Abnormal spontaneous interleukin 8 receptor expression: a brief report of two cases
Interleukin 8 (CXCL8) is an autocrine chemokine specific for the chemoattraction and activation of granulocytes, NKT cells and T lymphocytes. Patients with tuberculosis and latent Mycobacterium tuberculosis infection were assessed for the spontaneous expression of CXCR1 (CD128) and CXCR2 on lymphocy...
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Sociedade Brasileira de Medicina Tropical (SBMT)
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ftdoajarticles:oai:doaj.org/article:922fd3cf559e465da9f8a8fd914e84b0 2023-05-15T15:01:39+02:00 Abnormal spontaneous interleukin 8 receptor expression: a brief report of two cases Paulo Antas Steven Holland Timothy Sterling 2012-02-01T00:00:00Z https://doi.org/10.1590/S0037-86822012000100029 https://doaj.org/article/922fd3cf559e465da9f8a8fd914e84b0 EN eng Sociedade Brasileira de Medicina Tropical (SBMT) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822012000100029&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/S0037-86822012000100029 https://doaj.org/article/922fd3cf559e465da9f8a8fd914e84b0 Revista da Sociedade Brasileira de Medicina Tropical, Vol 45, Iss 1, Pp 134-137 (2012) Receptor de interleucina 8 Linfócitos Citocinas Arctic medicine. Tropical medicine RC955-962 article 2012 ftdoajarticles https://doi.org/10.1590/S0037-86822012000100029 2022-12-30T23:18:03Z Interleukin 8 (CXCL8) is an autocrine chemokine specific for the chemoattraction and activation of granulocytes, NKT cells and T lymphocytes. Patients with tuberculosis and latent Mycobacterium tuberculosis infection were assessed for the spontaneous expression of CXCR1 (CD128) and CXCR2 on lymphocytes and monocytes. Compared with ex vivo profiles, increased spontaneous CXCR2 expression and normal CXCR1 expression were found on lymphocytes in two out of 59 individuals. Monocytes showed normal ex vivo profiles for both receptors. After stimulation with purified protein derivative, the in vitro levels of CXCL8 were below the median levels of all patients with prior tuberculosis. Spontaneous CXCR2 modulation did not cause notable variation in the in vitro levels of CXCL8. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista da Sociedade Brasileira de Medicina Tropical 45 1 134 137 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Receptor de interleucina 8 Linfócitos Citocinas Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Receptor de interleucina 8 Linfócitos Citocinas Arctic medicine. Tropical medicine RC955-962 Paulo Antas Steven Holland Timothy Sterling Abnormal spontaneous interleukin 8 receptor expression: a brief report of two cases |
topic_facet |
Receptor de interleucina 8 Linfócitos Citocinas Arctic medicine. Tropical medicine RC955-962 |
description |
Interleukin 8 (CXCL8) is an autocrine chemokine specific for the chemoattraction and activation of granulocytes, NKT cells and T lymphocytes. Patients with tuberculosis and latent Mycobacterium tuberculosis infection were assessed for the spontaneous expression of CXCR1 (CD128) and CXCR2 on lymphocytes and monocytes. Compared with ex vivo profiles, increased spontaneous CXCR2 expression and normal CXCR1 expression were found on lymphocytes in two out of 59 individuals. Monocytes showed normal ex vivo profiles for both receptors. After stimulation with purified protein derivative, the in vitro levels of CXCL8 were below the median levels of all patients with prior tuberculosis. Spontaneous CXCR2 modulation did not cause notable variation in the in vitro levels of CXCL8. |
format |
Article in Journal/Newspaper |
author |
Paulo Antas Steven Holland Timothy Sterling |
author_facet |
Paulo Antas Steven Holland Timothy Sterling |
author_sort |
Paulo Antas |
title |
Abnormal spontaneous interleukin 8 receptor expression: a brief report of two cases |
title_short |
Abnormal spontaneous interleukin 8 receptor expression: a brief report of two cases |
title_full |
Abnormal spontaneous interleukin 8 receptor expression: a brief report of two cases |
title_fullStr |
Abnormal spontaneous interleukin 8 receptor expression: a brief report of two cases |
title_full_unstemmed |
Abnormal spontaneous interleukin 8 receptor expression: a brief report of two cases |
title_sort |
abnormal spontaneous interleukin 8 receptor expression: a brief report of two cases |
publisher |
Sociedade Brasileira de Medicina Tropical (SBMT) |
publishDate |
2012 |
url |
https://doi.org/10.1590/S0037-86822012000100029 https://doaj.org/article/922fd3cf559e465da9f8a8fd914e84b0 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista da Sociedade Brasileira de Medicina Tropical, Vol 45, Iss 1, Pp 134-137 (2012) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822012000100029&lng=en&tlng=en https://doaj.org/toc/1678-9849 1678-9849 doi:10.1590/S0037-86822012000100029 https://doaj.org/article/922fd3cf559e465da9f8a8fd914e84b0 |
op_doi |
https://doi.org/10.1590/S0037-86822012000100029 |
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Revista da Sociedade Brasileira de Medicina Tropical |
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45 |
container_issue |
1 |
container_start_page |
134 |
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137 |
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1766333651878936576 |