The impact of human reservoir of malaria at a community-level on individual malaria occurrence in a low malaria transmission setting along the Thai-Myanmar border
Abstract Background The probability of contracting malaria in a given individual is determined not only by the individual's characteristics, but also the ecological factors that characterize the level of human-vector contact in the population. Examination of the relationship between "indiv...
Published in: | Malaria Journal |
---|---|
Main Authors: | , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
BMC
2010
|
Subjects: | |
Online Access: | https://doi.org/10.1186/1475-2875-9-143 https://doaj.org/article/92ef410d54254d0fb1ab7933dd13c86e |
id |
ftdoajarticles:oai:doaj.org/article:92ef410d54254d0fb1ab7933dd13c86e |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:92ef410d54254d0fb1ab7933dd13c86e 2023-05-15T15:15:03+02:00 The impact of human reservoir of malaria at a community-level on individual malaria occurrence in a low malaria transmission setting along the Thai-Myanmar border Chaimungkun Wuthichai Maneeboonyang Wanchai Thanyavanich Nipon Puangsa-art Supalap Yimsamran Surapon Chavez Irwin F Lawpoolsri Saranath Singhasivanon Pratap Maguire James H Hungerford Laura L 2010-05-01T00:00:00Z https://doi.org/10.1186/1475-2875-9-143 https://doaj.org/article/92ef410d54254d0fb1ab7933dd13c86e EN eng BMC http://www.malariajournal.com/content/9/1/143 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-9-143 1475-2875 https://doaj.org/article/92ef410d54254d0fb1ab7933dd13c86e Malaria Journal, Vol 9, Iss 1, p 143 (2010) Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2010 ftdoajarticles https://doi.org/10.1186/1475-2875-9-143 2022-12-31T06:54:35Z Abstract Background The probability of contracting malaria in a given individual is determined not only by the individual's characteristics, but also the ecological factors that characterize the level of human-vector contact in the population. Examination of the relationship between "individual" and "supra-individual" variables over time is important for understanding the local malaria epidemiology. This is essential for planning effective intervention strategies specifically for each location. Methods A retrospective cohort study was conducted, which followed a community-cohort of about 3,500 residents in seven hamlets along the Thai-Myanmar border between 1999 and 2006. Potential malaria determinants measured at different levels (temporal variables, individual variables, and hamlet variables) were incorporated into multilevel models to estimate their effects on an individual's risk of malaria attack. Results The monthly minimum temperature was significantly associated with the seasonal variation of malaria risk. An individual risk of malaria attack decreased by about 50% during the period that active surveillance was conducted; an additional 15% and 25% reduction of Plasmodium falciparum and Plasmodium vivax incidence, respectively, was observed after the use of artesunate-mefloquine combination therapy (ACT) for treatment of P. falciparum . Male children (age < 16 years old) were at highest risk of both P. falciparum and P. vivax attack. An increase in the hamlet's incidence of P. falciparum and P. vivax by 1 per 100 persons in a previous month resulted in 1.14 and 1.34 times increase in the risk of P. falciparum and P. vivax , respectively, among individuals in a particular hamlet. Conclusion In a small area with low malaria transmission intensity, the variation in mosquito abundance is relatively similar across the residential areas; incidence of malaria between hamlets, which reflects the community level of human infectious reservoirs, is an important predictor for the malaria risk among individuals ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 9 1 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Chaimungkun Wuthichai Maneeboonyang Wanchai Thanyavanich Nipon Puangsa-art Supalap Yimsamran Surapon Chavez Irwin F Lawpoolsri Saranath Singhasivanon Pratap Maguire James H Hungerford Laura L The impact of human reservoir of malaria at a community-level on individual malaria occurrence in a low malaria transmission setting along the Thai-Myanmar border |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background The probability of contracting malaria in a given individual is determined not only by the individual's characteristics, but also the ecological factors that characterize the level of human-vector contact in the population. Examination of the relationship between "individual" and "supra-individual" variables over time is important for understanding the local malaria epidemiology. This is essential for planning effective intervention strategies specifically for each location. Methods A retrospective cohort study was conducted, which followed a community-cohort of about 3,500 residents in seven hamlets along the Thai-Myanmar border between 1999 and 2006. Potential malaria determinants measured at different levels (temporal variables, individual variables, and hamlet variables) were incorporated into multilevel models to estimate their effects on an individual's risk of malaria attack. Results The monthly minimum temperature was significantly associated with the seasonal variation of malaria risk. An individual risk of malaria attack decreased by about 50% during the period that active surveillance was conducted; an additional 15% and 25% reduction of Plasmodium falciparum and Plasmodium vivax incidence, respectively, was observed after the use of artesunate-mefloquine combination therapy (ACT) for treatment of P. falciparum . Male children (age < 16 years old) were at highest risk of both P. falciparum and P. vivax attack. An increase in the hamlet's incidence of P. falciparum and P. vivax by 1 per 100 persons in a previous month resulted in 1.14 and 1.34 times increase in the risk of P. falciparum and P. vivax , respectively, among individuals in a particular hamlet. Conclusion In a small area with low malaria transmission intensity, the variation in mosquito abundance is relatively similar across the residential areas; incidence of malaria between hamlets, which reflects the community level of human infectious reservoirs, is an important predictor for the malaria risk among individuals ... |
format |
Article in Journal/Newspaper |
author |
Chaimungkun Wuthichai Maneeboonyang Wanchai Thanyavanich Nipon Puangsa-art Supalap Yimsamran Surapon Chavez Irwin F Lawpoolsri Saranath Singhasivanon Pratap Maguire James H Hungerford Laura L |
author_facet |
Chaimungkun Wuthichai Maneeboonyang Wanchai Thanyavanich Nipon Puangsa-art Supalap Yimsamran Surapon Chavez Irwin F Lawpoolsri Saranath Singhasivanon Pratap Maguire James H Hungerford Laura L |
author_sort |
Chaimungkun Wuthichai |
title |
The impact of human reservoir of malaria at a community-level on individual malaria occurrence in a low malaria transmission setting along the Thai-Myanmar border |
title_short |
The impact of human reservoir of malaria at a community-level on individual malaria occurrence in a low malaria transmission setting along the Thai-Myanmar border |
title_full |
The impact of human reservoir of malaria at a community-level on individual malaria occurrence in a low malaria transmission setting along the Thai-Myanmar border |
title_fullStr |
The impact of human reservoir of malaria at a community-level on individual malaria occurrence in a low malaria transmission setting along the Thai-Myanmar border |
title_full_unstemmed |
The impact of human reservoir of malaria at a community-level on individual malaria occurrence in a low malaria transmission setting along the Thai-Myanmar border |
title_sort |
impact of human reservoir of malaria at a community-level on individual malaria occurrence in a low malaria transmission setting along the thai-myanmar border |
publisher |
BMC |
publishDate |
2010 |
url |
https://doi.org/10.1186/1475-2875-9-143 https://doaj.org/article/92ef410d54254d0fb1ab7933dd13c86e |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 9, Iss 1, p 143 (2010) |
op_relation |
http://www.malariajournal.com/content/9/1/143 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-9-143 1475-2875 https://doaj.org/article/92ef410d54254d0fb1ab7933dd13c86e |
op_doi |
https://doi.org/10.1186/1475-2875-9-143 |
container_title |
Malaria Journal |
container_volume |
9 |
container_issue |
1 |
_version_ |
1766345442300264448 |