Global transcriptional analysis of short-term hepatic stress responses in Atlantic salmon (Salmo salar) exposed to depleted uranium
Potential environmental hazards of radionuclides are often studied at the individual level. Sufficient toxicogenomics data at the molecular/cellular level for understanding the effects and modes of toxic action (MoAs) of radionuclide is still lacking. The current article introduces transcriptomic da...
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ftdoajarticles:oai:doaj.org/article:934d35c0740d401bbddb46486ddd21b9 2023-05-15T15:30:21+02:00 Global transcriptional analysis of short-term hepatic stress responses in Atlantic salmon (Salmo salar) exposed to depleted uranium You Song Brit Salbu Hans-Christian Teien Lene Sørlie Heier Bjørn Olav Rosseland Tore Høgåsen Knut Erik Tollefsen 2014-12-01T00:00:00Z https://doi.org/10.1016/j.gdata.2014.10.003 https://doaj.org/article/934d35c0740d401bbddb46486ddd21b9 EN eng Elsevier http://www.sciencedirect.com/science/article/pii/S2213596014000907 https://doaj.org/toc/2213-5960 2213-5960 doi:10.1016/j.gdata.2014.10.003 https://doaj.org/article/934d35c0740d401bbddb46486ddd21b9 Genomics Data, Vol 2, Iss C, Pp 340-341 (2014) Atlantic salmon Depleted uranium Microarray Gene expression Stress response Genetics QH426-470 article 2014 ftdoajarticles https://doi.org/10.1016/j.gdata.2014.10.003 2022-12-31T14:46:35Z Potential environmental hazards of radionuclides are often studied at the individual level. Sufficient toxicogenomics data at the molecular/cellular level for understanding the effects and modes of toxic action (MoAs) of radionuclide is still lacking. The current article introduces transcriptomic data generated from a recent ecotoxicological study, with the aims to characterize the MoAs of a metallic radionuclide, deplete uranium (DU) in an ecologically and commercially important fish species, Atlantic salmon (Salmo salar). Salmon were exposed to three concentrations (0.25, 0.5 and 1.0 mg/L) of DU for 48 h. Short-term global transcriptional responses were studied using Agilent custom-designed high density 60,000-feature (60 k) salmonid oligonucleotide microarrays (oligoarray). The microarray datasets deposited at Gene Expression Omnibus (GEO ID: GSE58824) were associated with a recently published study by Song et al. (2014) in BMC Genomics. The authors describe the experimental data herein to build a platform for better understanding the toxic mechanisms and ecological hazard of radionuclides such as DU in fish. Article in Journal/Newspaper Atlantic salmon Salmo salar Directory of Open Access Journals: DOAJ Articles Genomics Data 2 340 341 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Atlantic salmon Depleted uranium Microarray Gene expression Stress response Genetics QH426-470 |
spellingShingle |
Atlantic salmon Depleted uranium Microarray Gene expression Stress response Genetics QH426-470 You Song Brit Salbu Hans-Christian Teien Lene Sørlie Heier Bjørn Olav Rosseland Tore Høgåsen Knut Erik Tollefsen Global transcriptional analysis of short-term hepatic stress responses in Atlantic salmon (Salmo salar) exposed to depleted uranium |
topic_facet |
Atlantic salmon Depleted uranium Microarray Gene expression Stress response Genetics QH426-470 |
description |
Potential environmental hazards of radionuclides are often studied at the individual level. Sufficient toxicogenomics data at the molecular/cellular level for understanding the effects and modes of toxic action (MoAs) of radionuclide is still lacking. The current article introduces transcriptomic data generated from a recent ecotoxicological study, with the aims to characterize the MoAs of a metallic radionuclide, deplete uranium (DU) in an ecologically and commercially important fish species, Atlantic salmon (Salmo salar). Salmon were exposed to three concentrations (0.25, 0.5 and 1.0 mg/L) of DU for 48 h. Short-term global transcriptional responses were studied using Agilent custom-designed high density 60,000-feature (60 k) salmonid oligonucleotide microarrays (oligoarray). The microarray datasets deposited at Gene Expression Omnibus (GEO ID: GSE58824) were associated with a recently published study by Song et al. (2014) in BMC Genomics. The authors describe the experimental data herein to build a platform for better understanding the toxic mechanisms and ecological hazard of radionuclides such as DU in fish. |
format |
Article in Journal/Newspaper |
author |
You Song Brit Salbu Hans-Christian Teien Lene Sørlie Heier Bjørn Olav Rosseland Tore Høgåsen Knut Erik Tollefsen |
author_facet |
You Song Brit Salbu Hans-Christian Teien Lene Sørlie Heier Bjørn Olav Rosseland Tore Høgåsen Knut Erik Tollefsen |
author_sort |
You Song |
title |
Global transcriptional analysis of short-term hepatic stress responses in Atlantic salmon (Salmo salar) exposed to depleted uranium |
title_short |
Global transcriptional analysis of short-term hepatic stress responses in Atlantic salmon (Salmo salar) exposed to depleted uranium |
title_full |
Global transcriptional analysis of short-term hepatic stress responses in Atlantic salmon (Salmo salar) exposed to depleted uranium |
title_fullStr |
Global transcriptional analysis of short-term hepatic stress responses in Atlantic salmon (Salmo salar) exposed to depleted uranium |
title_full_unstemmed |
Global transcriptional analysis of short-term hepatic stress responses in Atlantic salmon (Salmo salar) exposed to depleted uranium |
title_sort |
global transcriptional analysis of short-term hepatic stress responses in atlantic salmon (salmo salar) exposed to depleted uranium |
publisher |
Elsevier |
publishDate |
2014 |
url |
https://doi.org/10.1016/j.gdata.2014.10.003 https://doaj.org/article/934d35c0740d401bbddb46486ddd21b9 |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_source |
Genomics Data, Vol 2, Iss C, Pp 340-341 (2014) |
op_relation |
http://www.sciencedirect.com/science/article/pii/S2213596014000907 https://doaj.org/toc/2213-5960 2213-5960 doi:10.1016/j.gdata.2014.10.003 https://doaj.org/article/934d35c0740d401bbddb46486ddd21b9 |
op_doi |
https://doi.org/10.1016/j.gdata.2014.10.003 |
container_title |
Genomics Data |
container_volume |
2 |
container_start_page |
340 |
op_container_end_page |
341 |
_version_ |
1766360799185469440 |