Comparative analysis of two-dimensional electrophoresis maps (2-DE) of Helicobacter pylori from Brazilian patients with chronic gastritis and duodenal ulcer: a preliminary report Análise comparativa de mapas de eletroforese bidimensional (2-DE) de Helicobacter pylori de pacientes brasileiros com úlcera duodenal e gastrite crônica: relato preliminar
Helicobacter pylori is a bacterium recognized as the major cause of peptic ulcer and chronic gastritis. Recently, a proteome-based approach was developed to investigate pathogenic factors related to H. pylori. In this preliminary study, H. pylori strains were isolated from gastric biopsies of patien...
Published in: | Revista do Instituto de Medicina Tropical de São Paulo |
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ftdoajarticles:oai:doaj.org/article:92c7e3bef9044b999d7a017378dde9da 2024-09-09T19:28:02+00:00 Comparative analysis of two-dimensional electrophoresis maps (2-DE) of Helicobacter pylori from Brazilian patients with chronic gastritis and duodenal ulcer: a preliminary report Análise comparativa de mapas de eletroforese bidimensional (2-DE) de Helicobacter pylori de pacientes brasileiros com úlcera duodenal e gastrite crônica: relato preliminar Diego R.B. Pereira Daniel Martins Flavia V. Winck Marcus B. Smolka Nancy F. Nishimura Elizabeth M.A. Rabelo-Gonçalves Natalicia H. Hara Sérgio Marangoni José Murilo R. Zeitune José Camillo Novello 2006-06-01T00:00:00Z https://doi.org/10.1590/S0036-46652006000300011 https://doaj.org/article/92c7e3bef9044b999d7a017378dde9da EN eng Universidade de São Paulo (USP) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652006000300011 https://doaj.org/toc/0036-4665 https://doaj.org/toc/1678-9946 doi:10.1590/S0036-46652006000300011 0036-4665 1678-9946 https://doaj.org/article/92c7e3bef9044b999d7a017378dde9da Revista do Instituto de Medicina Tropical de São Paulo, Vol 48, Iss 3, Pp 175-177 (2006) Helicobacter pylori Proteome Bidimensional electrophoresis Chronic gastritis Peptic ulcers Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2006 ftdoajarticles https://doi.org/10.1590/S0036-46652006000300011 2024-08-05T17:49:31Z Helicobacter pylori is a bacterium recognized as the major cause of peptic ulcer and chronic gastritis. Recently, a proteome-based approach was developed to investigate pathogenic factors related to H. pylori. In this preliminary study, H. pylori strains were isolated from gastric biopsies of patients with chronic gastritis and duodenal ulcers. A partial proteomic analysis of H. pylori strains was performed by bacterial lyses and proteins were separated by two-dimensional gel electrophoresis (2-DE). A comparative analysis was performed to verify a differential protein expression between these two 2-DE maps. These data should be useful to clarify the role of different proteins related to bacterial pathogenesis. This study will be completed using a larger number of samples and protein identification of H. pylori by MALDI-TOF mass spectrometry. O Helicobacter pylori é uma bactéria reconhecida como a principal causa de úlcera péptica e gastrite crônica. Recentemente, o proteoma do H. pylori tem sido desenvolvido visando identificar fatores patogênicos relacionados ao microorganismo. Neste estudo preliminar, cepas de H. pylori foram isoladas de fragmento de mucosa gástrica de pacientes com úlcera duodenal e gastrite crônica. Posteriormente, realizou-se uma análise proteômica parcial dessas cepas, através da lise bacteriana e da separação de proteínas através da eletroforese de duas dimensões (2-DE). Por análise comparativa, foi possível verificar a expressão protéica diferencial entre os dois mapas 2-DE obtidos. Os dados poderão ser úteis para esclarecer a importância de diferentes proteínas relacionadas à patogênese da bactéria. Este estudo será complementado utilizando um maior número de amostras e a identificação protéica do H. pylori através da espectrometria de massa do tipo MALDI-TOF. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista do Instituto de Medicina Tropical de São Paulo 48 3 175 177 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Helicobacter pylori Proteome Bidimensional electrophoresis Chronic gastritis Peptic ulcers Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Helicobacter pylori Proteome Bidimensional electrophoresis Chronic gastritis Peptic ulcers Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Diego R.B. Pereira Daniel Martins Flavia V. Winck Marcus B. Smolka Nancy F. Nishimura Elizabeth M.A. Rabelo-Gonçalves Natalicia H. Hara Sérgio Marangoni José Murilo R. Zeitune José Camillo Novello Comparative analysis of two-dimensional electrophoresis maps (2-DE) of Helicobacter pylori from Brazilian patients with chronic gastritis and duodenal ulcer: a preliminary report Análise comparativa de mapas de eletroforese bidimensional (2-DE) de Helicobacter pylori de pacientes brasileiros com úlcera duodenal e gastrite crônica: relato preliminar |
topic_facet |
Helicobacter pylori Proteome Bidimensional electrophoresis Chronic gastritis Peptic ulcers Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Helicobacter pylori is a bacterium recognized as the major cause of peptic ulcer and chronic gastritis. Recently, a proteome-based approach was developed to investigate pathogenic factors related to H. pylori. In this preliminary study, H. pylori strains were isolated from gastric biopsies of patients with chronic gastritis and duodenal ulcers. A partial proteomic analysis of H. pylori strains was performed by bacterial lyses and proteins were separated by two-dimensional gel electrophoresis (2-DE). A comparative analysis was performed to verify a differential protein expression between these two 2-DE maps. These data should be useful to clarify the role of different proteins related to bacterial pathogenesis. This study will be completed using a larger number of samples and protein identification of H. pylori by MALDI-TOF mass spectrometry. O Helicobacter pylori é uma bactéria reconhecida como a principal causa de úlcera péptica e gastrite crônica. Recentemente, o proteoma do H. pylori tem sido desenvolvido visando identificar fatores patogênicos relacionados ao microorganismo. Neste estudo preliminar, cepas de H. pylori foram isoladas de fragmento de mucosa gástrica de pacientes com úlcera duodenal e gastrite crônica. Posteriormente, realizou-se uma análise proteômica parcial dessas cepas, através da lise bacteriana e da separação de proteínas através da eletroforese de duas dimensões (2-DE). Por análise comparativa, foi possível verificar a expressão protéica diferencial entre os dois mapas 2-DE obtidos. Os dados poderão ser úteis para esclarecer a importância de diferentes proteínas relacionadas à patogênese da bactéria. Este estudo será complementado utilizando um maior número de amostras e a identificação protéica do H. pylori através da espectrometria de massa do tipo MALDI-TOF. |
format |
Article in Journal/Newspaper |
author |
Diego R.B. Pereira Daniel Martins Flavia V. Winck Marcus B. Smolka Nancy F. Nishimura Elizabeth M.A. Rabelo-Gonçalves Natalicia H. Hara Sérgio Marangoni José Murilo R. Zeitune José Camillo Novello |
author_facet |
Diego R.B. Pereira Daniel Martins Flavia V. Winck Marcus B. Smolka Nancy F. Nishimura Elizabeth M.A. Rabelo-Gonçalves Natalicia H. Hara Sérgio Marangoni José Murilo R. Zeitune José Camillo Novello |
author_sort |
Diego R.B. Pereira |
title |
Comparative analysis of two-dimensional electrophoresis maps (2-DE) of Helicobacter pylori from Brazilian patients with chronic gastritis and duodenal ulcer: a preliminary report Análise comparativa de mapas de eletroforese bidimensional (2-DE) de Helicobacter pylori de pacientes brasileiros com úlcera duodenal e gastrite crônica: relato preliminar |
title_short |
Comparative analysis of two-dimensional electrophoresis maps (2-DE) of Helicobacter pylori from Brazilian patients with chronic gastritis and duodenal ulcer: a preliminary report Análise comparativa de mapas de eletroforese bidimensional (2-DE) de Helicobacter pylori de pacientes brasileiros com úlcera duodenal e gastrite crônica: relato preliminar |
title_full |
Comparative analysis of two-dimensional electrophoresis maps (2-DE) of Helicobacter pylori from Brazilian patients with chronic gastritis and duodenal ulcer: a preliminary report Análise comparativa de mapas de eletroforese bidimensional (2-DE) de Helicobacter pylori de pacientes brasileiros com úlcera duodenal e gastrite crônica: relato preliminar |
title_fullStr |
Comparative analysis of two-dimensional electrophoresis maps (2-DE) of Helicobacter pylori from Brazilian patients with chronic gastritis and duodenal ulcer: a preliminary report Análise comparativa de mapas de eletroforese bidimensional (2-DE) de Helicobacter pylori de pacientes brasileiros com úlcera duodenal e gastrite crônica: relato preliminar |
title_full_unstemmed |
Comparative analysis of two-dimensional electrophoresis maps (2-DE) of Helicobacter pylori from Brazilian patients with chronic gastritis and duodenal ulcer: a preliminary report Análise comparativa de mapas de eletroforese bidimensional (2-DE) de Helicobacter pylori de pacientes brasileiros com úlcera duodenal e gastrite crônica: relato preliminar |
title_sort |
comparative analysis of two-dimensional electrophoresis maps (2-de) of helicobacter pylori from brazilian patients with chronic gastritis and duodenal ulcer: a preliminary report análise comparativa de mapas de eletroforese bidimensional (2-de) de helicobacter pylori de pacientes brasileiros com úlcera duodenal e gastrite crônica: relato preliminar |
publisher |
Universidade de São Paulo (USP) |
publishDate |
2006 |
url |
https://doi.org/10.1590/S0036-46652006000300011 https://doaj.org/article/92c7e3bef9044b999d7a017378dde9da |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista do Instituto de Medicina Tropical de São Paulo, Vol 48, Iss 3, Pp 175-177 (2006) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652006000300011 https://doaj.org/toc/0036-4665 https://doaj.org/toc/1678-9946 doi:10.1590/S0036-46652006000300011 0036-4665 1678-9946 https://doaj.org/article/92c7e3bef9044b999d7a017378dde9da |
op_doi |
https://doi.org/10.1590/S0036-46652006000300011 |
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