Bovine tuberculosis in African buffalo (Syncerus caffer): Progression of pathology during infection.
Background Bovine tuberculosis (BTB) is a zoonotic disease of global importance endemic in African buffalo (Syncerus caffer) in sub-Saharan Africa. Zoonotic tuberculosis is a disease of global importance, accounting for over 12,000 deaths annually. Cattle affected with BTB have been proposed as a mo...
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ftdoajarticles:oai:doaj.org/article:923995b0e9c149ab8d7b581eaec1f2ab 2023-05-15T15:14:21+02:00 Bovine tuberculosis in African buffalo (Syncerus caffer): Progression of pathology during infection. Hilary Ann Lakin Hannah Tavalire Kaori Sakamoto Peter Buss Michele Miller Sarah A Budischak Kristina Raum Vanessa O Ezenwa Brianna Beechler Anna Jolles 2022-11-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0010906 https://doaj.org/article/923995b0e9c149ab8d7b581eaec1f2ab EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0010906 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0010906 https://doaj.org/article/923995b0e9c149ab8d7b581eaec1f2ab PLoS Neglected Tropical Diseases, Vol 16, Iss 11, p e0010906 (2022) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2022 ftdoajarticles https://doi.org/10.1371/journal.pntd.0010906 2022-12-30T22:31:50Z Background Bovine tuberculosis (BTB) is a zoonotic disease of global importance endemic in African buffalo (Syncerus caffer) in sub-Saharan Africa. Zoonotic tuberculosis is a disease of global importance, accounting for over 12,000 deaths annually. Cattle affected with BTB have been proposed as a model for the study of human tuberculosis, more closely resembling the localization and progression of lesions in controlled studies than murine models. If disease in African buffalo progresses similarly to experimentally infected cattle, they may serve as a model, both for human tuberculosis and cattle BTB, in a natural environment. Methodology/principal findings We utilized a herd of African buffalo that were captured, fitted with radio collars, and tested for BTB twice annually during a 4-year-cohort study. At the end of the project, BTB positive buffalo were culled, and necropsies performed. Here we describe the pathologic progression of BTB over time in African buffalo, utilizing gross and histological methods. We found that BTB in buffalo follows a pattern of infection like that seen in experimental studies of cattle. BTB localizes to the lymph nodes of the respiratory tract first, beginning with the retropharyngeal and tracheobronchial lymph nodes, gradually increasing in lymph nodes affected over time. At 36 months, rate of spread to additional lymph nodes sharply increases. The lung lesions follow a similar pattern, progressing slowly, then accelerating their progression at 36 months post infection. Lastly, a genetic marker that correlated to risk of M. bovis infection in previous studies was marginally associated with BTB progression. Buffalo with at least one risk allele at this locus tended to progress faster, with more lung necrosis. Conclusions/significance The progression of disease in the African buffalo mirrors the progression found in experimental cattle models, offering insight into BTB and the interaction with its host in the context of naturally varying environments, host, and pathogen populations. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 16 11 e0010906 |
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Directory of Open Access Journals: DOAJ Articles |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Hilary Ann Lakin Hannah Tavalire Kaori Sakamoto Peter Buss Michele Miller Sarah A Budischak Kristina Raum Vanessa O Ezenwa Brianna Beechler Anna Jolles Bovine tuberculosis in African buffalo (Syncerus caffer): Progression of pathology during infection. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Background Bovine tuberculosis (BTB) is a zoonotic disease of global importance endemic in African buffalo (Syncerus caffer) in sub-Saharan Africa. Zoonotic tuberculosis is a disease of global importance, accounting for over 12,000 deaths annually. Cattle affected with BTB have been proposed as a model for the study of human tuberculosis, more closely resembling the localization and progression of lesions in controlled studies than murine models. If disease in African buffalo progresses similarly to experimentally infected cattle, they may serve as a model, both for human tuberculosis and cattle BTB, in a natural environment. Methodology/principal findings We utilized a herd of African buffalo that were captured, fitted with radio collars, and tested for BTB twice annually during a 4-year-cohort study. At the end of the project, BTB positive buffalo were culled, and necropsies performed. Here we describe the pathologic progression of BTB over time in African buffalo, utilizing gross and histological methods. We found that BTB in buffalo follows a pattern of infection like that seen in experimental studies of cattle. BTB localizes to the lymph nodes of the respiratory tract first, beginning with the retropharyngeal and tracheobronchial lymph nodes, gradually increasing in lymph nodes affected over time. At 36 months, rate of spread to additional lymph nodes sharply increases. The lung lesions follow a similar pattern, progressing slowly, then accelerating their progression at 36 months post infection. Lastly, a genetic marker that correlated to risk of M. bovis infection in previous studies was marginally associated with BTB progression. Buffalo with at least one risk allele at this locus tended to progress faster, with more lung necrosis. Conclusions/significance The progression of disease in the African buffalo mirrors the progression found in experimental cattle models, offering insight into BTB and the interaction with its host in the context of naturally varying environments, host, and pathogen populations. |
format |
Article in Journal/Newspaper |
author |
Hilary Ann Lakin Hannah Tavalire Kaori Sakamoto Peter Buss Michele Miller Sarah A Budischak Kristina Raum Vanessa O Ezenwa Brianna Beechler Anna Jolles |
author_facet |
Hilary Ann Lakin Hannah Tavalire Kaori Sakamoto Peter Buss Michele Miller Sarah A Budischak Kristina Raum Vanessa O Ezenwa Brianna Beechler Anna Jolles |
author_sort |
Hilary Ann Lakin |
title |
Bovine tuberculosis in African buffalo (Syncerus caffer): Progression of pathology during infection. |
title_short |
Bovine tuberculosis in African buffalo (Syncerus caffer): Progression of pathology during infection. |
title_full |
Bovine tuberculosis in African buffalo (Syncerus caffer): Progression of pathology during infection. |
title_fullStr |
Bovine tuberculosis in African buffalo (Syncerus caffer): Progression of pathology during infection. |
title_full_unstemmed |
Bovine tuberculosis in African buffalo (Syncerus caffer): Progression of pathology during infection. |
title_sort |
bovine tuberculosis in african buffalo (syncerus caffer): progression of pathology during infection. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2022 |
url |
https://doi.org/10.1371/journal.pntd.0010906 https://doaj.org/article/923995b0e9c149ab8d7b581eaec1f2ab |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 16, Iss 11, p e0010906 (2022) |
op_relation |
https://doi.org/10.1371/journal.pntd.0010906 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0010906 https://doaj.org/article/923995b0e9c149ab8d7b581eaec1f2ab |
op_doi |
https://doi.org/10.1371/journal.pntd.0010906 |
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PLOS Neglected Tropical Diseases |
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16 |
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11 |
container_start_page |
e0010906 |
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