Associations between red blood cell variants and malaria among children and adults from three areas of Uganda: a prospective cohort study
Abstract Background Multiple red blood cell (RBC) variants appear to offer protection against the most severe forms of Plasmodium falciparum malaria. Associations between these variants and uncomplicated malaria are less clear. Methods Data from a longitudinal cohort study conducted in 3 sub-countie...
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ftdoajarticles:oai:doaj.org/article:93362740cd014f2ba10ab93bf00a672e 2023-05-15T15:15:18+02:00 Associations between red blood cell variants and malaria among children and adults from three areas of Uganda: a prospective cohort study Elijah Kakande Bryan Greenhouse Francis Bajunirwe Chris Drakeley Joaniter I. Nankabirwa Andrew Walakira Samuel L. Nsobya Agaba Katureebe John Rek Emmanuel Arinaitwe Philip J. Rosenthal Moses R. Kamya Grant Dorsey Isabel Rodriguez-Barraquer 2020-01-01T00:00:00Z https://doi.org/10.1186/s12936-020-3105-3 https://doaj.org/article/93362740cd014f2ba10ab93bf00a672e EN eng BMC https://doi.org/10.1186/s12936-020-3105-3 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-020-3105-3 1475-2875 https://doaj.org/article/93362740cd014f2ba10ab93bf00a672e Malaria Journal, Vol 19, Iss 1, Pp 1-9 (2020) Red blood cell variants Erythrocyte Malaria Plasmodium Sickle hemoglobin Thalassemia Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2020 ftdoajarticles https://doi.org/10.1186/s12936-020-3105-3 2022-12-31T12:06:54Z Abstract Background Multiple red blood cell (RBC) variants appear to offer protection against the most severe forms of Plasmodium falciparum malaria. Associations between these variants and uncomplicated malaria are less clear. Methods Data from a longitudinal cohort study conducted in 3 sub-counties in Uganda was used to quantify associations between three red blood cell variants Hb [AA, AS, S (rs334)], alpha thalassaemia 3.7 kb deletion, and glucose-6-phosphate dehydrogenase deficiency A—(G6PD 202A genotype) and malaria incidence, parasite prevalence, parasite density (a measure of anti-parasite immunity) and body temperature adjusted for parasite density (a measure of anti-disease immunity). All analyses were adjusted for age, average household entomological inoculation rate, and study site. Results for all variants were compared to those for wild type genotypes. Results In children, HbAS was associated, compared to wild type, with a lower incidence of malaria (IRR = 0.78, 95% CI 0.66–0.92, p = 0.003), lower parasite density upon infection (PR = 0.66, 95% CI 0.51–0.85, p = 0.001), and lower body temperature for any given parasite density (− 0.13 ℃, 95% CI − 0.21, − 0.05, p = 0.002). In children, HbSS was associated with a lower incidence of malaria (IRR = 0.17, 95% CI 0.04–0.71, p = 0.02) and lower parasite density upon infection (PR = 0.31, 95% CI 0.18–0.54, p < 0.001). α−/αα thalassaemia, was associated with higher parasite prevalence in both children and adults (RR = 1.23, 95% CI 1.06–1.43, p = 0.008 and RR = 1.52, 95% CI 1.04–2.23, p = 0.03, respectively). G6PD deficiency was associated with lower body temperature for any given parasite density only among male hemizygote children (− 0.19 ℃, 95% CI − 0.31, − 0.06, p = 0.003). Conclusion RBC variants were associated with non-severe malaria outcomes. Elucidation of the mechanisms by which they confer protection will improve understanding of genetic protection against malaria. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Sickle ENVELOPE(-66.783,-66.783,-68.867,-68.867) Malaria Journal 19 1 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Red blood cell variants Erythrocyte Malaria Plasmodium Sickle hemoglobin Thalassemia Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Red blood cell variants Erythrocyte Malaria Plasmodium Sickle hemoglobin Thalassemia Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Elijah Kakande Bryan Greenhouse Francis Bajunirwe Chris Drakeley Joaniter I. Nankabirwa Andrew Walakira Samuel L. Nsobya Agaba Katureebe John Rek Emmanuel Arinaitwe Philip J. Rosenthal Moses R. Kamya Grant Dorsey Isabel Rodriguez-Barraquer Associations between red blood cell variants and malaria among children and adults from three areas of Uganda: a prospective cohort study |
topic_facet |
Red blood cell variants Erythrocyte Malaria Plasmodium Sickle hemoglobin Thalassemia Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Multiple red blood cell (RBC) variants appear to offer protection against the most severe forms of Plasmodium falciparum malaria. Associations between these variants and uncomplicated malaria are less clear. Methods Data from a longitudinal cohort study conducted in 3 sub-counties in Uganda was used to quantify associations between three red blood cell variants Hb [AA, AS, S (rs334)], alpha thalassaemia 3.7 kb deletion, and glucose-6-phosphate dehydrogenase deficiency A—(G6PD 202A genotype) and malaria incidence, parasite prevalence, parasite density (a measure of anti-parasite immunity) and body temperature adjusted for parasite density (a measure of anti-disease immunity). All analyses were adjusted for age, average household entomological inoculation rate, and study site. Results for all variants were compared to those for wild type genotypes. Results In children, HbAS was associated, compared to wild type, with a lower incidence of malaria (IRR = 0.78, 95% CI 0.66–0.92, p = 0.003), lower parasite density upon infection (PR = 0.66, 95% CI 0.51–0.85, p = 0.001), and lower body temperature for any given parasite density (− 0.13 ℃, 95% CI − 0.21, − 0.05, p = 0.002). In children, HbSS was associated with a lower incidence of malaria (IRR = 0.17, 95% CI 0.04–0.71, p = 0.02) and lower parasite density upon infection (PR = 0.31, 95% CI 0.18–0.54, p < 0.001). α−/αα thalassaemia, was associated with higher parasite prevalence in both children and adults (RR = 1.23, 95% CI 1.06–1.43, p = 0.008 and RR = 1.52, 95% CI 1.04–2.23, p = 0.03, respectively). G6PD deficiency was associated with lower body temperature for any given parasite density only among male hemizygote children (− 0.19 ℃, 95% CI − 0.31, − 0.06, p = 0.003). Conclusion RBC variants were associated with non-severe malaria outcomes. Elucidation of the mechanisms by which they confer protection will improve understanding of genetic protection against malaria. |
format |
Article in Journal/Newspaper |
author |
Elijah Kakande Bryan Greenhouse Francis Bajunirwe Chris Drakeley Joaniter I. Nankabirwa Andrew Walakira Samuel L. Nsobya Agaba Katureebe John Rek Emmanuel Arinaitwe Philip J. Rosenthal Moses R. Kamya Grant Dorsey Isabel Rodriguez-Barraquer |
author_facet |
Elijah Kakande Bryan Greenhouse Francis Bajunirwe Chris Drakeley Joaniter I. Nankabirwa Andrew Walakira Samuel L. Nsobya Agaba Katureebe John Rek Emmanuel Arinaitwe Philip J. Rosenthal Moses R. Kamya Grant Dorsey Isabel Rodriguez-Barraquer |
author_sort |
Elijah Kakande |
title |
Associations between red blood cell variants and malaria among children and adults from three areas of Uganda: a prospective cohort study |
title_short |
Associations between red blood cell variants and malaria among children and adults from three areas of Uganda: a prospective cohort study |
title_full |
Associations between red blood cell variants and malaria among children and adults from three areas of Uganda: a prospective cohort study |
title_fullStr |
Associations between red blood cell variants and malaria among children and adults from three areas of Uganda: a prospective cohort study |
title_full_unstemmed |
Associations between red blood cell variants and malaria among children and adults from three areas of Uganda: a prospective cohort study |
title_sort |
associations between red blood cell variants and malaria among children and adults from three areas of uganda: a prospective cohort study |
publisher |
BMC |
publishDate |
2020 |
url |
https://doi.org/10.1186/s12936-020-3105-3 https://doaj.org/article/93362740cd014f2ba10ab93bf00a672e |
long_lat |
ENVELOPE(-66.783,-66.783,-68.867,-68.867) |
geographic |
Arctic Sickle |
geographic_facet |
Arctic Sickle |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 19, Iss 1, Pp 1-9 (2020) |
op_relation |
https://doi.org/10.1186/s12936-020-3105-3 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-020-3105-3 1475-2875 https://doaj.org/article/93362740cd014f2ba10ab93bf00a672e |
op_doi |
https://doi.org/10.1186/s12936-020-3105-3 |
container_title |
Malaria Journal |
container_volume |
19 |
container_issue |
1 |
_version_ |
1766345670463062016 |