CATASAN Is a New Anti-Biofilm Agent Produced by the Marine Antarctic Bacterium Psychrobacter sp. TAE2020
The development of new approaches to prevent microbial surface adhesion and biofilm formation is an emerging need following the growing understanding of the impact of biofilm-related infections on human health. Staphylococcus epidermidis , with its ability to form biofilm and colonize biomaterials,...
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ftdoajarticles:oai:doaj.org/article:92669e86eb004fb0a3291f6a8e084a44 2023-05-15T13:44:38+02:00 CATASAN Is a New Anti-Biofilm Agent Produced by the Marine Antarctic Bacterium Psychrobacter sp. TAE2020 Caterina D’Angelo Angela Casillo Chiara Melchiorre Concetta Lauro Maria Michela Corsaro Andrea Carpentieri Maria Luisa Tutino Ermenegilda Parrilli 2022-11-01T00:00:00Z https://doi.org/10.3390/md20120747 https://doaj.org/article/92669e86eb004fb0a3291f6a8e084a44 EN eng MDPI AG https://www.mdpi.com/1660-3397/20/12/747 https://doaj.org/toc/1660-3397 doi:10.3390/md20120747 1660-3397 https://doaj.org/article/92669e86eb004fb0a3291f6a8e084a44 Marine Drugs, Vol 20, Iss 747, p 747 (2022) anti-biofilm anti-adhesive bioemulsifier biosurfactant Psychrobacter sp. TAE2020 Biology (General) QH301-705.5 article 2022 ftdoajarticles https://doi.org/10.3390/md20120747 2022-12-30T19:31:11Z The development of new approaches to prevent microbial surface adhesion and biofilm formation is an emerging need following the growing understanding of the impact of biofilm-related infections on human health. Staphylococcus epidermidis , with its ability to form biofilm and colonize biomaterials, represents the most frequent causative agent involved in infections of medical devices. In the research of new anti-biofilm agents against S. epidermidis biofilm, Antarctic marine bacteria represent an untapped reservoir of biodiversity. In the present study, the attention was focused on Psychrobacter sp . TAE2020, an Antarctic marine bacterium that produces molecules able to impair the initial attachment of S. epidermidis strains to the polystyrene surface. The setup of suitable purification protocols allowed the identification by NMR spectroscopy and LC-MS/MS analysis of a protein–polysaccharide complex named CATASAN. This complex proved to be a very effective anti-biofilm agent. Indeed, it not only interferes with cell surface attachment, but also prevents biofilm formation and affects the mature biofilm matrix structure of S. epidermidis . Moreover, CATASAN is endowed with a good emulsification activity in a wide range of pH and temperature. Therefore, its use can be easily extended to different biotechnological applications. Article in Journal/Newspaper Antarc* Antarctic Directory of Open Access Journals: DOAJ Articles Antarctic Marine Drugs 20 12 747 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
anti-biofilm anti-adhesive bioemulsifier biosurfactant Psychrobacter sp. TAE2020 Biology (General) QH301-705.5 |
spellingShingle |
anti-biofilm anti-adhesive bioemulsifier biosurfactant Psychrobacter sp. TAE2020 Biology (General) QH301-705.5 Caterina D’Angelo Angela Casillo Chiara Melchiorre Concetta Lauro Maria Michela Corsaro Andrea Carpentieri Maria Luisa Tutino Ermenegilda Parrilli CATASAN Is a New Anti-Biofilm Agent Produced by the Marine Antarctic Bacterium Psychrobacter sp. TAE2020 |
topic_facet |
anti-biofilm anti-adhesive bioemulsifier biosurfactant Psychrobacter sp. TAE2020 Biology (General) QH301-705.5 |
description |
The development of new approaches to prevent microbial surface adhesion and biofilm formation is an emerging need following the growing understanding of the impact of biofilm-related infections on human health. Staphylococcus epidermidis , with its ability to form biofilm and colonize biomaterials, represents the most frequent causative agent involved in infections of medical devices. In the research of new anti-biofilm agents against S. epidermidis biofilm, Antarctic marine bacteria represent an untapped reservoir of biodiversity. In the present study, the attention was focused on Psychrobacter sp . TAE2020, an Antarctic marine bacterium that produces molecules able to impair the initial attachment of S. epidermidis strains to the polystyrene surface. The setup of suitable purification protocols allowed the identification by NMR spectroscopy and LC-MS/MS analysis of a protein–polysaccharide complex named CATASAN. This complex proved to be a very effective anti-biofilm agent. Indeed, it not only interferes with cell surface attachment, but also prevents biofilm formation and affects the mature biofilm matrix structure of S. epidermidis . Moreover, CATASAN is endowed with a good emulsification activity in a wide range of pH and temperature. Therefore, its use can be easily extended to different biotechnological applications. |
format |
Article in Journal/Newspaper |
author |
Caterina D’Angelo Angela Casillo Chiara Melchiorre Concetta Lauro Maria Michela Corsaro Andrea Carpentieri Maria Luisa Tutino Ermenegilda Parrilli |
author_facet |
Caterina D’Angelo Angela Casillo Chiara Melchiorre Concetta Lauro Maria Michela Corsaro Andrea Carpentieri Maria Luisa Tutino Ermenegilda Parrilli |
author_sort |
Caterina D’Angelo |
title |
CATASAN Is a New Anti-Biofilm Agent Produced by the Marine Antarctic Bacterium Psychrobacter sp. TAE2020 |
title_short |
CATASAN Is a New Anti-Biofilm Agent Produced by the Marine Antarctic Bacterium Psychrobacter sp. TAE2020 |
title_full |
CATASAN Is a New Anti-Biofilm Agent Produced by the Marine Antarctic Bacterium Psychrobacter sp. TAE2020 |
title_fullStr |
CATASAN Is a New Anti-Biofilm Agent Produced by the Marine Antarctic Bacterium Psychrobacter sp. TAE2020 |
title_full_unstemmed |
CATASAN Is a New Anti-Biofilm Agent Produced by the Marine Antarctic Bacterium Psychrobacter sp. TAE2020 |
title_sort |
catasan is a new anti-biofilm agent produced by the marine antarctic bacterium psychrobacter sp. tae2020 |
publisher |
MDPI AG |
publishDate |
2022 |
url |
https://doi.org/10.3390/md20120747 https://doaj.org/article/92669e86eb004fb0a3291f6a8e084a44 |
geographic |
Antarctic |
geographic_facet |
Antarctic |
genre |
Antarc* Antarctic |
genre_facet |
Antarc* Antarctic |
op_source |
Marine Drugs, Vol 20, Iss 747, p 747 (2022) |
op_relation |
https://www.mdpi.com/1660-3397/20/12/747 https://doaj.org/toc/1660-3397 doi:10.3390/md20120747 1660-3397 https://doaj.org/article/92669e86eb004fb0a3291f6a8e084a44 |
op_doi |
https://doi.org/10.3390/md20120747 |
container_title |
Marine Drugs |
container_volume |
20 |
container_issue |
12 |
container_start_page |
747 |
_version_ |
1766204205078413312 |