445eb297ce246d3aae49 2024-02-27T08:38:11+00:00 Understanding the complexity of Tityus serrulatus venom: A focus on high molecular weight components Isadora Sousa de Oliveira Nicoly Malachize Alano-da-Silva Isabela Gobbo Ferreira Felipe Augusto Cerni Jacqueline de Almeida Gonçalves Sachett Wuelton Marcelo Monteiro Manuela Berto Pucca Eliane Candiani Arantes 2024-01-01T00:00:00Z https://doi.org/10.1590/1678-9199-jvatitd-2023-0046 https://doaj.org/article/9351dc123552445eb297ce246d3aae49 EN eng SciELO http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992024000100201&lng=en&tlng=en http://www.scielo.br/pdf/jvatitd/v30/1678-9199-jvatitd-30-e20230046.pdf https://doaj.org/toc/1678-9199 1678-9199 doi:10.1590/1678-9199-jvatitd-2023-0046 https://doaj.org/article/9351dc123552445eb297ce246d3aae49 Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 30 (2024) Tityus serrulatus Proteases Hyaluronidase Phospholipase Cysteine-rich secretory proteins Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 article 2024 ftdoajarticles https://doi.org/10.1590/1678-9199-jvatitd-2023-0046 2024-01-28T02:16:28Z Abstract Tityus serrulatus scorpion is responsible for a significant number of envenomings in Brazil, ranging from mild to severe, and in some cases, leading to fatalities. While supportive care is the primary treatment modality, moderate and severe cases require antivenom administration despite potential limitations and adverse effects. The remarkable proliferation of T. serrulatus scorpions, attributed to their biology and asexual reproduction, contributes to a high incidence of envenomation. T. serrulatus scorpion venom predominantly consists of short proteins acting as neurotoxins (α and β), that primarily target ion channels. Nevertheless, high molecular weight compounds, including metalloproteases, serine proteases, phospholipases, and hyaluronidases, are also present in the venom. These compounds play a crucial role in envenomation, influencing the severity of symptoms and the spread of venom. This review endeavors to comprehensively understand the T. serrulatus scorpion venom by elucidating the primary high molecular weight compounds and exploring their potential contributions to envenomation. Understanding these compounds' mechanisms of action can aid in developing more effective treatments and prevention strategies, ultimately mitigating the impact of scorpion envenomation on public health in Brazil. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of Venomous Animals and Toxins including Tropical Diseases 30 |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Tityus serrulatus Proteases Hyaluronidase Phospholipase Cysteine-rich secretory proteins Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
spellingShingle |
Tityus serrulatus Proteases Hyaluronidase Phospholipase Cysteine-rich secretory proteins Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 Isadora Sousa de Oliveira Nicoly Malachize Alano-da-Silva Isabela Gobbo Ferreira Felipe Augusto Cerni Jacqueline de Almeida Gonçalves Sachett Wuelton Marcelo Monteiro Manuela Berto Pucca Eliane Candiani Arantes Understanding the complexity of Tityus serrulatus venom: A focus on high molecular weight components |
topic_facet |
Tityus serrulatus Proteases Hyaluronidase Phospholipase Cysteine-rich secretory proteins Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
description |
Abstract Tityus serrulatus scorpion is responsible for a significant number of envenomings in Brazil, ranging from mild to severe, and in some cases, leading to fatalities. While supportive care is the primary treatment modality, moderate and severe cases require antivenom administration despite potential limitations and adverse effects. The remarkable proliferation of T. serrulatus scorpions, attributed to their biology and asexual reproduction, contributes to a high incidence of envenomation. T. serrulatus scorpion venom predominantly consists of short proteins acting as neurotoxins (α and β), that primarily target ion channels. Nevertheless, high molecular weight compounds, including metalloproteases, serine proteases, phospholipases, and hyaluronidases, are also present in the venom. These compounds play a crucial role in envenomation, influencing the severity of symptoms and the spread of venom. This review endeavors to comprehensively understand the T. serrulatus scorpion venom by elucidating the primary high molecular weight compounds and exploring their potential contributions to envenomation. Understanding these compounds' mechanisms of action can aid in developing more effective treatments and prevention strategies, ultimately mitigating the impact of scorpion envenomation on public health in Brazil. |
format |
Article in Journal/Newspaper |
author |
Isadora Sousa de Oliveira Nicoly Malachize Alano-da-Silva Isabela Gobbo Ferreira Felipe Augusto Cerni Jacqueline de Almeida Gonçalves Sachett Wuelton Marcelo Monteiro Manuela Berto Pucca Eliane Candiani Arantes |
author_facet |
Isadora Sousa de Oliveira Nicoly Malachize Alano-da-Silva Isabela Gobbo Ferreira Felipe Augusto Cerni Jacqueline de Almeida Gonçalves Sachett Wuelton Marcelo Monteiro Manuela Berto Pucca Eliane Candiani Arantes |
author_sort |
Isadora Sousa de Oliveira |
title |
Understanding the complexity of Tityus serrulatus venom: A focus on high molecular weight components |
title_short |
Understanding the complexity of Tityus serrulatus venom: A focus on high molecular weight components |
title_full |
Understanding the complexity of Tityus serrulatus venom: A focus on high molecular weight components |
title_fullStr |
Understanding the complexity of Tityus serrulatus venom: A focus on high molecular weight components |
title_full_unstemmed |
Understanding the complexity of Tityus serrulatus venom: A focus on high molecular weight components |
title_sort |
understanding the complexity of tityus serrulatus venom: a focus on high molecular weight components |
publisher |
SciELO |
publishDate |
2024 |
url |
https://doi.org/10.1590/1678-9199-jvatitd-2023-0046 https://doaj.org/article/9351dc123552445eb297ce246d3aae49 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 30 (2024) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992024000100201&lng=en&tlng=en http://www.scielo.br/pdf/jvatitd/v30/1678-9199-jvatitd-30-e20230046.pdf https://doaj.org/toc/1678-9199 1678-9199 doi:10.1590/1678-9199-jvatitd-2023-0046 https://doaj.org/article/9351dc123552445eb297ce246d3aae49 |
op_doi |
https://doi.org/10.1590/1678-9199-jvatitd-2023-0046 |
container_title |
Journal of Venomous Animals and Toxins including Tropical Diseases |
container_volume |
30 |
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1792045118320017408 |