The protective role of daidzein in intestinal health of turbot (Scophthalmus maximus L.) fed soybean meal-based diets
Abstract Soybean meal-induced enteropathy (SBMIE) is prevalent in aquaculture. The aim of this study is to evaluate the role of daidzein on SBMIE of juvenile turbot (Scophthalmus maximus L.) by feeding with fish meal diet (FM), soybean meal diet (SBM, 40% fish meal protein in FM replaced by soybean...
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ftdoajarticles:oai:doaj.org/article:92a88b09cf704603b98e1a4a52026a80 2023-05-15T18:15:44+02:00 The protective role of daidzein in intestinal health of turbot (Scophthalmus maximus L.) fed soybean meal-based diets Guijuan Yu Yang Liu Weihao Ou Jihong Dai Qinghui Ai Wenbing Zhang Kangsen Mai Yanjiao Zhang 2021-02-01T00:00:00Z https://doi.org/10.1038/s41598-021-82866-1 https://doaj.org/article/92a88b09cf704603b98e1a4a52026a80 EN eng Nature Portfolio https://doi.org/10.1038/s41598-021-82866-1 https://doaj.org/toc/2045-2322 doi:10.1038/s41598-021-82866-1 2045-2322 https://doaj.org/article/92a88b09cf704603b98e1a4a52026a80 Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021) Medicine R Science Q article 2021 ftdoajarticles https://doi.org/10.1038/s41598-021-82866-1 2022-12-31T07:32:52Z Abstract Soybean meal-induced enteropathy (SBMIE) is prevalent in aquaculture. The aim of this study is to evaluate the role of daidzein on SBMIE of juvenile turbot (Scophthalmus maximus L.) by feeding with fish meal diet (FM), soybean meal diet (SBM, 40% fish meal protein in FM replaced by soybean meal protein) and daidzein diet (DAID, 40 mg/kg daidzein supplemented to SBM) for 12 weeks. We found that daidzein supplementation elevated the gene expression of anti-inflammatory cytokine TGF-β, decreased gene expression of pro-inflammatory cytokines TNF-α and signal molecules p38, JNK and NF-κB. SBM up-regulated the genes expression related to oxidative stress and apoptosis, but dietary daidzein restored it to the similar level with that in FM group. Moreover, dietary daidzein up-regulated gene expression of tight junction protein, and modified the intestinal microbial profiles with boosted relative abundance of phylum Proteobacteria and Deinococcus–Thermus, genera Sphingomonas and Thermus, species Lactococcus lactis, and decreased abundance of some potential pathogenic bacteria. In conclusion, dietary daidzein could ameliorate SBM-induced intestinal inflammatory response, oxidative stress, mucosal barrier injury and microbiota community disorder of turbot. Moreover, p38, JNK and NF-κB signaling might be involved in the anti-inflammatory process of daidzein, and daidzein itself might act as an antioxidant to resist SBM-induced oxidative damage. Article in Journal/Newspaper Scophthalmus maximus Turbot Directory of Open Access Journals: DOAJ Articles Scientific Reports 11 1 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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Medicine R Science Q |
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Medicine R Science Q Guijuan Yu Yang Liu Weihao Ou Jihong Dai Qinghui Ai Wenbing Zhang Kangsen Mai Yanjiao Zhang The protective role of daidzein in intestinal health of turbot (Scophthalmus maximus L.) fed soybean meal-based diets |
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Medicine R Science Q |
description |
Abstract Soybean meal-induced enteropathy (SBMIE) is prevalent in aquaculture. The aim of this study is to evaluate the role of daidzein on SBMIE of juvenile turbot (Scophthalmus maximus L.) by feeding with fish meal diet (FM), soybean meal diet (SBM, 40% fish meal protein in FM replaced by soybean meal protein) and daidzein diet (DAID, 40 mg/kg daidzein supplemented to SBM) for 12 weeks. We found that daidzein supplementation elevated the gene expression of anti-inflammatory cytokine TGF-β, decreased gene expression of pro-inflammatory cytokines TNF-α and signal molecules p38, JNK and NF-κB. SBM up-regulated the genes expression related to oxidative stress and apoptosis, but dietary daidzein restored it to the similar level with that in FM group. Moreover, dietary daidzein up-regulated gene expression of tight junction protein, and modified the intestinal microbial profiles with boosted relative abundance of phylum Proteobacteria and Deinococcus–Thermus, genera Sphingomonas and Thermus, species Lactococcus lactis, and decreased abundance of some potential pathogenic bacteria. In conclusion, dietary daidzein could ameliorate SBM-induced intestinal inflammatory response, oxidative stress, mucosal barrier injury and microbiota community disorder of turbot. Moreover, p38, JNK and NF-κB signaling might be involved in the anti-inflammatory process of daidzein, and daidzein itself might act as an antioxidant to resist SBM-induced oxidative damage. |
format |
Article in Journal/Newspaper |
author |
Guijuan Yu Yang Liu Weihao Ou Jihong Dai Qinghui Ai Wenbing Zhang Kangsen Mai Yanjiao Zhang |
author_facet |
Guijuan Yu Yang Liu Weihao Ou Jihong Dai Qinghui Ai Wenbing Zhang Kangsen Mai Yanjiao Zhang |
author_sort |
Guijuan Yu |
title |
The protective role of daidzein in intestinal health of turbot (Scophthalmus maximus L.) fed soybean meal-based diets |
title_short |
The protective role of daidzein in intestinal health of turbot (Scophthalmus maximus L.) fed soybean meal-based diets |
title_full |
The protective role of daidzein in intestinal health of turbot (Scophthalmus maximus L.) fed soybean meal-based diets |
title_fullStr |
The protective role of daidzein in intestinal health of turbot (Scophthalmus maximus L.) fed soybean meal-based diets |
title_full_unstemmed |
The protective role of daidzein in intestinal health of turbot (Scophthalmus maximus L.) fed soybean meal-based diets |
title_sort |
protective role of daidzein in intestinal health of turbot (scophthalmus maximus l.) fed soybean meal-based diets |
publisher |
Nature Portfolio |
publishDate |
2021 |
url |
https://doi.org/10.1038/s41598-021-82866-1 https://doaj.org/article/92a88b09cf704603b98e1a4a52026a80 |
genre |
Scophthalmus maximus Turbot |
genre_facet |
Scophthalmus maximus Turbot |
op_source |
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021) |
op_relation |
https://doi.org/10.1038/s41598-021-82866-1 https://doaj.org/toc/2045-2322 doi:10.1038/s41598-021-82866-1 2045-2322 https://doaj.org/article/92a88b09cf704603b98e1a4a52026a80 |
op_doi |
https://doi.org/10.1038/s41598-021-82866-1 |
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Scientific Reports |
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11 |
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