Pyrethroid susceptibility reversal in Aedes aegypti: A longitudinal study in Tapachula, Mexico.
Pyrethroid resistance in Aedes aegypti has become widespread after almost two decades of frequent applications to reduce the transmission of mosquito-borne diseases. Because few insecticide classes are available for public health use, insecticide resistance management (IRM) is proposed as a strategy...
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ftdoajarticles:oai:doaj.org/article:93035cbeeaf1485faa544d4c9140ec57 2024-09-09T19:27:31+00:00 Pyrethroid susceptibility reversal in Aedes aegypti: A longitudinal study in Tapachula, Mexico. Patricia Penilla-Navarro Francisco Solis-Santoyo Alma Lopez-Solis Americo D Rodriguez Farah Vera-Maloof Saul Lozano Elsa Contreras-Mejía Geovanni Vázquez-Samayoa Rene Torreblanca-Lopez Rushika Perera William C Black Iv Karla Saavedra-Rodriguez 2024-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0011369 https://doaj.org/article/93035cbeeaf1485faa544d4c9140ec57 EN eng Public Library of Science (PLoS) https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0011369&type=printable https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0011369 https://doaj.org/article/93035cbeeaf1485faa544d4c9140ec57 PLoS Neglected Tropical Diseases, Vol 18, Iss 1, p e0011369 (2024) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2024 ftdoajarticles https://doi.org/10.1371/journal.pntd.0011369 2024-08-05T17:50:02Z Pyrethroid resistance in Aedes aegypti has become widespread after almost two decades of frequent applications to reduce the transmission of mosquito-borne diseases. Because few insecticide classes are available for public health use, insecticide resistance management (IRM) is proposed as a strategy to retain their use. A key hypothesis of IRM assumes that negative fitness is associated with resistance, and when insecticides are removed from use, susceptibility is restored. In Tapachula, Mexico, pyrethroids (PYRs) were used exclusively by dengue control programs for 15 years, thereby contributing to selection for high PYR resistance in mosquitoes and failure in dengue control. In 2013, PYRs were replaced by organophosphates-insecticides from a class with a different mode of action. To test the hypothesis that PYR resistance is reversed in the absence of PYRs, we monitored Ae. aegypti's PYR resistance from 2016 to 2021 in Tapachula. We observed significant declining rates in the lethal concentration 50 (LC50), for permethrin and deltamethrin. For each month following the discontinuation of PYR use by vector control programs, we observed increases in the odds of mosquitoes dying by 1.5% and 8.4% for permethrin and deltamethrin, respectively. Also, knockdown-resistance mutations (kdr) in the voltage-gated sodium channel explained the variation in the permethrin LC50s, whereas variation in the deltamethrin LC50s was only explained by time. This trend was rapidly offset by application of a mixture of neonicotinoid and PYRs by vector control programs. Our results suggest that IRM strategies can be used to reverse PYR resistance in Ae. aegypti; however, long-term commitment by operational and community programs will be required for success. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 18 1 e0011369 |
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Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Patricia Penilla-Navarro Francisco Solis-Santoyo Alma Lopez-Solis Americo D Rodriguez Farah Vera-Maloof Saul Lozano Elsa Contreras-Mejía Geovanni Vázquez-Samayoa Rene Torreblanca-Lopez Rushika Perera William C Black Iv Karla Saavedra-Rodriguez Pyrethroid susceptibility reversal in Aedes aegypti: A longitudinal study in Tapachula, Mexico. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Pyrethroid resistance in Aedes aegypti has become widespread after almost two decades of frequent applications to reduce the transmission of mosquito-borne diseases. Because few insecticide classes are available for public health use, insecticide resistance management (IRM) is proposed as a strategy to retain their use. A key hypothesis of IRM assumes that negative fitness is associated with resistance, and when insecticides are removed from use, susceptibility is restored. In Tapachula, Mexico, pyrethroids (PYRs) were used exclusively by dengue control programs for 15 years, thereby contributing to selection for high PYR resistance in mosquitoes and failure in dengue control. In 2013, PYRs were replaced by organophosphates-insecticides from a class with a different mode of action. To test the hypothesis that PYR resistance is reversed in the absence of PYRs, we monitored Ae. aegypti's PYR resistance from 2016 to 2021 in Tapachula. We observed significant declining rates in the lethal concentration 50 (LC50), for permethrin and deltamethrin. For each month following the discontinuation of PYR use by vector control programs, we observed increases in the odds of mosquitoes dying by 1.5% and 8.4% for permethrin and deltamethrin, respectively. Also, knockdown-resistance mutations (kdr) in the voltage-gated sodium channel explained the variation in the permethrin LC50s, whereas variation in the deltamethrin LC50s was only explained by time. This trend was rapidly offset by application of a mixture of neonicotinoid and PYRs by vector control programs. Our results suggest that IRM strategies can be used to reverse PYR resistance in Ae. aegypti; however, long-term commitment by operational and community programs will be required for success. |
format |
Article in Journal/Newspaper |
author |
Patricia Penilla-Navarro Francisco Solis-Santoyo Alma Lopez-Solis Americo D Rodriguez Farah Vera-Maloof Saul Lozano Elsa Contreras-Mejía Geovanni Vázquez-Samayoa Rene Torreblanca-Lopez Rushika Perera William C Black Iv Karla Saavedra-Rodriguez |
author_facet |
Patricia Penilla-Navarro Francisco Solis-Santoyo Alma Lopez-Solis Americo D Rodriguez Farah Vera-Maloof Saul Lozano Elsa Contreras-Mejía Geovanni Vázquez-Samayoa Rene Torreblanca-Lopez Rushika Perera William C Black Iv Karla Saavedra-Rodriguez |
author_sort |
Patricia Penilla-Navarro |
title |
Pyrethroid susceptibility reversal in Aedes aegypti: A longitudinal study in Tapachula, Mexico. |
title_short |
Pyrethroid susceptibility reversal in Aedes aegypti: A longitudinal study in Tapachula, Mexico. |
title_full |
Pyrethroid susceptibility reversal in Aedes aegypti: A longitudinal study in Tapachula, Mexico. |
title_fullStr |
Pyrethroid susceptibility reversal in Aedes aegypti: A longitudinal study in Tapachula, Mexico. |
title_full_unstemmed |
Pyrethroid susceptibility reversal in Aedes aegypti: A longitudinal study in Tapachula, Mexico. |
title_sort |
pyrethroid susceptibility reversal in aedes aegypti: a longitudinal study in tapachula, mexico. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2024 |
url |
https://doi.org/10.1371/journal.pntd.0011369 https://doaj.org/article/93035cbeeaf1485faa544d4c9140ec57 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 18, Iss 1, p e0011369 (2024) |
op_relation |
https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0011369&type=printable https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0011369 https://doaj.org/article/93035cbeeaf1485faa544d4c9140ec57 |
op_doi |
https://doi.org/10.1371/journal.pntd.0011369 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
18 |
container_issue |
1 |
container_start_page |
e0011369 |
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1809896946745212928 |